The Burden of Type 2 Diabetes in Adolescents and Young Adults in China: A Secondary Analysis from the Global Burden of Disease Study 2021
Background: Early-onset type 2 diabetes (T2D) is an increasingly serious public health issue, particularly in China. This study aimed to analyze the characteristics of disease burden, secular trend, and attributable risk factors of early-onset T2D in China. Methods: Using data from the Global Burden...
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American Association for the Advancement of Science (AAAS)
2024-01-01
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| Series: | Health Data Science |
| Online Access: | https://spj.science.org/doi/10.34133/hds.0210 |
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| author | Junting Yang Siwei Deng Houyu Zhao Feng Sun Xiantong Zou Linong Ji Siyan Zhan |
| author_facet | Junting Yang Siwei Deng Houyu Zhao Feng Sun Xiantong Zou Linong Ji Siyan Zhan |
| author_sort | Junting Yang |
| collection | DOAJ |
| description | Background: Early-onset type 2 diabetes (T2D) is an increasingly serious public health issue, particularly in China. This study aimed to analyze the characteristics of disease burden, secular trend, and attributable risk factors of early-onset T2D in China. Methods: Using data from the Global Burden of Disease (GBD) 2021, we analyzed the age-standardized rate (ASR) of incidence, disability-adjusted life years (DALYs), and mortality rates of T2D among individuals aged 15 to 39 years in China from 1990 to 2021. Joinpoint regression analysis was employed to analyze secular trend, calculating the average annual percent change (AAPC). We also examined changes in the proportion of early-onset T2D within the total T2D burden and its attributable risk factors. Results: From 1990 to 2021, the ASR of incidence of early-onset T2D in China increased from 140.20 [95% uncertainty interval (UI): 89.14 to 204.74] to 315.97 (95% UI: 226.75 to 417.55) per 100,000, with an AAPC of 2.67% (95% CI: 2.60% to 2.75%, P < 0.001). DALYs rose from 116.29 (95% UI: 78.51 to 167.05) to 267.47 (95% UI: 171.08 to 387.38) per 100,000, with an AAPC of 2.75% (95% CI: 2.64% to 2.87%, P < 0.001). Mortality rates slightly decreased from 0.30 (95% UI: 0.24 to 0.38) to 0.28 (95% UI: 0.23 to 0.34) per 100,000, with an AAPC of −0.22% (95% CI: −0.33% to −0.11%, P < 0.001). The 15 to 19 years age group showed the fastest increase in incidence (AAPC: 4.08%, 95% CI: 3.93% to 4.29%, P < 0.001). The burden was consistently higher and increased more rapidly among males compared to females. The proportion of early-onset T2D within the total T2D burden fluctuated but remained higher than global levels. In 2021, high body mass index (BMI) was the primary attributable risk factor for DALYs of early-onset T2D (59.85%, 95% UI: 33.54% to 76.65%), and its contribution increased substantially from 40.08% (95% UI: 20.71% to 55.79%) in 1990, followed by ambient particulate matter pollution (14.77%, 95% UI: 8.24% to 21.24%) and diet high in red meat (9.33%, 95% UI: −1.42% to 20.06%). Conclusion: The disease burden of early-onset T2D in China is rapidly increasing, particularly among younger populations and males. Despite a slight decrease in mortality rates, the continued rapid increase in incidence and DALYs indicates a need for strengthened prevention and management strategies, especially interventions targeting younger age groups. High BMI and environmental pollution emerge as primary risk factors and should be prioritized in future interventions. |
| format | Article |
| id | doaj-art-5bf1259366d64ddc97c0f5f0e89a2809 |
| institution | Kabale University |
| issn | 2765-8783 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | American Association for the Advancement of Science (AAAS) |
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| series | Health Data Science |
