Retrospective multidisciplinary analysis of human alveolar echinococcosis in Hungary using spatial epidemiology approaches
Abstract Human alveolar echinococcosis (HAE), which is caused by the larval stage of the Echinococcus multilocularis tapeworm, is an increasing healthcare issue in Hungary. Among the 40 known cases in the country, 25 were detected in the last five years. Our study aimed to reveal the geographically...
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Nature Portfolio
2024-12-01
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| Online Access: | https://doi.org/10.1038/s41598-024-83119-7 |
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| author | Eszter Csulak Ágnes Csivincsik Tamás Sréter Norbert Solymosi József Danka Zsolt Káposztás Gábor Nagy Balázs Dezsényi |
| author_facet | Eszter Csulak Ágnes Csivincsik Tamás Sréter Norbert Solymosi József Danka Zsolt Káposztás Gábor Nagy Balázs Dezsényi |
| author_sort | Eszter Csulak |
| collection | DOAJ |
| description | Abstract Human alveolar echinococcosis (HAE), which is caused by the larval stage of the Echinococcus multilocularis tapeworm, is an increasing healthcare issue in Hungary. Among the 40 known cases in the country, 25 were detected in the last five years. Our study aimed to reveal the geographically underlying risk factors associated potentially with these cases. We investigated the spatial pattern and the impact of potential risk factors of HAE by cluster analysis, and local and global regression models. Also, a questionnaire survey on the patients’ lifestyle was implemented. We found two HAE hyperendemic foci in the country with very dissimilar biotic and climatic features, and controversial impact of different environmental factors. Four factors, viz. forest cover (β = 0.291, p < 0.0001), surface soil wetness (β = − 0.157, p = 0.033), fox infection rate (β = 0.369, p < 0.0001) and socio-economic development (β = − 0.216, p = 0.009), proved important countrywide. The most forested and the least developed districts showed the highest HAE risk. Among the patients, kitchen gardening (67.86%) and dog ownership (67.86%) seemed the riskiest activities. Our models detected an anomaly in one of the poorest regions of Hungary where all risk factors behaved contrary to that of the neighboring areas. This phenomenon was supposed to be the result of under-detection of the disease, and it called attention to the urgent priority of knowledge dissemination to the public and the healthcare professionals. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-5b440df16b6f43e8a2182f035ad048c02024-12-29T12:16:17ZengNature PortfolioScientific Reports2045-23222024-12-0114111710.1038/s41598-024-83119-7Retrospective multidisciplinary analysis of human alveolar echinococcosis in Hungary using spatial epidemiology approachesEszter Csulak0Ágnes Csivincsik1Tamás Sréter2Norbert Solymosi3József Danka4Zsolt Káposztás5Gábor Nagy6Balázs Dezsényi7Department of Surgery, Somogy County Teaching HospitalDepartment of Physiology and Animal Health, Hungarian University of Agriculture and Life SciencesLaboratory Department of Bacteriology, Mycology and Parasitology, National Center for Public Health and PharmacyCentre for Bioinformatics, University of Veterinary MedicineLaboratory Department of Bacteriology, Mycology and Parasitology, National Center for Public Health and PharmacyDepartment of Surgery, Somogy County Teaching HospitalDepartment of Physiology and Animal Health, Hungarian University of Agriculture and Life SciencesDepartment of Surgery, Transplantation and Gastroenterology, Semmelweis UniversityAbstract Human alveolar echinococcosis (HAE), which is caused by the larval stage of the Echinococcus multilocularis tapeworm, is an increasing healthcare issue in Hungary. Among the 40 known cases in the country, 25 were detected in the last five years. Our study aimed to reveal the geographically underlying risk factors associated potentially with these cases. We investigated the spatial pattern and the impact of potential risk factors of HAE by cluster analysis, and local and global regression models. Also, a questionnaire survey on the patients’ lifestyle was implemented. We found two HAE hyperendemic foci in the country with very dissimilar biotic and climatic features, and controversial impact of different environmental factors. Four factors, viz. forest cover (β = 0.291, p < 0.0001), surface soil wetness (β = − 0.157, p = 0.033), fox infection rate (β = 0.369, p < 0.0001) and socio-economic development (β = − 0.216, p = 0.009), proved important countrywide. The most forested and the least developed districts showed the highest HAE risk. Among the patients, kitchen gardening (67.86%) and dog ownership (67.86%) seemed the riskiest activities. Our models detected an anomaly in one of the poorest regions of Hungary where all risk factors behaved contrary to that of the neighboring areas. This phenomenon was supposed to be the result of under-detection of the disease, and it called attention to the urgent priority of knowledge dissemination to the public and the healthcare professionals.https://doi.org/10.1038/s41598-024-83119-7Human alveolar echinococcosisEchinococcus multilocularisSpatial epidemiologyCulture of povertyHungary |
| spellingShingle | Eszter Csulak Ágnes Csivincsik Tamás Sréter Norbert Solymosi József Danka Zsolt Káposztás Gábor Nagy Balázs Dezsényi Retrospective multidisciplinary analysis of human alveolar echinococcosis in Hungary using spatial epidemiology approaches Scientific Reports Human alveolar echinococcosis Echinococcus multilocularis Spatial epidemiology Culture of poverty Hungary |
| title | Retrospective multidisciplinary analysis of human alveolar echinococcosis in Hungary using spatial epidemiology approaches |
| title_full | Retrospective multidisciplinary analysis of human alveolar echinococcosis in Hungary using spatial epidemiology approaches |
| title_fullStr | Retrospective multidisciplinary analysis of human alveolar echinococcosis in Hungary using spatial epidemiology approaches |
| title_full_unstemmed | Retrospective multidisciplinary analysis of human alveolar echinococcosis in Hungary using spatial epidemiology approaches |
| title_short | Retrospective multidisciplinary analysis of human alveolar echinococcosis in Hungary using spatial epidemiology approaches |
| title_sort | retrospective multidisciplinary analysis of human alveolar echinococcosis in hungary using spatial epidemiology approaches |
| topic | Human alveolar echinococcosis Echinococcus multilocularis Spatial epidemiology Culture of poverty Hungary |
| url | https://doi.org/10.1038/s41598-024-83119-7 |
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