Iron deficiency in dogs suffering from atopic dermatitis
Abstract Background Iron-deficiency is associated with increased morbidity and mortality in non-communicable diseases. However, iron parameters are rarely assessed in dogs. Here, we aimed to assess and correlate iron parameters in dogs suffering from Canine Atopic Dermatitis (CAD) compared to non-at...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-11-01
|
| Series: | BMC Veterinary Research |
| Online Access: | https://doi.org/10.1186/s12917-024-04350-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846171883292065792 |
|---|---|
| author | Carolina Frizzo Ramos Pavlos G. Doulidis Nina Polakova Iwan A. Burgener Erika Jensen-Jarolim Giulia Cimarelli Lucia Panakova Franziska Roth-Walter |
| author_facet | Carolina Frizzo Ramos Pavlos G. Doulidis Nina Polakova Iwan A. Burgener Erika Jensen-Jarolim Giulia Cimarelli Lucia Panakova Franziska Roth-Walter |
| author_sort | Carolina Frizzo Ramos |
| collection | DOAJ |
| description | Abstract Background Iron-deficiency is associated with increased morbidity and mortality in non-communicable diseases. However, iron parameters are rarely assessed in dogs. Here, we aimed to assess and correlate iron parameters in dogs suffering from Canine Atopic Dermatitis (CAD) compared to non-atopic, healthy dogs. Results For this retrospective study, blood values and sera of 34 dogs with confirmed CAD were compared with 94 healthy non-atopic dogs. In our cohort, dogs with CAD had significantly lower mean corpuscular volume (MCV, ) mean corpuscular hemoglobin (MCH) but higher white blood cell counts due to increased levels of circulating neutrophils and monocytes. CAD patients also had elevated total protein and c-reactive protein (CRP), but lower albumin levels compared to our healthy control dogs, indicated low-grade inflammation in the CAD cohort. Spearman correlations associated negatively clinical symptom (CADESI-4/PVAS) with MCV; ceruloplasmin and hepcidin, but positively with serum iron. Only in the CAD-cohort, MCV, CRP and albumin-levels negatively affected serum iron-levels and were positively associated with ceruloplasmin. Linear regression analysis revealed that serum iron-levels in CAD subjects, were positively dependent on hematocrit (packed cell volume, PCV) and albumin, and negatively dependent with white blood cells and neutrophils numbers. In contrast, in the healthy cohort, hepcidin was the sole factor associated with serum iron. Conclusions A decreased iron status was associated with a higher symptom burden. Iron homeostasis differed markedly in healthy and atopic dermatitis dogs. CAD patients had depleted iron-stores and presented themselves with subclinical inflammation. |
| format | Article |
| id | doaj-art-5b24c3d7257642a59d0709e35e3a6bf5 |
| institution | Kabale University |
| issn | 1746-6148 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj-art-5b24c3d7257642a59d0709e35e3a6bf52024-11-10T12:30:01ZengBMCBMC Veterinary Research1746-61482024-11-0120111210.1186/s12917-024-04350-yIron deficiency in dogs suffering from atopic dermatitisCarolina Frizzo Ramos0Pavlos G. Doulidis1Nina Polakova2Iwan A. Burgener3Erika Jensen-Jarolim4Giulia Cimarelli5Lucia Panakova6Franziska Roth-Walter7Department for Companion Animals and Horses, Clinical Unit of Small Animals Internal Medicine, Dermatology, University of Veterinary Medicine ViennaDepartment for Companion Animals and Horses, Clinical Unit of Small Animals Internal Medicine, Dermatology, University of Veterinary Medicine ViennaDepartment for Companion Animals and Horses, Clinical Unit of Small Animals Internal Medicine, Dermatology, University of Veterinary Medicine ViennaDepartment for Companion Animals and Horses, Clinical Unit of Small Animals Internal Medicine, Dermatology, University of Veterinary Medicine ViennaMesserli Research Institute, Department of Interdisciplinary Life Sciences, University of Veterinary Medicine ViennaDomestication Lab, Department of Interdisciplinary Life Sciences, Konrad Lorenz Institute of Ethology, University of Veterinary Medicine ViennaDepartment for Companion Animals and Horses, Clinical Unit of Small Animals Internal Medicine, Dermatology, University of Veterinary Medicine ViennaMesserli Research Institute, Department of Interdisciplinary Life Sciences, University of Veterinary Medicine ViennaAbstract Background Iron-deficiency is associated with increased morbidity and mortality in non-communicable diseases. However, iron parameters are rarely assessed in dogs. Here, we aimed to assess and correlate iron parameters in dogs suffering from Canine Atopic Dermatitis (CAD) compared to non-atopic, healthy dogs. Results For this retrospective study, blood values and sera of 34 dogs with confirmed CAD were compared with 94 healthy non-atopic dogs. In our cohort, dogs with CAD had significantly lower mean corpuscular volume (MCV, ) mean corpuscular hemoglobin (MCH) but higher white blood cell counts due to increased levels of circulating neutrophils and monocytes. CAD patients also had elevated total protein and c-reactive protein (CRP), but lower albumin levels compared to our healthy control dogs, indicated low-grade inflammation in the CAD cohort. Spearman correlations associated negatively clinical symptom (CADESI-4/PVAS) with MCV; ceruloplasmin and hepcidin, but positively with serum iron. Only in the CAD-cohort, MCV, CRP and albumin-levels negatively affected serum iron-levels and were positively associated with ceruloplasmin. Linear regression analysis revealed that serum iron-levels in CAD subjects, were positively dependent on hematocrit (packed cell volume, PCV) and albumin, and negatively dependent with white blood cells and neutrophils numbers. In contrast, in the healthy cohort, hepcidin was the sole factor associated with serum iron. Conclusions A decreased iron status was associated with a higher symptom burden. Iron homeostasis differed markedly in healthy and atopic dermatitis dogs. CAD patients had depleted iron-stores and presented themselves with subclinical inflammation.https://doi.org/10.1186/s12917-024-04350-y |
| spellingShingle | Carolina Frizzo Ramos Pavlos G. Doulidis Nina Polakova Iwan A. Burgener Erika Jensen-Jarolim Giulia Cimarelli Lucia Panakova Franziska Roth-Walter Iron deficiency in dogs suffering from atopic dermatitis BMC Veterinary Research |
| title | Iron deficiency in dogs suffering from atopic dermatitis |
| title_full | Iron deficiency in dogs suffering from atopic dermatitis |
| title_fullStr | Iron deficiency in dogs suffering from atopic dermatitis |
| title_full_unstemmed | Iron deficiency in dogs suffering from atopic dermatitis |
| title_short | Iron deficiency in dogs suffering from atopic dermatitis |
| title_sort | iron deficiency in dogs suffering from atopic dermatitis |
| url | https://doi.org/10.1186/s12917-024-04350-y |
| work_keys_str_mv | AT carolinafrizzoramos irondeficiencyindogssufferingfromatopicdermatitis AT pavlosgdoulidis irondeficiencyindogssufferingfromatopicdermatitis AT ninapolakova irondeficiencyindogssufferingfromatopicdermatitis AT iwanaburgener irondeficiencyindogssufferingfromatopicdermatitis AT erikajensenjarolim irondeficiencyindogssufferingfromatopicdermatitis AT giuliacimarelli irondeficiencyindogssufferingfromatopicdermatitis AT luciapanakova irondeficiencyindogssufferingfromatopicdermatitis AT franziskarothwalter irondeficiencyindogssufferingfromatopicdermatitis |