Study the relationship between serum lipid profile and bronchial asthma exacerbation
Background and aim Asthma is triggered by allergic and oxidative stress that starts lipid peroxidation with stimulation to release of arachidonic acid from cell membrane. This work aimed to study lipid profiles in bronchial asthma and to assess its use as a biomarker for its exacerbation. Patients a...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-04-01
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| Series: | Al-Azhar Assiut Medical Journal |
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| Online Access: | https://journals.lww.com/10.4103/azmj.azmj_110_21 |
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| author | Israa S.M.M. Elkordi Manal R. Hafez Hoda A. Eid |
| author_facet | Israa S.M.M. Elkordi Manal R. Hafez Hoda A. Eid |
| author_sort | Israa S.M.M. Elkordi |
| collection | DOAJ |
| description | Background and aim
Asthma is triggered by allergic and oxidative stress that starts lipid peroxidation with stimulation to release of arachidonic acid from cell membrane.
This work aimed to study lipid profiles in bronchial asthma and to assess its use as a biomarker for its exacerbation.
Patients and methods
A total of 50 individuals with bronchial asthma participated in this case-control research. During both acute and stable asthma episodes, spirometric indices, arterial blood gasses, serum cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c) levels were examined.
Results
In the acute phase, HDL was lower and LDL-c was greater in serum than in the stable period. TG, TC, and LDL-c were negatively linked in the acute phase, whereas HDL-c was favorably correlated with all spirometric indices. TG, TC, and LDL were negatively correlated with PaO2 and positively correlated with HCO3. HDL-c positively correlated with O2 saturation and PaO2, and negatively correlated with PaCO2 and HCO3. The most significant risk factors for dyslipidemia in acute phase were O2 saturation, PaO2, FVC%, HCO3, Forced Expiratory Flow (FEF) 25–75%, PaCO2, forced expiratory volume /forced vital capacity ratio. Serum HDL-c could be used to discriminate between acute and stable phases with 64% sensitivity, 68% specificity, 66.7% positive predictive value and 56.4% negative predictive value. Serum LDL could be used to discriminate between acute and stable phases with 70% sensitivity, 64% specificity, 66% positive predictive value and 68.1% negative predictive value.
Conclusion
Lipid profile was altered in asthma exacerbation. HDL-c and LDL-c could be used to discriminate between acute and stable asthma phases. |
| format | Article |
| id | doaj-art-5b2f95ae2cc544959d19f81296b7bc94 |
| institution | Kabale University |
| issn | 1687-1693 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Al-Azhar Assiut Medical Journal |
| spelling | doaj-art-5b2f95ae2cc544959d19f81296b7bc942025-01-17T15:57:08ZengWolters Kluwer Medknow PublicationsAl-Azhar Assiut Medical Journal1687-16932024-04-01222828910.4103/azmj.azmj_110_21Study the relationship between serum lipid profile and bronchial asthma exacerbationIsraa S.M.M. ElkordiManal R. HafezHoda A. EidBackground and aim Asthma is triggered by allergic and oxidative stress that starts lipid peroxidation with stimulation to release of arachidonic acid from cell membrane. This work aimed to study lipid profiles in bronchial asthma and to assess its use as a biomarker for its exacerbation. Patients and methods A total of 50 individuals with bronchial asthma participated in this case-control research. During both acute and stable asthma episodes, spirometric indices, arterial blood gasses, serum cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c) levels were examined. Results In the acute phase, HDL was lower and LDL-c was greater in serum than in the stable period. TG, TC, and LDL-c were negatively linked in the acute phase, whereas HDL-c was favorably correlated with all spirometric indices. TG, TC, and LDL were negatively correlated with PaO2 and positively correlated with HCO3. HDL-c positively correlated with O2 saturation and PaO2, and negatively correlated with PaCO2 and HCO3. The most significant risk factors for dyslipidemia in acute phase were O2 saturation, PaO2, FVC%, HCO3, Forced Expiratory Flow (FEF) 25–75%, PaCO2, forced expiratory volume /forced vital capacity ratio. Serum HDL-c could be used to discriminate between acute and stable phases with 64% sensitivity, 68% specificity, 66.7% positive predictive value and 56.4% negative predictive value. Serum LDL could be used to discriminate between acute and stable phases with 70% sensitivity, 64% specificity, 66% positive predictive value and 68.1% negative predictive value. Conclusion Lipid profile was altered in asthma exacerbation. HDL-c and LDL-c could be used to discriminate between acute and stable asthma phases.https://journals.lww.com/10.4103/azmj.azmj_110_21bronchial asthma exacerbationdyslipidemiahypercholesterolemia |
| spellingShingle | Israa S.M.M. Elkordi Manal R. Hafez Hoda A. Eid Study the relationship between serum lipid profile and bronchial asthma exacerbation Al-Azhar Assiut Medical Journal bronchial asthma exacerbation dyslipidemia hypercholesterolemia |
| title | Study the relationship between serum lipid profile and bronchial asthma exacerbation |
| title_full | Study the relationship between serum lipid profile and bronchial asthma exacerbation |
| title_fullStr | Study the relationship between serum lipid profile and bronchial asthma exacerbation |
| title_full_unstemmed | Study the relationship between serum lipid profile and bronchial asthma exacerbation |
| title_short | Study the relationship between serum lipid profile and bronchial asthma exacerbation |
| title_sort | study the relationship between serum lipid profile and bronchial asthma exacerbation |
| topic | bronchial asthma exacerbation dyslipidemia hypercholesterolemia |
| url | https://journals.lww.com/10.4103/azmj.azmj_110_21 |
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