Estrogen-mediated corneal collagen degradation in keratoconus

Estrogen-mediated corneal collagen degradation in keratoconus

Summary: Keratoconus (KC) is characterized by corneal thinning due to pathologic degradation of corneal stromal collagen. This study investigates the role of β-estradiol in corneal collagen degradation using both tear fluid samples from KC and non-KC patients and in vitro models (co-culture and 3D c...

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Bibliographic Details
Main Authors: Amit Chatterjee, Levi N. Kanu, Nikolay Boychev, Amy E. Ross, Vincent Yeung, Nandini Venkateswaran, Hajirah N. Saeed, Joseph.B. Ciolino
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Biochemistry
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225012659
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