The impact of perivascular adipose tissue characteristics on incident cardiovascular events in non-dialysis chronic kidney disease patients
IntroductionPatients with chronic kidney disease (CKD) face a high risk of developing cardiovascular disease. However, the relationship between perivascular adipose tissue characteristics and incident cardiovascular outcomes in non-dialysis patients with CKD remains unclear.MethodsThis was prospecti...
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Frontiers Media S.A.
2025-06-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1547007/full |
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| author | Shaozhen Feng Shaozhen Feng Zhiman Lai Miaorong Xue Miaorong Xue Wenjiao Zhu Wenjiao Zhu Qian Zhou Xiaojie Ke Xiaojie Ke Xingdi Guo Xingdi Guo Wei Chen Wei Chen Shurong Li Qunying Guo Qunying Guo |
| author_facet | Shaozhen Feng Shaozhen Feng Zhiman Lai Miaorong Xue Miaorong Xue Wenjiao Zhu Wenjiao Zhu Qian Zhou Xiaojie Ke Xiaojie Ke Xingdi Guo Xingdi Guo Wei Chen Wei Chen Shurong Li Qunying Guo Qunying Guo |
| author_sort | Shaozhen Feng |
| collection | DOAJ |
| description | IntroductionPatients with chronic kidney disease (CKD) face a high risk of developing cardiovascular disease. However, the relationship between perivascular adipose tissue characteristics and incident cardiovascular outcomes in non-dialysis patients with CKD remains unclear.MethodsThis was prospective, observational, cohort study. A total of 220 CKD patients (stages G2–G5) without prior cardiovascular disease were enrolled. Attenuations and volumes of peri-coronary adipose tissue (PCAT), thoracic peri-aortic adipose tissue (TAT), and epicardial adipose tissue (EAT) were measured by ECG-gated non-enhanced computed tomography scans. Total coronary artery (CAC) and thoracic aorta calcification (TAC) were quantified with Agatston scores.ResultsLower estimated glomerular filtration rate (eGFR) was associated with higher attenuation of PCAT, TAT, and EAT, but volumes differences across eGFR tertile were not significant. Multivariate analysis indicated that age and body mass index (BMI) were independently associated with PCAT, TAT, and EAT volumes. Smoking and serum phosphorus levels correlated with PCAT attenuation, while proteinuria, BMI, HDL cholesterol, and white blood cell counts were linked to TAT attenuation. EAT attenuations was associated with age, serum creatinine, proteinuria, BMI, smoking, and systolic blood pressure. During a median follow-up of 26.56 months, 23 patients developed cardiovascular events, with high EAT volume (≥129.14 cm3) or TAT volume (≥36.38 cm3) correlating with increased events rates. Cox regression demonstrated EAT volume as an independent predictor of incident cardiovascular outcomes. A multivariable model showed EAT volume enhanced the Framingham risk score's predictive value, achieving an area under the curve (AUC) of 0.76 (95% CI 0.66–0.87).ConclusionThese findings suggest EAT volume significantly predicts incident cardiovascular events in non-dialysis CKD patients. |
| format | Article |
| id | doaj-art-5b51fa00e389424e9478305cfa2b573a |
| institution | DOAJ |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-5b51fa00e389424e9478305cfa2b573a2025-08-20T03:21:39ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-06-011210.3389/fmed.2025.15470071547007The impact of perivascular adipose tissue characteristics on incident cardiovascular events in non-dialysis chronic kidney disease patientsShaozhen Feng0Shaozhen Feng1Zhiman Lai2Miaorong Xue3Miaorong Xue4Wenjiao Zhu5Wenjiao Zhu6Qian Zhou7Xiaojie Ke8Xiaojie Ke9Xingdi Guo10Xingdi Guo11Wei Chen12Wei Chen13Shurong Li14Qunying Guo15Qunying Guo16Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaNHC Key Laboratory of Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Guangzhou, ChinaDepartment of Radiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaDepartment of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaNHC Key Laboratory of Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Guangzhou, ChinaDepartment of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaNHC Key Laboratory of Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Guangzhou, ChinaDepartment of Medical Statistics, Clinical Trials Unit, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaDepartment of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaNHC Key Laboratory of Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Guangzhou, ChinaDepartment