Interleukin-6 as a Pan-Cancer Prognostic Inflammatory Biomarker: A Population-Based Study and Comprehensive Bioinformatics Analysis
Hailun Xie,1,* Lishuang Wei,1,* Guotian Ruan,2– 5 Heyang Zhang,2– 5 Hanping Shi1 1Department of Gastrointestinal and Gland Surgery, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 2Department of Gastrointestinal Surgery, Depart...
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Dove Medical Press
2025-01-01
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| Series: | Journal of Inflammation Research |
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| author | Xie H Wei L Ruan G Zhang H Shi H |
| author_facet | Xie H Wei L Ruan G Zhang H Shi H |
| author_sort | Xie H |
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| description | Hailun Xie,1,* Lishuang Wei,1,* Guotian Ruan,2– 5 Heyang Zhang,2– 5 Hanping Shi1 1Department of Gastrointestinal and Gland Surgery, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 2Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 3National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 4Key Laboratory of Cancer FSMP for State Market Regulation, Beijing, People’s Republic of China; 5Laboratory for Clinical Medicine, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hanping Shi, Department of Gastrointestinal and Gland Surgery, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China, Email shihp@ccmu.edu.cnPurpose: Interleukin-6 (IL-6) is a central factor linking inflammation to cancer. This study aimed to provide a comprehensive assessment of the prognostic value of IL-6 and its immunotherapeutic features using a population-based pan-cancer analysis and comprehensive bioinformatic analysis.Patients and Methods: In the cohort study, 540 patients were included to explore the prognostic value of serum IL-6 levels in cancer. The differential expression of IL-6 and its association with survival and immune cell infiltration were investigated using the TCGA database. The SangerBox database was used to analyze the correlation between IL-6 expression and immune checkpoint (ICP), tumor mutation burden (TMB), and microsatellite instability (MSI) in cancer. Genomic changes in the IL-6 levels were studied using the c-BioPortal database. The IL-6 co-expression network was analyzed using the LinkedOmics database.Results: Serum IL-6 is an independent prognostic factor for cancer, especially gastrointestinal cancers. Compared to other serum inflammatory markers, serum IL-6 is an optimal biomarker for cancer prognosis. A comprehensive bioinformatics analysis showed higher IL-6 expression in human cancers than in the paired normal tissues. The IL-6 expression is closely associated with prognosis, ICP, TMB, and MSI. In addition, it is also strongly correlated with tumor-infiltrating cells. IL-6 levels are significantly associated with the prognosis of stomach adenocarcinoma (STAD). The IL-6 co-expression network in STAD is mainly involved in regulating inflammatory pathways and cell communication.Conclusion: IL-6 is a potential prognostic and immune biomarker of cancer. Compared to other clinical inflammatory biomarkers, IL-6 demonstrates superior prognostic efficacy.Keywords: Interleukin-6, Prognostic marker, Bioinformatic analysis, STAD |
| format | Article |
| id | doaj-art-5a76c4f0247b4469a11ca564dda14ab6 |
| institution | Kabale University |
| issn | 1178-7031 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Journal of Inflammation Research |
| spelling | doaj-art-5a76c4f0247b4469a11ca564dda14ab62025-01-14T16:51:43ZengDove Medical PressJournal of Inflammation Research1178-70312025-01-01Volume 1857358799208Interleukin-6 as a Pan-Cancer Prognostic Inflammatory Biomarker: A Population-Based Study and Comprehensive Bioinformatics AnalysisXie HWei LRuan GZhang HShi HHailun Xie,1,* Lishuang Wei,1,* Guotian Ruan,2– 5 Heyang Zhang,2– 5 Hanping Shi1 1Department of Gastrointestinal and Gland Surgery, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China; 2Department of Gastrointestinal Surgery, Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing, People’s Republic of China; 3National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 4Key Laboratory of Cancer FSMP for State Market Regulation, Beijing, People’s Republic of China; 5Laboratory for Clinical Medicine, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hanping Shi, Department of Gastrointestinal and Gland Surgery, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People’s Republic of China, Email shihp@ccmu.edu.cnPurpose: Interleukin-6 (IL-6) is a central factor linking inflammation to cancer. This study aimed to provide a comprehensive assessment of the prognostic value of IL-6 and its immunotherapeutic features using a population-based pan-cancer analysis and comprehensive bioinformatic analysis.Patients and Methods: In the cohort study, 540 patients were included to explore the prognostic value of serum IL-6 levels in cancer. The differential expression of IL-6 and its association with survival and immune cell infiltration were investigated using the TCGA database. The SangerBox database was used to analyze the correlation between IL-6 expression and immune checkpoint (ICP), tumor mutation burden (TMB), and microsatellite instability (MSI) in cancer. Genomic changes in the IL-6 levels were studied using the c-BioPortal database. The IL-6 co-expression network was analyzed using the LinkedOmics database.Results: Serum IL-6 is an independent prognostic factor for cancer, especially gastrointestinal cancers. Compared to other serum inflammatory markers, serum IL-6 is an optimal biomarker for cancer prognosis. A comprehensive bioinformatics analysis showed higher IL-6 expression in human cancers than in the paired normal tissues. The IL-6 expression is closely associated with prognosis, ICP, TMB, and MSI. In addition, it is also strongly correlated with tumor-infiltrating cells. IL-6 levels are significantly associated with the prognosis of stomach adenocarcinoma (STAD). The IL-6 co-expression network in STAD is mainly involved in regulating inflammatory pathways and cell communication.Conclusion: IL-6 is a potential prognostic and immune biomarker of cancer. Compared to other clinical inflammatory biomarkers, IL-6 demonstrates superior prognostic efficacy.Keywords: Interleukin-6, Prognostic marker, Bioinformatic analysis, STADhttps://www.dovepress.com/interleukin-6-as-a-pan-cancer-prognostic-inflammatory-biomarker-a-popu-peer-reviewed-fulltext-article-JIRinterleukin-6prognostic markerbioinformatic analysisstad; |
| spellingShingle | Xie H Wei L Ruan G Zhang H Shi H Interleukin-6 as a Pan-Cancer Prognostic Inflammatory Biomarker: A Population-Based Study and Comprehensive Bioinformatics Analysis Journal of Inflammation Research interleukin-6 prognostic marker bioinformatic analysis stad; |
| title | Interleukin-6 as a Pan-Cancer Prognostic Inflammatory Biomarker: A Population-Based Study and Comprehensive Bioinformatics Analysis |
| title_full | Interleukin-6 as a Pan-Cancer Prognostic Inflammatory Biomarker: A Population-Based Study and Comprehensive Bioinformatics Analysis |
| title_fullStr | Interleukin-6 as a Pan-Cancer Prognostic Inflammatory Biomarker: A Population-Based Study and Comprehensive Bioinformatics Analysis |
| title_full_unstemmed | Interleukin-6 as a Pan-Cancer Prognostic Inflammatory Biomarker: A Population-Based Study and Comprehensive Bioinformatics Analysis |
| title_short | Interleukin-6 as a Pan-Cancer Prognostic Inflammatory Biomarker: A Population-Based Study and Comprehensive Bioinformatics Analysis |
| title_sort | interleukin 6 as a pan cancer prognostic inflammatory biomarker a population based study and comprehensive bioinformatics analysis |
| topic | interleukin-6 prognostic marker bioinformatic analysis stad; |
| url | https://www.dovepress.com/interleukin-6-as-a-pan-cancer-prognostic-inflammatory-biomarker-a-popu-peer-reviewed-fulltext-article-JIR |
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