Exploring the handedness-breast cancer nexus: a comprehensive analysis via systematic review, meta-analysis, and Mendelian randomization
Background: Given the widespread prevalence of breast cancer as a global malignancy, there is a compelling need to delve into its risk determinants. Objective: This study aims to investigate the potential relationship between indicators of left-handedness and breast cancer, employing systematic revi...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2024-12-01
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| Series: | Therapeutic Advances in Medical Oncology |
| Online Access: | https://doi.org/10.1177/17588359241305096 |
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| _version_ | 1846126646599352320 |
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| author | Chi Young Oh Eugene Kim Kihun Kim Hyeoncheol Oh Jung-Pil Yoon Tae Sik Goh Eunjeong Son Dai Sik Ko Yun Hak Kim |
| author_facet | Chi Young Oh Eugene Kim Kihun Kim Hyeoncheol Oh Jung-Pil Yoon Tae Sik Goh Eunjeong Son Dai Sik Ko Yun Hak Kim |
| author_sort | Chi Young Oh |
| collection | DOAJ |
| description | Background: Given the widespread prevalence of breast cancer as a global malignancy, there is a compelling need to delve into its risk determinants. Objective: This study aims to investigate the potential relationship between indicators of left-handedness and breast cancer, employing systematic review, meta-analysis, and Mendelian randomization methods. Design: Systematic review and meta-analysis. Methods: The systematic review and meta-analysis, encompassing case-control and cohort designs, conducted a database search on June 17, 2022, utilizing Medline and Embase. For Mendelian randomization analysis, the exposure variable, left-handedness, was sourced from the UK Biobank. Data for breast cancer outcomes were obtained from two cohorts: the Breast Cancer Association Consortium and the Finnish Biobank (Finngen). Results: Eight studies were included in the meta-analysis to investigate the correlation between left-handedness and breast cancer in females. The analysis of cohort studies revealed a hazard ratio (HR) of 1.21 (95% confidence interval (CI): 1.01–1.45), whereas case-control studies showed an odds ratio of 0.81 (95% CI: 0.52–1.26). Subgroup analysis indicated an elevated HR in premenopausal left-handed women. However, Mendelian randomization did not confirm a significant association. Conclusion: Our findings suggest a potential correlation between left-handedness and breast cancer, particularly in premenopausal women. However, due to limited studies and unclear supporting theories, definitive conclusions are premature. |
| format | Article |
| id | doaj-art-5be1b4ffb83c4a9e9a48a3f1aac0195c |
| institution | Kabale University |
| issn | 1758-8359 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Medical Oncology |
| spelling | doaj-art-5be1b4ffb83c4a9e9a48a3f1aac0195c2024-12-12T14:04:21ZengSAGE PublishingTherapeutic Advances in Medical Oncology1758-83592024-12-011610.1177/17588359241305096Exploring the handedness-breast cancer nexus: a comprehensive analysis via systematic review, meta-analysis, and Mendelian randomizationChi Young OhEugene KimKihun KimHyeoncheol OhJung-Pil YoonTae Sik GohEunjeong SonDai Sik KoYun Hak KimBackground: Given the widespread prevalence of breast cancer as a global malignancy, there is a compelling need to delve into its risk determinants. Objective: This study aims to investigate the potential relationship between indicators of left-handedness and breast cancer, employing systematic review, meta-analysis, and Mendelian randomization methods. Design: Systematic review and meta-analysis. Methods: The systematic review and meta-analysis, encompassing case-control and cohort designs, conducted a database search on June 17, 2022, utilizing Medline and Embase. For Mendelian randomization analysis, the exposure variable, left-handedness, was sourced from the UK Biobank. Data for breast cancer outcomes were obtained from two cohorts: the Breast Cancer Association Consortium and the Finnish Biobank (Finngen). Results: Eight studies were included in the meta-analysis to investigate the correlation between left-handedness and breast cancer in females. The analysis of cohort studies revealed a hazard ratio (HR) of 1.21 (95% confidence interval (CI): 1.01–1.45), whereas case-control studies showed an odds ratio of 0.81 (95% CI: 0.52–1.26). Subgroup analysis indicated an elevated HR in premenopausal left-handed women. However, Mendelian randomization did not confirm a significant association. Conclusion: Our findings suggest a potential correlation between left-handedness and breast cancer, particularly in premenopausal women. However, due to limited studies and unclear supporting theories, definitive conclusions are premature.https://doi.org/10.1177/17588359241305096 |
| spellingShingle | Chi Young Oh Eugene Kim Kihun Kim Hyeoncheol Oh Jung-Pil Yoon Tae Sik Goh Eunjeong Son Dai Sik Ko Yun Hak Kim Exploring the handedness-breast cancer nexus: a comprehensive analysis via systematic review, meta-analysis, and Mendelian randomization Therapeutic Advances in Medical Oncology |
| title | Exploring the handedness-breast cancer nexus: a comprehensive analysis via systematic review, meta-analysis, and Mendelian randomization |
| title_full | Exploring the handedness-breast cancer nexus: a comprehensive analysis via systematic review, meta-analysis, and Mendelian randomization |
| title_fullStr | Exploring the handedness-breast cancer nexus: a comprehensive analysis via systematic review, meta-analysis, and Mendelian randomization |
| title_full_unstemmed | Exploring the handedness-breast cancer nexus: a comprehensive analysis via systematic review, meta-analysis, and Mendelian randomization |
| title_short | Exploring the handedness-breast cancer nexus: a comprehensive analysis via systematic review, meta-analysis, and Mendelian randomization |
| title_sort | exploring the handedness breast cancer nexus a comprehensive analysis via systematic review meta analysis and mendelian randomization |
| url | https://doi.org/10.1177/17588359241305096 |
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