Prognostic value of positive lymph node ratio in oral cavity squamous cell carcinoma after neoadjuvant treatment: a retrospective real-world study
Abstract This study aimed to address the prognostic value of positive lymph node ratio for oral cavity squamous cell carcinoma (OCSCC) patients after neoadjuvant treatment, and build a prediction nomogram model. Patients with OCSCC with neoadjuvant treatment were retrieved from the Surveillance, Epi...
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Nature Portfolio
2025-05-01
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| author | Sufeng Fan Shunv Cai Yun Cheng Yimin Wu Wenmei Jiang |
| author_facet | Sufeng Fan Shunv Cai Yun Cheng Yimin Wu Wenmei Jiang |
| author_sort | Sufeng Fan |
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| description | Abstract This study aimed to address the prognostic value of positive lymph node ratio for oral cavity squamous cell carcinoma (OCSCC) patients after neoadjuvant treatment, and build a prediction nomogram model. Patients with OCSCC with neoadjuvant treatment were retrieved from the Surveillance, Epidemiology, and End Results database from 2004 to 2021. The primary outcome was overall survival (OS), and the second outcome was disease-specific survival (DSS). Kaplan–Meier and log-rank tests were used to analyze the survival outcomes. Univariable and multivariable analyses were conducted, and then a nomogram was constructed. A total of 419 were included in this study. The optimal cutoff value of the positive lymph node ratio (LNR) was 7.0%. The 5-year OS of patients with low LNR was significantly improved over those with high LNR (p < 0.0001). LNR > 7.0% (HR 50.7, 95% CI 19.7–130.5), and unmarried status (HR 1.33, 95% CI 1.03–1.70) were the independent risk factors for OS (all p < 0.05). LNR > 7.0% (HR 35.8, 95% CI 9.63–132.7), gum primary site (HR 0.330, 95% CI 0.132–0.827), and preoperative chemotherapy and radiotherapy (HR 2.91, 95% CI 1.78–4.73) were the independent risk factors for DSS (all p < 0.05). According to the nomogram, patients were stratified into the high-risk group and the low-risk group for OS and DSS. Patients in the low-risk group were predicted with superior survival (both p < 0.05). The LNR was an independent prognostic factor of the OS and DSS for OCSCC patients after neoadjuvant treatment. The tools may be valuable to guide multidisciplinary teams in making treatment decisions. |
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| language | English |
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| spelling | doaj-art-5a9a17f8aedf43fba5d99166a77a0a252025-08-20T03:48:18ZengNature PortfolioScientific Reports2045-23222025-05-0115111110.1038/s41598-025-03048-xPrognostic value of positive lymph node ratio in oral cavity squamous cell carcinoma after neoadjuvant treatment: a retrospective real-world studySufeng Fan0Shunv Cai1Yun Cheng2Yimin Wu3Wenmei Jiang4Department of Oncology, Henan Provincial People’s HospitalDepartment of Anaesthesiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of SciencesDepartment of Anaesthesiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of SciencesDepartment of Anaesthesiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of SciencesDepartment of Anaesthesiology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of SciencesAbstract This study aimed to address the prognostic value of positive lymph node ratio for oral cavity squamous cell carcinoma (OCSCC) patients after neoadjuvant treatment, and build a prediction nomogram model. Patients with OCSCC with neoadjuvant treatment were retrieved from the Surveillance, Epidemiology, and End Results database from 2004 to 2021. The primary outcome was overall survival (OS), and the second outcome was disease-specific survival (DSS). Kaplan–Meier and log-rank tests were used to analyze the survival outcomes. Univariable and multivariable analyses were conducted, and then a nomogram was constructed. A total of 419 were included in this study. The optimal cutoff value of the positive lymph node ratio (LNR) was 7.0%. The 5-year OS of patients with low LNR was significantly improved over those with high LNR (p < 0.0001). LNR > 7.0% (HR 50.7, 95% CI 19.7–130.5), and unmarried status (HR 1.33, 95% CI 1.03–1.70) were the independent risk factors for OS (all p < 0.05). LNR > 7.0% (HR 35.8, 95% CI 9.63–132.7), gum primary site (HR 0.330, 95% CI 0.132–0.827), and preoperative chemotherapy and radiotherapy (HR 2.91, 95% CI 1.78–4.73) were the independent risk factors for DSS (all p < 0.05). According to the nomogram, patients were stratified into the high-risk group and the low-risk group for OS and DSS. Patients in the low-risk group were predicted with superior survival (both p < 0.05). The LNR was an independent prognostic factor of the OS and DSS for OCSCC patients after neoadjuvant treatment. The tools may be valuable to guide multidisciplinary teams in making treatment decisions.https://doi.org/10.1038/s41598-025-03048-xOral cavity squamous cell carcinomaNeoadjuvant treatmentLymph node ratioOverall survivalNomogram |
| spellingShingle | Sufeng Fan Shunv Cai Yun Cheng Yimin Wu Wenmei Jiang Prognostic value of positive lymph node ratio in oral cavity squamous cell carcinoma after neoadjuvant treatment: a retrospective real-world study Scientific Reports Oral cavity squamous cell carcinoma Neoadjuvant treatment Lymph node ratio Overall survival Nomogram |
| title | Prognostic value of positive lymph node ratio in oral cavity squamous cell carcinoma after neoadjuvant treatment: a retrospective real-world study |
| title_full | Prognostic value of positive lymph node ratio in oral cavity squamous cell carcinoma after neoadjuvant treatment: a retrospective real-world study |
| title_fullStr | Prognostic value of positive lymph node ratio in oral cavity squamous cell carcinoma after neoadjuvant treatment: a retrospective real-world study |
| title_full_unstemmed | Prognostic value of positive lymph node ratio in oral cavity squamous cell carcinoma after neoadjuvant treatment: a retrospective real-world study |
| title_short | Prognostic value of positive lymph node ratio in oral cavity squamous cell carcinoma after neoadjuvant treatment: a retrospective real-world study |
| title_sort | prognostic value of positive lymph node ratio in oral cavity squamous cell carcinoma after neoadjuvant treatment a retrospective real world study |
| topic | Oral cavity squamous cell carcinoma Neoadjuvant treatment Lymph node ratio Overall survival Nomogram |
| url | https://doi.org/10.1038/s41598-025-03048-x |
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