Biologics and Small Molecules for Inflammatory Nail Disorders: A Narrative Review
Background: Inflammatory dermatological conditions, including psoriasis, lichen planus, eczema, and alopecia areata, are frequently accompanied by nail findings and can have a significant impact on quality of life. Biologic and small-molecule medications have been approved over the past several deca...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | Indian Dermatology Online Journal |
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| Online Access: | https://journals.lww.com/10.4103/idoj.idoj_445_24 |
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| _version_ | 1841554253186859008 |
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| author | Carrie A. Forman Shari R. Lipner |
| author_facet | Carrie A. Forman Shari R. Lipner |
| author_sort | Carrie A. Forman |
| collection | DOAJ |
| description | Background:
Inflammatory dermatological conditions, including psoriasis, lichen planus, eczema, and alopecia areata, are frequently accompanied by nail findings and can have a significant impact on quality of life. Biologic and small-molecule medications have been approved over the past several decades in treating patients with these inflammatory nail disorders. They may be used in conjunction with longstanding mainstays of treatment (topical and intralesional corticosteroids, topical vitamin D3 analogs).
Objectives:
Our objectives were to review biologic and small-molecule treatment efficacies for nail psoriasis and alopecia areata-associated nail dystrophy, including Janus kinase inhibitors, apremilast, tumor necrosis factor (TNF) inhibitors, interleukin (IL)-17 inhibitors, and IL-23 inhibitors.
Materials and Methods:
A comprehensive PubMed literature review of clinical research studies, narrative reviews, systematic reviews, and meta-analyses was performed.
Conclusion:
Many biologics and small molecules are effective in treating nail psoriasis and alopecia areata, with each requiring precautions for adverse events. Clinical trials for use of biologics and small molecules for nail lichen planus and atopic dermatitis have not been published to date. |
| format | Article |
| id | doaj-art-5a857c15fa6f4d00836ccdf8862b80cb |
| institution | Kabale University |
| issn | 2229-5178 2249-5673 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Dermatology Online Journal |
| spelling | doaj-art-5a857c15fa6f4d00836ccdf8862b80cb2025-01-08T15:33:59ZengWolters Kluwer Medknow PublicationsIndian Dermatology Online Journal2229-51782249-56732025-01-01161505810.4103/idoj.idoj_445_24Biologics and Small Molecules for Inflammatory Nail Disorders: A Narrative ReviewCarrie A. FormanShari R. LipnerBackground: Inflammatory dermatological conditions, including psoriasis, lichen planus, eczema, and alopecia areata, are frequently accompanied by nail findings and can have a significant impact on quality of life. Biologic and small-molecule medications have been approved over the past several decades in treating patients with these inflammatory nail disorders. They may be used in conjunction with longstanding mainstays of treatment (topical and intralesional corticosteroids, topical vitamin D3 analogs). Objectives: Our objectives were to review biologic and small-molecule treatment efficacies for nail psoriasis and alopecia areata-associated nail dystrophy, including Janus kinase inhibitors, apremilast, tumor necrosis factor (TNF) inhibitors, interleukin (IL)-17 inhibitors, and IL-23 inhibitors. Materials and Methods: A comprehensive PubMed literature review of clinical research studies, narrative reviews, systematic reviews, and meta-analyses was performed. Conclusion: Many biologics and small molecules are effective in treating nail psoriasis and alopecia areata, with each requiring precautions for adverse events. Clinical trials for use of biologics and small molecules for nail lichen planus and atopic dermatitis have not been published to date.https://journals.lww.com/10.4103/idoj.idoj_445_24alopecia areataatopic dermatitisdermatologyinterleukin-17interleukin-23janus kinase inhibitorslichen planusnail diseasesnail psoriasistnf inhibitors |
| spellingShingle | Carrie A. Forman Shari R. Lipner Biologics and Small Molecules for Inflammatory Nail Disorders: A Narrative Review Indian Dermatology Online Journal alopecia areata atopic dermatitis dermatology interleukin-17 interleukin-23 janus kinase inhibitors lichen planus nail diseases nail psoriasis tnf inhibitors |
| title | Biologics and Small Molecules for Inflammatory Nail Disorders: A Narrative Review |
| title_full | Biologics and Small Molecules for Inflammatory Nail Disorders: A Narrative Review |
| title_fullStr | Biologics and Small Molecules for Inflammatory Nail Disorders: A Narrative Review |
| title_full_unstemmed | Biologics and Small Molecules for Inflammatory Nail Disorders: A Narrative Review |
| title_short | Biologics and Small Molecules for Inflammatory Nail Disorders: A Narrative Review |
| title_sort | biologics and small molecules for inflammatory nail disorders a narrative review |
| topic | alopecia areata atopic dermatitis dermatology interleukin-17 interleukin-23 janus kinase inhibitors lichen planus nail diseases nail psoriasis tnf inhibitors |
| url | https://journals.lww.com/10.4103/idoj.idoj_445_24 |
| work_keys_str_mv | AT carrieaforman biologicsandsmallmoleculesforinflammatorynaildisordersanarrativereview AT sharirlipner biologicsandsmallmoleculesforinflammatorynaildisordersanarrativereview |