| spelling | doaj-art-5bf1259366d64ddc97c0f5f0e89a28092025-01-14T20:35:41ZengAmerican Association for the Advancement of Science (AAAS)Health Data Science2765-87832024-01-01410.34133/hds.0210The Burden of Type 2 Diabetes in Adolescents and Young Adults in China: A Secondary Analysis from the Global Burden of Disease Study 2021Junting Yang0Siwei Deng1Houyu Zhao2Feng Sun3Xiantong Zou4Linong Ji5Siyan Zhan6Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.School of Medicine, Chongqing University, Chongqing 400030, China.Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.The Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing 100044, China.The Department of Endocrinology and Metabolism, Peking University People’s Hospital, Beijing 100044, China.Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China.Background: Early-onset type 2 diabetes (T2D) is an increasingly serious public health issue, particularly in China. This study aimed to analyze the characteristics of disease burden, secular trend, and attributable risk factors of early-onset T2D in China. Methods: Using data from the Global Burden of Disease (GBD) 2021, we analyzed the age-standardized rate (ASR) of incidence, disability-adjusted life years (DALYs), and mortality rates of T2D among individuals aged 15 to 39 years in China from 1990 to 2021. Joinpoint regression analysis was employed to analyze secular trend, calculating the average annual percent change (AAPC). We also examined changes in the proportion of early-onset T2D within the total T2D burden and its attributable risk factors. Results: From 1990 to 2021, the ASR of incidence of early-onset T2D in China increased from 140.20 [95% uncertainty interval (UI): 89.14 to 204.74] to 315.97 (95% UI: 226.75 to 417.55) per 100,000, with an AAPC of 2.67% (95% CI: 2.60% to 2.75%, P < 0.001). DALYs rose from 116.29 (95% UI: 78.51 to 167.05) to 267.47 (95% UI: 171.08 to 387.38) per 100,000, with an AAPC of 2.75% (95% CI: 2.64% to 2.87%, P < 0.001). Mortality rates slightly decreased from 0.30 (95% UI: 0.24 to 0.38) to 0.28 (95% UI: 0.23 to 0.34) per 100,000, with an AAPC of −0.22% (95% CI: −0.33% to −0.11%, P < 0.001). The 15 to 19 years age group showed the fastest increase in incidence (AAPC: 4.08%, 95% CI: 3.93% to 4.29%, P < 0.001). The burden was consistently higher and increased more rapidly among males compared to females. The proportion of early-onset T2D within the total T2D burden fluctuated but remained higher than global levels. In 2021, high body mass index (BMI) was the primary attributable risk factor for DALYs of early-onset T2D (59.85%, 95% UI: 33.54% to 76.65%), and its contribution increased substantially from 40.08% (95% UI: 20.71% to 55.79%) in 1990, followed by ambient particulate matter pollution (14.77%, 95% UI: 8.24% to 21.24%) and diet high in red meat (9.33%, 95% UI: −1.42% to 20.06%). Conclusion: The disease burden of early-onset T2D in China is rapidly increasing, particularly among younger populations and males. Despite a slight decrease in mortality rates, the continued rapid increase in incidence and DALYs indicates a need for strengthened prevention and management strategies, especially interventions targeting younger age groups. High BMI and environmental pollution emerge as primary risk factors and should be prioritized in future interventions.https://spj.science.org/doi/10.34133/hds.0210 |
| spellingShingle | Junting Yang Siwei Deng Houyu Zhao Feng Sun Xiantong Zou Linong Ji Siyan Zhan The Burden of Type 2 Diabetes in Adolescents and Young Adults in China: A Secondary Analysis from the Global Burden of Disease Study 2021 Health Data Science |
| title | The Burden of Type 2 Diabetes in Adolescents and Young Adults in China: A Secondary Analysis from the Global Burden of Disease Study 2021 |
| title_full | The Burden of Type 2 Diabetes in Adolescents and Young Adults in China: A Secondary Analysis from the Global Burden of Disease Study 2021 |
| title_fullStr | The Burden of Type 2 Diabetes in Adolescents and Young Adults in China: A Secondary Analysis from the Global Burden of Disease Study 2021 |
| title_full_unstemmed | The Burden of Type 2 Diabetes in Adolescents and Young Adults in China: A Secondary Analysis from the Global Burden of Disease Study 2021 |
| title_short | The Burden of Type 2 Diabetes in Adolescents and Young Adults in China: A Secondary Analysis from the Global Burden of Disease Study 2021 |
| title_sort | burden of type 2 diabetes in adolescents and young adults in china a secondary analysis from the global burden of disease study 2021 |
| url | https://spj.science.org/doi/10.34133/hds.0210 |
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