Risk factors for actinic keratosis, non‐melanoma skin cancer and cutaneous malignant melanoma in persons with and without Parkinson's disease: A cross‐sectional study
Abstract Background An epidemiological link between Parkinson's disease (PD) and cutaneous malignant melanoma (CMM) has been widely reported. The role of CMM risk factors in this association is unclear. Objectives To compare rates of risk factors for skin tumours, specifically actinic keratosis...
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | Skin Health and Disease |
| Online Access: | https://doi.org/10.1002/ski2.464 |
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| author | Esther Azizi Hana Feuerman Idit Peleg Felix Pavlotsky Zvi Segal Bernice Oberman Nirit Lev Emmilia Hodak Ruth Djaldetti Sharon Hassin‐Baer Rivka Inzelberg |
| author_facet | Esther Azizi Hana Feuerman Idit Peleg Felix Pavlotsky Zvi Segal Bernice Oberman Nirit Lev Emmilia Hodak Ruth Djaldetti Sharon Hassin‐Baer Rivka Inzelberg |
| author_sort | Esther Azizi |
| collection | DOAJ |
| description | Abstract Background An epidemiological link between Parkinson's disease (PD) and cutaneous malignant melanoma (CMM) has been widely reported. The role of CMM risk factors in this association is unclear. Objectives To compare rates of risk factors for skin tumours, specifically actinic keratosis (AK), non‐melanoma skin cancer (NMSC) and CMM, between persons with and without PD. Methods In this cross‐sectional observational study, patients attending tertiary PD clinics and community controls were interviewed for background/medical data and underwent dermatological examination. Logistic regression models assessed risk factors for skin tumours and their interactions with PD status. Results Included were 141 persons with PD and 155 controls; mean age 71.7 and 72.6 years, respectively. In both groups, the majority were males of Ashkenazi origin. Altogether, AK, basal cell carcinoma, squamous cell carcinoma and CMM were recorded in 76 (53.9%) persons with PD and 92 (59.3%) controls (NS). CMM prevalence predominated in PD patients. In the PD group, prolonged sun exposure (p = 0.007), freckles (p < 0.001) and solar lentigines (p = 0.008) were associated with skin tumours. In the control group, dysplastic atypical moles were negatively associated with skin tumours (p = 0.017). Logistic regression of the whole cohort showed that older age (p < 0.001), fair complexion (p = 0.04) and prolonged sun exposure (p = 0.01) were associated with skin tumours, but PD status was not independently associated, and no interactions were found between PD status and CMM risk factors. Conclusions Periodic dermatological screening of PD populations is mandatory, especially for carriers of major phenotypic risk factors or presenting with AK, NMSC or CMM. |
| format | Article |
| id | doaj-art-5b90d9e514e94df089487dfe7c9b463e |
| institution | Kabale University |
| issn | 2690-442X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Skin Health and Disease |
| spelling | doaj-art-5b90d9e514e94df089487dfe7c9b463e2024-12-02T04:03:51ZengWileySkin Health and Disease2690-442X2024-12-0146n/an/a10.1002/ski2.464Risk factors for actinic keratosis, non‐melanoma skin cancer and cutaneous malignant melanoma in persons with and without Parkinson's disease: A cross‐sectional studyEsther Azizi0Hana Feuerman1Idit Peleg2Felix Pavlotsky3Zvi Segal4Bernice Oberman5Nirit Lev6Emmilia Hodak7Ruth Djaldetti8Sharon Hassin‐Baer9Rivka Inzelberg10Department of Dermatology Chaim Sheba Medical Center Tel Hashomer IsraelFaculty of Medicine & Health Sciences Tel Aviv University Tel Aviv IsraelFaculty of Medicine & Health Sciences Tel Aviv University Tel Aviv IsraelDepartment of Dermatology Chaim Sheba Medical Center Tel Hashomer IsraelDepartment of Dermatology Chaim Sheba Medical Center Tel Hashomer IsraelFaculty of Medicine & Health Sciences Tel Aviv University Tel Aviv IsraelFaculty of Medicine & Health Sciences Tel Aviv University Tel Aviv IsraelFaculty of Medicine & Health Sciences Tel Aviv University Tel Aviv IsraelFaculty of Medicine & Health Sciences Tel Aviv University Tel Aviv IsraelFaculty of Medicine & Health Sciences Tel Aviv University Tel Aviv IsraelDepartment of Neurology and Neurosurgery Sagol School of Neuroscience The Faculty of Medicine & Health Sciences Tel Aviv University Tel Aviv IsraelAbstract Background An epidemiological link between Parkinson's disease (PD) and cutaneous malignant melanoma (CMM) has been widely reported. The role of CMM risk factors in this association is unclear. Objectives To compare rates of risk factors for skin tumours, specifically actinic keratosis (AK), non‐melanoma skin cancer (NMSC) and CMM, between persons with and without PD. Methods In this cross‐sectional observational study, patients attending tertiary PD clinics and community controls were interviewed for background/medical data and underwent dermatological examination. Logistic regression models assessed risk factors for skin tumours and their interactions with PD status. Results Included were 141 persons with PD and 155 controls; mean age 71.7 and 72.6 years, respectively. In both groups, the majority were males of Ashkenazi origin. Altogether, AK, basal cell carcinoma, squamous cell carcinoma and CMM were recorded in 76 (53.9%) persons with PD and 92 (59.3%) controls (NS). CMM prevalence predominated in PD patients. In the PD group, prolonged sun exposure (p = 0.007), freckles (p < 0.001) and solar lentigines (p = 0.008) were associated with skin tumours. In the control group, dysplastic atypical moles were negatively associated with skin tumours (p = 0.017). Logistic regression of the whole cohort showed that older age (p < 0.001), fair complexion (p = 0.04) and prolonged sun exposure (p = 0.01) were associated with skin tumours, but PD status was not independently associated, and no interactions were found between PD status and CMM risk factors. Conclusions Periodic dermatological screening of PD populations is mandatory, especially for carriers of major phenotypic risk factors or presenting with AK, NMSC or CMM.https://doi.org/10.1002/ski2.464 |
| spellingShingle | Esther Azizi Hana Feuerman Idit Peleg Felix Pavlotsky Zvi Segal Bernice Oberman Nirit Lev Emmilia Hodak Ruth Djaldetti Sharon Hassin‐Baer Rivka Inzelberg Risk factors for actinic keratosis, non‐melanoma skin cancer and cutaneous malignant melanoma in persons with and without Parkinson's disease: A cross‐sectional study Skin Health and Disease |
| title | Risk factors for actinic keratosis, non‐melanoma skin cancer and cutaneous malignant melanoma in persons with and without Parkinson's disease: A cross‐sectional study |
| title_full | Risk factors for actinic keratosis, non‐melanoma skin cancer and cutaneous malignant melanoma in persons with and without Parkinson's disease: A cross‐sectional study |
| title_fullStr | Risk factors for actinic keratosis, non‐melanoma skin cancer and cutaneous malignant melanoma in persons with and without Parkinson's disease: A cross‐sectional study |
| title_full_unstemmed | Risk factors for actinic keratosis, non‐melanoma skin cancer and cutaneous malignant melanoma in persons with and without Parkinson's disease: A cross‐sectional study |
| title_short | Risk factors for actinic keratosis, non‐melanoma skin cancer and cutaneous malignant melanoma in persons with and without Parkinson's disease: A cross‐sectional study |
| title_sort | risk factors for actinic keratosis non melanoma skin cancer and cutaneous malignant melanoma in persons with and without parkinson s disease a cross sectional study |
| url | https://doi.org/10.1002/ski2.464 |
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