Versatility of megakaryocytes in homeostasis and disease
Megakaryocytes (MKs) constitute a small portion of bone marrow cells and are primarily responsible for producing platelets, which are essential for hemostasis and wound healing. Recent studies have revealed that MKs and platelets perform diverse functions in various physiological and pathological co...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health
2024-10-01
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| Series: | Blood Science |
| Online Access: | http://journals.lww.com/10.1097/BS9.0000000000000212 |
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| _version_ | 1846110320320315392 |
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| author | Daosong Wang Jiayi Xie Meng Zhao |
| author_facet | Daosong Wang Jiayi Xie Meng Zhao |
| author_sort | Daosong Wang |
| collection | DOAJ |
| description | Megakaryocytes (MKs) constitute a small portion of bone marrow cells and are primarily responsible for producing platelets, which are essential for hemostasis and wound healing. Recent studies have revealed that MKs and platelets perform diverse functions in various physiological and pathological contexts. This comprehensive review highlights the functional diversity of MKs beyond thrombopoiesis, including their roles in regulating hematopoietic stem cells, modulating immune responses, contributing to hematological malignancies, and influencing aging processes. |
| format | Article |
| id | doaj-art-5a77bb5f6f80490b8e7297c684352fa5 |
| institution | Kabale University |
| issn | 2543-6368 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wolters Kluwer Health |
| record_format | Article |
| series | Blood Science |
| spelling | doaj-art-5a77bb5f6f80490b8e7297c684352fa52024-12-24T09:45:53ZengWolters Kluwer HealthBlood Science2543-63682024-10-0164e0021210.1097/BS9.0000000000000212202410000-00014Versatility of megakaryocytes in homeostasis and diseaseDaosong Wang0Jiayi Xie1Meng Zhao2a RNA Biomedical Institute, Sun Yat-sen Memorial Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, Chinab Key Laboratory of Stem Cells and Tissue Engineering (Ministry of Education), Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, Chinab Key Laboratory of Stem Cells and Tissue Engineering (Ministry of Education), Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, ChinaMegakaryocytes (MKs) constitute a small portion of bone marrow cells and are primarily responsible for producing platelets, which are essential for hemostasis and wound healing. Recent studies have revealed that MKs and platelets perform diverse functions in various physiological and pathological contexts. This comprehensive review highlights the functional diversity of MKs beyond thrombopoiesis, including their roles in regulating hematopoietic stem cells, modulating immune responses, contributing to hematological malignancies, and influencing aging processes.http://journals.lww.com/10.1097/BS9.0000000000000212 |
| spellingShingle | Daosong Wang Jiayi Xie Meng Zhao Versatility of megakaryocytes in homeostasis and disease Blood Science |
| title | Versatility of megakaryocytes in homeostasis and disease |
| title_full | Versatility of megakaryocytes in homeostasis and disease |
| title_fullStr | Versatility of megakaryocytes in homeostasis and disease |
| title_full_unstemmed | Versatility of megakaryocytes in homeostasis and disease |
| title_short | Versatility of megakaryocytes in homeostasis and disease |
| title_sort | versatility of megakaryocytes in homeostasis and disease |
| url | http://journals.lww.com/10.1097/BS9.0000000000000212 |
| work_keys_str_mv | AT daosongwang versatilityofmegakaryocytesinhomeostasisanddisease AT jiayixie versatilityofmegakaryocytesinhomeostasisanddisease AT mengzhao versatilityofmegakaryocytesinhomeostasisanddisease |