A systematic review of the effectiveness and utility of Lyme disease prevention measures in Canada, the United States, and Europe
Abstract Background This systematic review aimed to assess the effectiveness of interventions which reduce human-tick encounters, prevent tick bites, and reduce the risk of Borrelia burgdorferi transmission, and to evaluate knowledge on the cost, environmental impact, social impact and acceptability...
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2025-07-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-025-11183-z |
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| author | Katarina Ost Michala Norman Ariane Dumas Tricia Corrin Lisa Waddell Renee Schryer Claudia Duguay Olivia Facchin Kate Zinszer Jean-Phillipe Rocheleau Catherine Bouchard Cécile Aenishaenslin Alison Krentel Cindy Feng Manisha A. Kulkarni |
| author_facet | Katarina Ost Michala Norman Ariane Dumas Tricia Corrin Lisa Waddell Renee Schryer Claudia Duguay Olivia Facchin Kate Zinszer Jean-Phillipe Rocheleau Catherine Bouchard Cécile Aenishaenslin Alison Krentel Cindy Feng Manisha A. Kulkarni |
| author_sort | Katarina Ost |
| collection | DOAJ |
| description | Abstract Background This systematic review aimed to assess the effectiveness of interventions which reduce human-tick encounters, prevent tick bites, and reduce the risk of Borrelia burgdorferi transmission, and to evaluate knowledge on the cost, environmental impact, social impact and acceptability, and public health impact of these interventions. Methods The search was conducted in Medline, Embase, Global Health, CAB Abstracts, Cochrane CENTRAL, Scopus, and Econlit for relevant literature in March 2022 and was updated in November 2024 and followed PRISMA guidelines for systematic reviews. Inclusion was applied at citation and full text, after which articles were assessed for risk of bias and data was extracted by two independent reviewers. Studies were summarized by intervention type (landscape management, host animal parasitism and movement, chemical/natural/botanical applications, personal protection) and a multi-study synthesis of tick suppression effects was conducted for interventions that reported the density of infected nymphs as the primary outcome. Results One hundred and twenty-seven studies published between 1977 and 2024 were included in this systematic review. Most studies (n = 62) were classified as host-targeted interventions. Twenty-five studies were included in the multi-study synthesis of tick suppression effects, which suggested that chemical tick control methods are the most effective and consistent intervention type with 93.8% mean suppression of questing nymphs. Conclusion While some strategies such as chemical acaricides were shown to have greater effectiveness, factors such as social acceptability and resistance, environmental impact, cost, and feasibility should be considered when selecting the most appropriate intervention to maximize the utility of the intervention. |
| format | Article |
| id | doaj-art-5b15674518264e4e80f8ee0f81d35d1f |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-5b15674518264e4e80f8ee0f81d35d1f2025-08-20T03:45:22ZengBMCBMC Infectious Diseases1471-23342025-07-0125112310.1186/s12879-025-11183-zA systematic review of the effectiveness and utility of Lyme disease prevention measures in Canada, the United States, and EuropeKatarina Ost0Michala Norman1Ariane Dumas2Tricia Corrin3Lisa Waddell4Renee Schryer5Claudia Duguay6Olivia Facchin7Kate Zinszer8Jean-Phillipe Rocheleau9Catherine Bouchard10Cécile Aenishaenslin11Alison Krentel12Cindy Feng13Manisha A. Kulkarni14School of Epidemiology and Public Health, University of OttawaSchool of Epidemiology and Public Health, University of OttawaPublic Health Risk Sciences Division | Division Sciences des risques pour la santé Publique, National Microbiology Laboratory | Laboratoire National de Microbiologie, Public Health Agency of Canada | Agence de la santé Publique du CanadaPublic Health Risk Sciences Division | Division Sciences des risques pour la santé Publique, National Microbiology Laboratory | Laboratoire National de Microbiologie, Public Health Agency of Canada | Agence de la santé Publique du CanadaPublic Health Risk Sciences Division | Division Sciences des risques pour la santé Publique, National Microbiology