FASN promotes the stemness of cancer stem cells and protects colorectal cancer cells from ferroptosis by inhibiting the activation of SREBP2

FASN promotes the stemness of cancer stem cells and protects colorectal cancer cells from ferroptosis by inhibiting the activation of SREBP2

IntroductionFatty acid synthase (FASN) is a key regulator of lipid metabolism, but its role in colorectal cancer (CRC) stemness and ferroptosis remains unclear.MethodsFASN expression in CRC was analyzed using TCGA data and validated in CRC cell lines (CACO-2, HCT116, SW480) and normal HIEC-6 cells v...

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Bibliographic Details
Main Authors: Ming Wang, Fulin Ge, Cheng Wu, Binbin Su, Xiaoyu Dong, Shiping Xu, Hui Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
colorectal cancer
ferroptosis
FASN
lipid metabolism
cancer stem cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1611375/full
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