High-dose glucocorticoids inducing hyperglycemia in patients with diabetes mellitus experiencing recurrent ischemic stroke attacks: A case report
Stroke is an acute and focal neurological syndrome characterized by clinical deficits resulting from vascular injuries such as infarction or hemorrhage in the central nervous system. Given the prevalence of multiple comorbidities among stroke patients, they often find themselves on more than five me...
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| Format: | Article |
| Language: | Indonesian |
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Poltekkes Kemenkes Yogyakarta
2024-05-01
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| Series: | Jurnal Teknologi Laboratorium |
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| Online Access: | https://teknolabjournal.com/index.php/Jtl/article/view/487 |
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| author | Fatimatuz Zahro Tita Sugesti Siska Hermawati M. Hari Pristantiningtyas Herya Putra Dharma Muhammad Muchlis Jainuri Erik Pratama Fauna Herawati Adji Prayitno Marisca Evalina Gondokesumo |
| author_facet | Fatimatuz Zahro Tita Sugesti Siska Hermawati M. Hari Pristantiningtyas Herya Putra Dharma Muhammad Muchlis Jainuri Erik Pratama Fauna Herawati Adji Prayitno Marisca Evalina Gondokesumo |
| author_sort | Fatimatuz Zahro |
| collection | DOAJ |
| description | Stroke is an acute and focal neurological syndrome characterized by clinical deficits resulting from vascular injuries such as infarction or hemorrhage in the central nervous system. Given the prevalence of multiple comorbidities among stroke patients, they often find themselves on more than five medications, falling into the category of polypharmacy. Beyond treatments aimed at improving stroke outcomes and managing comorbid conditions, the presence of additional diseases may necessitate new therapies, potentially leading to side effects that can intersect and exacerbate the existing disease. This case report aims to present instances of hyperglycemia in stroke patients undergoing high-dose glucocorticoid therapy and discuss potential strategies to address this issue. In this particular case, human insulin was selected to rapidly control the patient's hyperglycemic condition. Subsequently, adjustments to basal and bolus insulin doses were made based on the frequency of use and duration of action of the glucocorticoid, specifically methylprednisolone. In conclusion, the hyperglycemia induced by glucocorticoids was identified through postprandial sugar monitoring, necessitating treatment through modifications to basal and bolus insulin doses. Strategies for managing hyperglycemia should be tailored to the pharmacokinetics of glucocorticoids and insulin. |
| format | Article |
| id | doaj-art-5a64f8062c9b429aac2c1b411152acd1 |
| institution | Kabale University |
| issn | 2338-5634 2580-0191 |
| language | Indonesian |
| publishDate | 2024-05-01 |
| publisher | Poltekkes Kemenkes Yogyakarta |
| record_format | Article |
| series | Jurnal Teknologi Laboratorium |
| spelling | doaj-art-5a64f8062c9b429aac2c1b411152acd12025-01-03T15:40:12ZindPoltekkes Kemenkes YogyakartaJurnal Teknologi Laboratorium2338-56342580-01912024-05-0113181410.29238/teknolabjournal.v13i1.487439High-dose glucocorticoids inducing hyperglycemia in patients with diabetes mellitus experiencing recurrent ischemic stroke attacks: A case reportFatimatuz Zahro0Tita Sugesti1Siska Hermawati2M. Hari Pristantiningtyas3Herya Putra Dharma4Muhammad Muchlis5Jainuri Erik Pratama6Fauna Herawati7Adji Prayitno8Marisca Evalina Gondokesumo9Universitas SurabayaMardi Waluyo Regional Public HospitalMardi Waluyo Regional Public HospitalMardi Waluyo Regional Public HospitalMardi Waluyo Regional Public HospitalMardi Waluyo Regional Public HospitalDr. Kariadi Central General HospitalUniversitas SurabayaUniversitas SurabayaUniversitas SurabayaStroke is an acute and focal neurological syndrome characterized by clinical deficits resulting from vascular injuries such as infarction or hemorrhage in the central nervous system. Given the prevalence of multiple comorbidities among stroke patients, they often find themselves on more than five medications, falling into the category of polypharmacy. Beyond treatments aimed at improving stroke outcomes and managing comorbid conditions, the presence of additional diseases may necessitate new therapies, potentially leading to side effects that can intersect and exacerbate the existing disease. This case report aims to present instances of hyperglycemia in stroke patients undergoing high-dose glucocorticoid therapy and discuss potential strategies to address this issue. In this particular case, human insulin was selected to rapidly control the patient's hyperglycemic condition. Subsequently, adjustments to basal and bolus insulin doses were made based on the frequency of use and duration of action of the glucocorticoid, specifically methylprednisolone. In conclusion, the hyperglycemia induced by glucocorticoids was identified through postprandial sugar monitoring, necessitating treatment through modifications to basal and bolus insulin doses. Strategies for managing hyperglycemia should be tailored to the pharmacokinetics of glucocorticoids and insulin.https://teknolabjournal.com/index.php/Jtl/article/view/487stroke polypharmacy comorbidities |
| spellingShingle | Fatimatuz Zahro Tita Sugesti Siska Hermawati M. Hari Pristantiningtyas Herya Putra Dharma Muhammad Muchlis Jainuri Erik Pratama Fauna Herawati Adji Prayitno Marisca Evalina Gondokesumo High-dose glucocorticoids inducing hyperglycemia in patients with diabetes mellitus experiencing recurrent ischemic stroke attacks: A case report Jurnal Teknologi Laboratorium stroke polypharmacy comorbidities |
| title | High-dose glucocorticoids inducing hyperglycemia in patients with diabetes mellitus experiencing recurrent ischemic stroke attacks: A case report |
| title_full | High-dose glucocorticoids inducing hyperglycemia in patients with diabetes mellitus experiencing recurrent ischemic stroke attacks: A case report |
| title_fullStr | High-dose glucocorticoids inducing hyperglycemia in patients with diabetes mellitus experiencing recurrent ischemic stroke attacks: A case report |
| title_full_unstemmed | High-dose glucocorticoids inducing hyperglycemia in patients with diabetes mellitus experiencing recurrent ischemic stroke attacks: A case report |
| title_short | High-dose glucocorticoids inducing hyperglycemia in patients with diabetes mellitus experiencing recurrent ischemic stroke attacks: A case report |
| title_sort | high dose glucocorticoids inducing hyperglycemia in patients with diabetes mellitus experiencing recurrent ischemic stroke attacks a case report |
| topic | stroke polypharmacy comorbidities |
| url | https://teknolabjournal.com/index.php/Jtl/article/view/487 |
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