Prevention is Better than Cure! Can We prevent Primary Immune Deficiency Diseases?

Severe immune deficiencies are often fatal in young childhood unless recognized and treated with a hematopoietic stem cell transplant (HSCT) timely. The majority of the immune deficiencies are monogenic diseases and may affect multiple children in the affected family. While diagnoses and treatment o...

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Bibliographic Details
Main Authors: Prerna Jhawar, Neha Singh, Sagar Bhattad
Format: Article
Language:English
Published: Jaypee Brothers Medical Publisher 2023-06-01
Series:Pediatric Infectious Disease
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Online Access:https://www.pidjournal.com/doi/PID/pdf/10.5005/jp-journals-10081-1391
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Summary:Severe immune deficiencies are often fatal in young childhood unless recognized and treated with a hematopoietic stem cell transplant (HSCT) timely. The majority of the immune deficiencies are monogenic diseases and may affect multiple children in the affected family. While diagnoses and treatment of the affected child are of immediate priority, preventing these diseases in subsequent pregnancies is paramount. In this paper, we discuss the importance and ways of antenatal detection of inborn errors of immunity (IEI) and present a few case scenarios highlighting the need to consider different modalities for the diagnosis of these diseases in the fetus.
ISSN:2582-4988