Laboratory | Laboratoire National de Microbiologie, Public Health Agency of Canada | Agence de la santé Publique du CanadaSchool of Epidemiology and Public Health, University of OttawaSchool of Epidemiology and Public Health, University of OttawaSchool of Epidemiology and Public Health, University of OttawaCanadian Lyme Disease Research NetworkCanadian Lyme Disease Research NetworkPublic Health Risk Sciences Division | Division Sciences des risques pour la santé Publique, National Microbiology Laboratory | Laboratoire National de Microbiologie, Public Health Agency of Canada | Agence de la santé Publique du CanadaCanadian Lyme Disease Research NetworkSchool of Epidemiology and Public Health, University of OttawaDalhousie UniversitySchool of Epidemiology and Public Health, University of OttawaAbstract Background This systematic review aimed to assess the effectiveness of interventions which reduce human-tick encounters, prevent tick bites, and reduce the risk of Borrelia burgdorferi transmission, and to evaluate knowledge on the cost, environmental impact, social impact and acceptability, and public health impact of these interventions. Methods The search was conducted in Medline, Embase, Global Health, CAB Abstracts, Cochrane CENTRAL, Scopus, and Econlit for relevant literature in March 2022 and was updated in November 2024 and followed PRISMA guidelines for systematic reviews. Inclusion was applied at citation and full text, after which articles were assessed for risk of bias and data was extracted by two independent reviewers. Studies were summarized by intervention type (landscape management, host animal parasitism and movement, chemical/natural/botanical applications, personal protection) and a multi-study synthesis of tick suppression effects was conducted for interventions that reported the density of infected nymphs as the primary outcome. Results One hundred and twenty-seven studies published between 1977 and 2024 were included in this systematic review. Most studies (n = 62) were classified as host-targeted interventions. Twenty-five studies were included in the multi-study synthesis of tick suppression effects, which suggested that chemical tick control methods are the most effective and consistent intervention type with 93.8% mean suppression of questing nymphs. Conclusion While some strategies such as chemical acaricides were shown to have greater effectiveness, factors such as social acceptability and resistance, environmental impact, cost, and feasibility should be considered when selecting the most appropriate intervention to maximize the utility of the intervention.https://doi.org/10.1186/s12879-025-11183-zSystematic reviewTick controlLyme disease controlMulti-study synthesisFeasibilityUtility |
| spellingShingle | Katarina Ost Michala Norman Ariane Dumas Tricia Corrin Lisa Waddell Renee Schryer Claudia Duguay Olivia Facchin Kate Zinszer Jean-Phillipe Rocheleau Catherine Bouchard Cécile Aenishaenslin Alison Krentel Cindy Feng Manisha A. Kulkarni A systematic review of the effectiveness and utility of Lyme disease prevention measures in Canada, the United States, and Europe BMC Infectious Diseases Systematic review Tick control Lyme disease control Multi-study synthesis Feasibility Utility |
| title | A systematic review of the effectiveness and utility of Lyme disease prevention measures in Canada, the United States, and Europe |
| title_full | A systematic review of the effectiveness and utility of Lyme disease prevention measures in Canada, the United States, and Europe |
| title_fullStr | A systematic review of the effectiveness and utility of Lyme disease prevention measures in Canada, the United States, and Europe |
| title_full_unstemmed | A systematic review of the effectiveness and utility of Lyme disease prevention measures in Canada, the United States, and Europe |
| title_short | A systematic review of the effectiveness and utility of Lyme disease prevention measures in Canada, the United States, and Europe |
| title_sort | systematic review of the effectiveness and utility of lyme disease prevention measures in canada the united states and europe |
| topic | Systematic review Tick control Lyme disease control Multi-study synthesis Feasibility Utility |
| url | https://doi.org/10.1186/s12879-025-11183-z |
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