Bergenin, a bioactive flavonoid: advancements in the prospects of anticancer mechanism, pharmacokinetics and nanoformulations
The natural world is a vast reservoir of exceptionally varied and inventive chemical compositions. Natural products are used as initial compounds to create combinatorial libraries by targeted modifications and then by analyzing their structure-activity connections. This stage is regarded as a crucia...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1481587/full |
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| author | Pratibha Pandey Pratibha Pandey Sorabh Lakhanpal Danish Mahmood Han Na Kang Byunggyu Kim Sojin Kang Jinwon Choi Seungjoon Moon Shivam Pandey Suhas Ballal Sanjay Kumar Fahad Khan Bonglee Kim |
| author_facet | Pratibha Pandey Pratibha Pandey Sorabh Lakhanpal Danish Mahmood Han Na Kang Byunggyu Kim Sojin Kang Jinwon Choi Seungjoon Moon Shivam Pandey Suhas Ballal Sanjay Kumar Fahad Khan Bonglee Kim |
| author_sort | Pratibha Pandey |
| collection | DOAJ |
| description | The natural world is a vast reservoir of exceptionally varied and inventive chemical compositions. Natural products are used as initial compounds to create combinatorial libraries by targeted modifications and then by analyzing their structure-activity connections. This stage is regarded as a crucial milestone in drug discovery and development. Bergenin, a naturally occurring secondary metabolite, has been extracted from several plant components. It is a constituent found in herbal and Ayurvedic preparations. It demonstrates antiviral, antifungal, antitussive, antiplasmodial, anti-inflammatory, antihepatotoxic, antiarrhythmic, antitumor, antiulcerogenic, antidiabetic, and wound healing activities. Bergenin efficiently inhibited the proliferation of human cancer cells by stimulating the production of intracellular reactive oxygen species (ROS), causing DNA damage and leading to cell cycle arrest in the G1/G2 phases by blocking cell signaling pathways. More comprehensive reviews are needed on the anticancer properties of bergenin. Therefore, our review aimed to update the multifaceted benefits of bergenin to the future scientists and researchers, which can be leveraged to formulate safer and novel cancer therapies, while also establishing a robust framework for future investigations into bergenin in cancer treatment. More preclinical and clinical investigations are needed to validate the candidature of bergenin as a potent anticancer agent. |
| format | Article |
| id | doaj-art-5baf3d6da4024c16b5114463fd7e5117 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-5baf3d6da4024c16b5114463fd7e51172025-01-06T06:58:59ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.14815871481587Bergenin, a bioactive flavonoid: advancements in the prospects of anticancer mechanism, pharmacokinetics and nanoformulationsPratibha Pandey0Pratibha Pandey1Sorabh Lakhanpal2Danish Mahmood3Han Na Kang4Byunggyu Kim5Sojin Kang6Jinwon Choi7Seungjoon Moon8Shivam Pandey9Suhas Ballal10Sanjay Kumar11Fahad Khan12Bonglee Kim13Centre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, IndiaChitkara Centre for Research and Development, Chitkara University Himanchal Pradesh, Baddi, IndiaSchool of Pharmaceutical Sciences, Lovely Professional University, Phagwara, IndiaDepartment of Pharmacology and Toxicology, College of Pharmacy, Qassim University, Buraydah, Saudi ArabiaKM Convergence Research Division, Korea Institute of Oriental Medicine, Daejeon, Republic of KoreaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaSchool of Applied and Life Sciences, Uttaranchal University, Dehradun, IndiaDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, IndiaDepartment of Allied Healthcare and Sciences, Vivekananda Global University, Rajasthan, India0Center for Global Health Research Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Chennai, IndiaDepartment of Pathology, College of Korean Medicine, Kyung Hee University, Seoul, Republic of KoreaThe natural world is a vast reservoir of exceptionally varied and inventive chemical compositions. Natural products are used as initial compounds to create combinatorial libraries by targeted modifications and then by analyzing their structure-activity connections. This stage is regarded as a crucial milestone in drug discovery and development. Bergenin, a naturally occurring secondary metabolite, has been extracted from several plant components. It is a constituent found in herbal and Ayurvedic preparations. It demonstrates antiviral, antifungal, antitussive, antiplasmodial, anti-inflammatory, antihepatotoxic, antiarrhythmic, antitumor, antiulcerogenic, antidiabetic, and wound healing activities. Bergenin efficiently inhibited the proliferation of human cancer cells by stimulating the production of intracellular reactive oxygen species (ROS), causing DNA damage and leading to cell cycle arrest in the G1/G2 phases by blocking cell signaling pathways. More comprehensive reviews are needed on the anticancer properties of bergenin. Therefore, our review aimed to update the multifaceted benefits of bergenin to the future scientists and researchers, which can be leveraged to formulate safer and novel cancer therapies, while also establishing a robust framework for future investigations into bergenin in cancer treatment. More preclinical and clinical investigations are needed to validate the candidature of bergenin as a potent anticancer agent.https://www.frontiersin.org/articles/10.3389/fphar.2024.1481587/fullbergeninanticancerpharmacokineticcancertherapeutics |
| spellingShingle | Pratibha Pandey Pratibha Pandey Sorabh Lakhanpal Danish Mahmood Han Na Kang Byunggyu Kim Sojin Kang Jinwon Choi Seungjoon Moon Shivam Pandey Suhas Ballal Sanjay Kumar Fahad Khan Bonglee Kim Bergenin, a bioactive flavonoid: advancements in the prospects of anticancer mechanism, pharmacokinetics and nanoformulations Frontiers in Pharmacology bergenin anticancer pharmacokinetic cancer therapeutics |
| title | Bergenin, a bioactive flavonoid: advancements in the prospects of anticancer mechanism, pharmacokinetics and nanoformulations |
| title_full | Bergenin, a bioactive flavonoid: advancements in the prospects of anticancer mechanism, pharmacokinetics and nanoformulations |
| title_fullStr | Bergenin, a bioactive flavonoid: advancements in the prospects of anticancer mechanism, pharmacokinetics and nanoformulations |
| title_full_unstemmed | Bergenin, a bioactive flavonoid: advancements in the prospects of anticancer mechanism, pharmacokinetics and nanoformulations |
| title_short | Bergenin, a bioactive flavonoid: advancements in the prospects of anticancer mechanism, pharmacokinetics and nanoformulations |
| title_sort | bergenin a bioactive flavonoid advancements in the prospects of anticancer mechanism pharmacokinetics and nanoformulations |
| topic | bergenin anticancer pharmacokinetic cancer therapeutics |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1481587/full |
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