of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaNHC Key Laboratory of Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Guangzhou, ChinaDepartment of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaNHC Key Laboratory of Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Guangzhou, ChinaDepartment of Radiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaDepartment of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaNHC Key Laboratory of Nephrology (Sun Yat-sen University) and Guangdong Provincial Key Laboratory of Nephrology, Guangzhou, ChinaIntroductionPatients with chronic kidney disease (CKD) face a high risk of developing cardiovascular disease. However, the relationship between perivascular adipose tissue characteristics and incident cardiovascular outcomes in non-dialysis patients with CKD remains unclear.MethodsThis was prospective, observational, cohort study. A total of 220 CKD patients (stages G2–G5) without prior cardiovascular disease were enrolled. Attenuations and volumes of peri-coronary adipose tissue (PCAT), thoracic peri-aortic adipose tissue (TAT), and epicardial adipose tissue (EAT) were measured by ECG-gated non-enhanced computed tomography scans. Total coronary artery (CAC) and thoracic aorta calcification (TAC) were quantified with Agatston scores.ResultsLower estimated glomerular filtration rate (eGFR) was associated with higher attenuation of PCAT, TAT, and EAT, but volumes differences across eGFR tertile were not significant. Multivariate analysis indicated that age and body mass index (BMI) were independently associated with PCAT, TAT, and EAT volumes. Smoking and serum phosphorus levels correlated with PCAT attenuation, while proteinuria, BMI, HDL cholesterol, and white blood cell counts were linked to TAT attenuation. EAT attenuations was associated with age, serum creatinine, proteinuria, BMI, smoking, and systolic blood pressure. During a median follow-up of 26.56 months, 23 patients developed cardiovascular events, with high EAT volume (≥129.14 cm3) or TAT volume (≥36.38 cm3) correlating with increased events rates. Cox regression demonstrated EAT volume as an independent predictor of incident cardiovascular outcomes. A multivariable model showed EAT volume enhanced the Framingham risk score's predictive value, achieving an area under the curve (AUC) of 0.76 (95% CI 0.66–0.87).ConclusionThese findings suggest EAT volume significantly predicts incident cardiovascular events in non-dialysis CKD patients.https://www.frontiersin.org/articles/10.3389/fmed.2025.1547007/fullchronic kidney diseaseepicardial adipose tissueperi-coronary adipose tissuethoracic peri-aortic adipose tissueincident cardiovascular events |
| spellingShingle | Shaozhen Feng Shaozhen Feng Zhiman Lai Miaorong Xue Miaorong Xue Wenjiao Zhu Wenjiao Zhu Qian Zhou Xiaojie Ke Xiaojie Ke Xingdi Guo Xingdi Guo Wei Chen Wei Chen Shurong Li Qunying Guo Qunying Guo The impact of perivascular adipose tissue characteristics on incident cardiovascular events in non-dialysis chronic kidney disease patients Frontiers in Medicine chronic kidney disease epicardial adipose tissue peri-coronary adipose tissue thoracic peri-aortic adipose tissue incident cardiovascular events |
| title | The impact of perivascular adipose tissue characteristics on incident cardiovascular events in non-dialysis chronic kidney disease patients |
| title_full | The impact of perivascular adipose tissue characteristics on incident cardiovascular events in non-dialysis chronic kidney disease patients |
| title_fullStr | The impact of perivascular adipose tissue characteristics on incident cardiovascular events in non-dialysis chronic kidney disease patients |
| title_full_unstemmed | The impact of perivascular adipose tissue characteristics on incident cardiovascular events in non-dialysis chronic kidney disease patients |
| title_short | The impact of perivascular adipose tissue characteristics on incident cardiovascular events in non-dialysis chronic kidney disease patients |
| title_sort | impact of perivascular adipose tissue characteristics on incident cardiovascular events in non dialysis chronic kidney disease patients |
| topic | chronic kidney disease epicardial adipose tissue peri-coronary adipose tissue thoracic peri-aortic adipose tissue incident cardiovascular events |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1547007/full |
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