Defective removal of invariant chain peptides from MHC class II suppresses tumor antigen presentation and promotes tumor growth

Defective removal of invariant chain peptides from MHC class II suppresses tumor antigen presentation and promotes tumor growth

Summary: Tumor-draining lymph node dendritic cells (DCs) are poor stimulators of tumor antigen-specific CD4 T cells; however, the mechanism behind this defect is unclear. We now show that, in tumor-draining lymph node DCs, a large proportion of major histocompatibility complex class II (MHC-II) mole...

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Bibliographic Details
Main Authors: Joanna Bandola-Simon, Yoshinaga Ito, Kai W. Wucherpfennig, Paul A. Roche
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724015018
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