The association between white blood cell counts and metabolic health obesity among US adults
BackgroundThe correlation between white cell count and metabolically healthy obesity (MHO) remains elusive among obese American adults. This study endeavors to elucidate this association.MethodsThis study enrolled 6,580 obese patients from the National Health and Nutrition Examination Survey (NHANES...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2025.1458764/full |
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| author | Zhanbin Li Zhanbin Li Zhenyu Yao Zhenyu Yao Zhenyu Yao Qiaoran Liu Qiaoran Liu |
| author_facet | Zhanbin Li Zhanbin Li Zhenyu Yao Zhenyu Yao Zhenyu Yao Qiaoran Liu Qiaoran Liu |
| author_sort | Zhanbin Li |
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| description | BackgroundThe correlation between white cell count and metabolically healthy obesity (MHO) remains elusive among obese American adults. This study endeavors to elucidate this association.MethodsThis study enrolled 6,580 obese patients from the National Health and Nutrition Examination Survey (NHANES). Obesity phenotypes were defined by presence/absence of metabolic syndrome components. Weighted multivariate logistic regression analyses were used to assess the association between white cell count and MHO occurrence. Restricted cubic spline analysis characterized dose–response relationships, and stratified analyses explored these relationships across sociodemographic and lifestyle factors.ResultsIn this study, MHO prevalence is 11.9% among obese adults. The risk of MHO was inversely correlated with WBC [OR (95%): 0.81 (0.76, 0.86), p < 0.001], lymphocytes [OR (95%): 0.56 (0.47, 0.68), p < 0.001], monocytes [OR (95%): 0.41 (0.22, 0.75), p = 0.004], and neutrophils count [OR (95%): 0.82 (0.76, 0.88), p < 0.001]. WBC and neutrophils showed L-shaped associations, while lymphocytes, monocytes, and RBCs had linear patterns. Furthermore, stratified analyses demonstrated blood cell counts consistently predicted MHO risk across subgroups.ConclusionIn this study, we provide novel insights into the association between blood cell count and the presence of MHO among obese individuals. Blood cell count is an accessible biomarker for dynamically tracking the presence of MHO. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-5aa3bbb2ad6547108904926fffc05f7c2025-01-17T15:45:03ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011210.3389/fnut.2025.14587641458764The association between white blood cell counts and metabolic health obesity among US adultsZhanbin Li0Zhanbin Li1Zhenyu Yao2Zhenyu Yao3Zhenyu Yao4Qiaoran Liu5Qiaoran Liu6Department of General Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaKey Laboratory of Metabolism and Gastrointestinal Tumor, the First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, ChinaKey Laboratory of Endocrine Glucose & Lipids Metabolism and Brain Aging, Ministry of Education; Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, ChinaShandong Clinical Research Center of Diabetes and Metabolic Diseases, Jinan, Shandong, ChinaShandong Institute of Endocrine and Metabolic Diseases, Jinan, Shandong, ChinaDepartment of General Surgery, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Jinan, Shandong, ChinaKey Laboratory of Metabolism and Gastrointestinal Tumor, the First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, ChinaBackgroundThe correlation between white cell count and metabolically healthy obesity (MHO) remains elusive among obese American adults. This study endeavors to elucidate this association.MethodsThis study enrolled 6,580 obese patients from the National Health and Nutrition Examination Survey (NHANES). Obesity phenotypes were defined by presence/absence of metabolic syndrome components. Weighted multivariate logistic regression analyses were used to assess the association between white cell count and MHO occurrence. Restricted cubic spline analysis characterized dose–response relationships, and stratified analyses explored these relationships across sociodemographic and lifestyle factors.ResultsIn this study, MHO prevalence is 11.9% among obese adults. The risk of MHO was inversely correlated with WBC [OR (95%): 0.81 (0.76, 0.86), p < 0.001], lymphocytes [OR (95%): 0.56 (0.47, 0.68), p < 0.001], monocytes [OR (95%): 0.41 (0.22, 0.75), p = 0.004], and neutrophils count [OR (95%): 0.82 (0.76, 0.88), p < 0.001]. WBC and neutrophils showed L-shaped associations, while lymphocytes, monocytes, and RBCs had linear patterns. Furthermore, stratified analyses demonstrated blood cell counts consistently predicted MHO risk across subgroups.ConclusionIn this study, we provide novel insights into the association between blood cell count and the presence of MHO among obese individuals. Blood cell count is an accessible biomarker for dynamically tracking the presence of MHO.https://www.frontiersin.org/articles/10.3389/fnut.2025.1458764/fullblood cell countWBCRBCMHONHANES |
| spellingShingle | Zhanbin Li Zhanbin Li Zhenyu Yao Zhenyu Yao Zhenyu Yao Qiaoran Liu Qiaoran Liu The association between white blood cell counts and metabolic health obesity among US adults Frontiers in Nutrition blood cell count WBC RBC MHO NHANES |
| title | The association between white blood cell counts and metabolic health obesity among US adults |
| title_full | The association between white blood cell counts and metabolic health obesity among US adults |
| title_fullStr | The association between white blood cell counts and metabolic health obesity among US adults |
| title_full_unstemmed | The association between white blood cell counts and metabolic health obesity among US adults |
| title_short | The association between white blood cell counts and metabolic health obesity among US adults |
| title_sort | association between white blood cell counts and metabolic health obesity among us adults |
| topic | blood cell count WBC RBC MHO NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2025.1458764/full |
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