Characterization of a novel Leishmania antigen containing a repetitive domain and its potential use as a prophylactic and therapeutic vaccine

Characterization of a novel Leishmania antigen containing a repetitive domain and its potential use as a prophylactic and therapeutic vaccine

ABSTRACT Human visceral leishmaniasis (HVL) is the second most lethal tropical parasitic disease. Currently, no prophylactic or therapeutic vaccines exist for HVL. Thus, the development of an efficacious vaccine is still needed. We previously performed an immunoproteomics analysis on Leishmania amaz...

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Main Authors: Bianca de Oliveira, Wanessa M. Goes, Frederico C. Nascimento, Juliana B. T. Carnielli, Eden R. Ferreira, Alex Fiorini de Carvalho, Pablo Victor Mendes dos Reis, Milton Pereira, Tiago Queiroga Nery Ricotta, Liliane Martins dos Santos, Renan Pedra de Souza, Diego Esteban Cargnelutti, Jeremy C. Mottram, Santuza R. Teixeira, Ana Paula Fernandes, Ricardo T. Gazzinelli
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mSphere
Subjects:
vaccines
leishmaniasis
recombinant protein production
adjuvants
immune response
protein localization
Online Access:https://journals.asm.org/doi/10.1128/msphere.00097-25
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https://journals.asm.org/doi/10.1128/msphere.00097-25

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