Nature’s magic: how natural products work hand in hand with mitochondria to treat stroke
BackgroundMitochondria, as the energy factories of cells, are involved in a wide range of vital activities, including cell differentiation, signal transduction, the cell cycle, and apoptosis, while also regulating cell growth. However, current pharmacological treatments for stroke are challenged by...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2024.1434948/full |
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| author | Lin Cheng Shangbin Lv Chengkai Wei Sucheng Li Hao Liu Yong Chen Zhaoliang Luo Hongyan Cui |
| author_facet | Lin Cheng Shangbin Lv Chengkai Wei Sucheng Li Hao Liu Yong Chen Zhaoliang Luo Hongyan Cui |
| author_sort | Lin Cheng |
| collection | DOAJ |
| description | BackgroundMitochondria, as the energy factories of cells, are involved in a wide range of vital activities, including cell differentiation, signal transduction, the cell cycle, and apoptosis, while also regulating cell growth. However, current pharmacological treatments for stroke are challenged by issues such as drug resistance and side effects, necessitating the exploration of new therapeutic strategies.ObjectiveThis review aims to summarize the regulatory effects of natural compounds targeting mitochondria on neuronal mitochondrial function and metabolism, providing new perspectives for stroke treatment.Main findingsNumerous in vitro and in vivo studies have shown that natural products such as berberine, ginsenosides, and baicalein protect neuronal mitochondrial function and reduce stroke-induced damage through multiple mechanisms. These compounds reduce neuronal apoptosis by modulating the expression of mitochondrial-associated apoptotic proteins. They inhibit the activation of the mitochondrial permeability transition pore (mPTP), thereby decreasing ROS production and cytochrome C release, which helps preserve mitochondrial function. Additionally, they regulate ferroptosis, mitochondrial fission, and promote mitochondrial autophagy and trafficking, further enhancing neuronal protection.ConclusionAs multi-target chemical agents, natural products offer high efficacy with fewer side effects and present promising potential for innovative stroke therapies. Future research should further investigate the effectiveness and safety of these natural products in clinical applications, advancing their development as a new therapeutic strategy for stroke. |
| format | Article |
| id | doaj-art-5b96df5822594673a80d1447e2dfd304 |
| institution | Kabale University |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-5b96df5822594673a80d1447e2dfd3042025-01-07T06:45:30ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-01-011510.3389/fphar.2024.14349481434948Nature’s magic: how natural products work hand in hand with mitochondria to treat strokeLin Cheng0Shangbin Lv1Chengkai Wei2Sucheng Li3Hao Liu4Yong Chen5Zhaoliang Luo6Hongyan Cui7Department of Neurology, Chongqing Kaizhou Hospital of Traditional Chinese Medicine, Chongqing, ChinaChongqing Universty of Traditional Chinese Medicine, Chongqing, ChinaDepartment of Neurology, Chongqing Kaizhou Hospital of Traditional Chinese Medicine, Chongqing, ChinaDepartment of Neurology, Chongqing Kaizhou Hospital of Traditional Chinese Medicine, Chongqing, ChinaDepartment of Neurology, Chongqing Kaizhou Hospital of Traditional Chinese Medicine, Chongqing, ChinaDepartment of Neurology, Chongqing Kaizhou Hospital of Traditional Chinese Medicine, Chongqing, ChinaDepartment of Encephalopathy, Chongqing Traditional Chinese Medicine Hospital, Chongqing, ChinaDepartment of Rehabilitation Medicine, The Fifth People’s Hospital of Chongqing, Chongqing, ChinaBackgroundMitochondria, as the energy factories of cells, are involved in a wide range of vital activities, including cell differentiation, signal transduction, the cell cycle, and apoptosis, while also regulating cell growth. However, current pharmacological treatments for stroke are challenged by issues such as drug resistance and side effects, necessitating the exploration of new therapeutic strategies.ObjectiveThis review aims to summarize the regulatory effects of natural compounds targeting mitochondria on neuronal mitochondrial function and metabolism, providing new perspectives for stroke treatment.Main findingsNumerous in vitro and in vivo studies have shown that natural products such as berberine, ginsenosides, and baicalein protect neuronal mitochondrial function and reduce stroke-induced damage through multiple mechanisms. These compounds reduce neuronal apoptosis by modulating the expression of mitochondrial-associated apoptotic proteins. They inhibit the activation of the mitochondrial permeability transition pore (mPTP), thereby decreasing ROS production and cytochrome C release, which helps preserve mitochondrial function. Additionally, they regulate ferroptosis, mitochondrial fission, and promote mitochondrial autophagy and trafficking, further enhancing neuronal protection.ConclusionAs multi-target chemical agents, natural products offer high efficacy with fewer side effects and present promising potential for innovative stroke therapies. Future research should further investigate the effectiveness and safety of these natural products in clinical applications, advancing their development as a new therapeutic strategy for stroke.https://www.frontiersin.org/articles/10.3389/fphar.2024.1434948/fullmitochondriastrokeischaemic injurynatural productsneuronal protection |
| spellingShingle | Lin Cheng Shangbin Lv Chengkai Wei Sucheng Li Hao Liu Yong Chen Zhaoliang Luo Hongyan Cui Nature’s magic: how natural products work hand in hand with mitochondria to treat stroke Frontiers in Pharmacology mitochondria stroke ischaemic injury natural products neuronal protection |
| title | Nature’s magic: how natural products work hand in hand with mitochondria to treat stroke |
| title_full | Nature’s magic: how natural products work hand in hand with mitochondria to treat stroke |
| title_fullStr | Nature’s magic: how natural products work hand in hand with mitochondria to treat stroke |
| title_full_unstemmed | Nature’s magic: how natural products work hand in hand with mitochondria to treat stroke |
| title_short | Nature’s magic: how natural products work hand in hand with mitochondria to treat stroke |
| title_sort | nature s magic how natural products work hand in hand with mitochondria to treat stroke |
| topic | mitochondria stroke ischaemic injury natural products neuronal protection |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2024.1434948/full |
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