Magnetic Targeting of Rhodamine-Labeled Superparamagnetic Liposomes to Solid Tumors: In Vivo Tracking by Fibered Confocal Fluorescence Microscopy
Polyethylene glycol (PEG)ylated and rhodamine-labeled liposomes loaded with maghemite nanocrystals provide a novel nanoscaled hybrid system for magnetic targeting to solid tumors in possible combination with double in vivo imaging by fluorescence microscopy and magnetic resonance imaging (MRI). Huma...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2007-03-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2007.00004 |
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| _version_ | 1841561853547773952 |
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| author | Marie-Sophie Martina Jean-Paul Fortin Laure Fournier Christine Ménager Florence Gazeau Olivier Clément Sylviane Lesieur |
| author_facet | Marie-Sophie Martina Jean-Paul Fortin Laure Fournier Christine Ménager Florence Gazeau Olivier Clément Sylviane Lesieur |
| author_sort | Marie-Sophie Martina |
| collection | DOAJ |
| description | Polyethylene glycol (PEG)ylated and rhodamine-labeled liposomes loaded with maghemite nanocrystals provide a novel nanoscaled hybrid system for magnetic targeting to solid tumors in possible combination with double in vivo imaging by fluorescence microscopy and magnetic resonance imaging (MRI). Human prostate adenocarcinoma tumors implanted in mice were used as a system model. A magnetic field gradient was produced at the tumor level by external apposition of a magnet. Noninvasive fibered confocal fluorescence microscopy was successfully used to track the liposomes in vivo within organs and tumor blood vessels. Active targeting to the magnet-exposed tumors was clearly shown, in agreement with previous MRI studies. The liposomes were driven and accumulated within the microvasculature through a process that preserved vesicle structure and content. |
| format | Article |
| id | doaj-art-5ab5b1d9211f4444b5c563d725fcf15a |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2007-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-5ab5b1d9211f4444b5c563d725fcf15a2025-01-03T01:22:55ZengSAGE PublishingMolecular Imaging1536-01212007-03-01610.2310/7290.2007.0000410.2310_7290.2007.00004Magnetic Targeting of Rhodamine-Labeled Superparamagnetic Liposomes to Solid Tumors: In Vivo Tracking by Fibered Confocal Fluorescence MicroscopyMarie-Sophie MartinaJean-Paul FortinLaure FournierChristine MénagerFlorence GazeauOlivier ClémentSylviane LesieurPolyethylene glycol (PEG)ylated and rhodamine-labeled liposomes loaded with maghemite nanocrystals provide a novel nanoscaled hybrid system for magnetic targeting to solid tumors in possible combination with double in vivo imaging by fluorescence microscopy and magnetic resonance imaging (MRI). Human prostate adenocarcinoma tumors implanted in mice were used as a system model. A magnetic field gradient was produced at the tumor level by external apposition of a magnet. Noninvasive fibered confocal fluorescence microscopy was successfully used to track the liposomes in vivo within organs and tumor blood vessels. Active targeting to the magnet-exposed tumors was clearly shown, in agreement with previous MRI studies. The liposomes were driven and accumulated within the microvasculature through a process that preserved vesicle structure and content.https://doi.org/10.2310/7290.2007.00004 |
| spellingShingle | Marie-Sophie Martina Jean-Paul Fortin Laure Fournier Christine Ménager Florence Gazeau Olivier Clément Sylviane Lesieur Magnetic Targeting of Rhodamine-Labeled Superparamagnetic Liposomes to Solid Tumors: In Vivo Tracking by Fibered Confocal Fluorescence Microscopy Molecular Imaging |
| title | Magnetic Targeting of Rhodamine-Labeled Superparamagnetic Liposomes to Solid Tumors: In Vivo Tracking by Fibered Confocal Fluorescence Microscopy |
| title_full | Magnetic Targeting of Rhodamine-Labeled Superparamagnetic Liposomes to Solid Tumors: In Vivo Tracking by Fibered Confocal Fluorescence Microscopy |
| title_fullStr | Magnetic Targeting of Rhodamine-Labeled Superparamagnetic Liposomes to Solid Tumors: In Vivo Tracking by Fibered Confocal Fluorescence Microscopy |
| title_full_unstemmed | Magnetic Targeting of Rhodamine-Labeled Superparamagnetic Liposomes to Solid Tumors: In Vivo Tracking by Fibered Confocal Fluorescence Microscopy |
| title_short | Magnetic Targeting of Rhodamine-Labeled Superparamagnetic Liposomes to Solid Tumors: In Vivo Tracking by Fibered Confocal Fluorescence Microscopy |
| title_sort | magnetic targeting of rhodamine labeled superparamagnetic liposomes to solid tumors in vivo tracking by fibered confocal fluorescence microscopy |
| url | https://doi.org/10.2310/7290.2007.00004 |
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