Unlocking the potential for optic nerve regeneration over long distances: a multi-therapeutic intervention
Retinal ganglion cells (RGCs) generally fail to regenerate axons, resulting in irreversible vision loss after optic nerve injury. While many studies have shown that modulating specific genes can enhance RGCs survival and promote optic nerve regeneration, inducing long-distance axon regeneration in v...
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| Format: | Article |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1526973/full |
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| author | Zhen-Gang Liu Zhen-Gang Liu Lai-Yang Zhou Lai-Yang Zhou Lai-Yang Zhou Lai-Yang Zhou Yong-Quan Sun Yong-Quan Sun Yong-Quan Sun Yong-Quan Sun Yi-Hang Ma Chang-Mei Liu Chang-Mei Liu Chang-Mei Liu Chang-Mei Liu Bo-Yin Zhang |
| author_facet | Zhen-Gang Liu Zhen-Gang Liu Lai-Yang Zhou Lai-Yang Zhou Lai-Yang Zhou Lai-Yang Zhou Yong-Quan Sun Yong-Quan Sun Yong-Quan Sun Yong-Quan Sun Yi-Hang Ma Chang-Mei Liu Chang-Mei Liu Chang-Mei Liu Chang-Mei Liu Bo-Yin Zhang |
| author_sort | Zhen-Gang Liu |
| collection | DOAJ |
| description | Retinal ganglion cells (RGCs) generally fail to regenerate axons, resulting in irreversible vision loss after optic nerve injury. While many studies have shown that modulating specific genes can enhance RGCs survival and promote optic nerve regeneration, inducing long-distance axon regeneration in vivo through single-gene manipulation remains challenging. Nevertheless, combined multi-gene therapies have proven effective in significantly enhancing axonal regeneration. At present, research on promoting optic nerve regeneration remains slow, with most studies unable to achieve axonal growth beyond the optic chiasm or reestablish connections with the brain. Future research priorities include directing axonal growth along correct pathways, facilitating synapse formation and myelination, and modifying the inhibitory microenvironment. These strategies are crucial not only for optic nerve regeneration but also for broader applications in central nervous system repair. In this review, we discuss multifactors therapeutic strategies for optic nerve regeneration, offering insights into advancing nerve regeneration research. |
| format | Article |
| id | doaj-art-5b9de1ee234747f7866f77debb7c09a4 |
| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj-art-5b9de1ee234747f7866f77debb7c09a42025-01-09T08:51:38ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-01-011510.3389/fneur.2024.15269731526973Unlocking the potential for optic nerve regeneration over long distances: a multi-therapeutic interventionZhen-Gang Liu0Zhen-Gang Liu1Lai-Yang Zhou2Lai-Yang Zhou3Lai-Yang Zhou4Lai-Yang Zhou5Yong-Quan Sun6Yong-Quan Sun7Yong-Quan Sun8Yong-Quan Sun9Yi-Hang Ma10Chang-Mei Liu11Chang-Mei Liu12Chang-Mei Liu13Chang-Mei Liu14Bo-Yin Zhang15Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun, ChinaKey Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaKey Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaSavaid Medical School, University of Chinese Academy of Sciences, Beijing, ChinaInstitute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, ChinaBeijing Institute for Stem Cell and Regenerative Medicine, Beijing, ChinaKey Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaSavaid Medical School, University of Chinese Academy of Sciences, Beijing, ChinaInstitute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, ChinaBeijing Institute for Stem Cell and Regenerative Medicine, Beijing, ChinaDepartment of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun, ChinaKey Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaSavaid Medical School, University of Chinese Academy of Sciences, Beijing, ChinaInstitute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, ChinaBeijing Institute for Stem Cell and Regenerative Medicine, Beijing, ChinaDepartment of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun, ChinaRetinal ganglion cells (RGCs) generally fail to regenerate axons, resulting in irreversible vision loss after optic nerve injury. While many studies have shown that modulating specific genes can enhance RGCs survival and promote optic nerve regeneration, inducing long-distance axon regeneration in vivo through single-gene manipulation remains challenging. Nevertheless, combined multi-gene therapies have proven effective in significantly enhancing axonal regeneration. At present, research on promoting optic nerve regeneration remains slow, with most studies unable to achieve axonal growth beyond the optic chiasm or reestablish connections with the brain. Future research priorities include directing axonal growth along correct pathways, facilitating synapse formation and myelination, and modifying the inhibitory microenvironment. These strategies are crucial not only for optic nerve regeneration but also for broader applications in central nervous system repair. In this review, we discuss multifactors therapeutic strategies for optic nerve regeneration, offering insights into advancing nerve regeneration research.https://www.frontiersin.org/articles/10.3389/fneur.2024.1526973/fulloptic nerveaxon regenerationretinal ganglion cellsimmune microenvironmentmultiple genes |
| spellingShingle | Zhen-Gang Liu Zhen-Gang Liu Lai-Yang Zhou Lai-Yang Zhou Lai-Yang Zhou Lai-Yang Zhou Yong-Quan Sun Yong-Quan Sun Yong-Quan Sun Yong-Quan Sun Yi-Hang Ma Chang-Mei Liu Chang-Mei Liu Chang-Mei Liu Chang-Mei Liu Bo-Yin Zhang Unlocking the potential for optic nerve regeneration over long distances: a multi-therapeutic intervention Frontiers in Neurology optic nerve axon regeneration retinal ganglion cells immune microenvironment multiple genes |
| title | Unlocking the potential for optic nerve regeneration over long distances: a multi-therapeutic intervention |
| title_full | Unlocking the potential for optic nerve regeneration over long distances: a multi-therapeutic intervention |
| title_fullStr | Unlocking the potential for optic nerve regeneration over long distances: a multi-therapeutic intervention |
| title_full_unstemmed | Unlocking the potential for optic nerve regeneration over long distances: a multi-therapeutic intervention |
| title_short | Unlocking the potential for optic nerve regeneration over long distances: a multi-therapeutic intervention |
| title_sort | unlocking the potential for optic nerve regeneration over long distances a multi therapeutic intervention |
| topic | optic nerve axon regeneration retinal ganglion cells immune microenvironment multiple genes |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1526973/full |
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