Pulmonary Aspergillosis: An Observation from a Tertiary Care Hospital of Western Uttar Pradesh
Background: Aspergillus is the most frequently occurring fungal infection in immunocompromised patients with a high mortality rate. Invasive pulmonary aspergillosis is the most serious entity on the spectrum of pulmonary aspergillosis. Limited studies on the occurrence of pulmonary aspergillosis fro...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-11-01
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| Series: | Medical Journal of Dr. D.Y. Patil Vidyapeeth |
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| Online Access: | https://journals.lww.com/10.4103/mjdrdypu.mjdrdypu_921_23 |
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| _version_ | 1846136019119767552 |
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| author | Zeba Naj Peetam Singh Anita Pandey |
| author_facet | Zeba Naj Peetam Singh Anita Pandey |
| author_sort | Zeba Naj |
| collection | DOAJ |
| description | Background:
Aspergillus is the most frequently occurring fungal infection in immunocompromised patients with a high mortality rate. Invasive pulmonary aspergillosis is the most serious entity on the spectrum of pulmonary aspergillosis. Limited studies on the occurrence of pulmonary aspergillosis from this geographical area prompted us to carry out this study.
Materials and Methods:
This hospital-based cross-sectional observational study was carried out in the Postgraduate Department of Microbiology of a tertiary care medical teaching hospital in western Uttar Pradesh for one year. A total of 1032 respiratory samples were subjected for isolation and identification of fungal pathogens by direct microscopic examination (KOH mount) and culture on Sabouraud dextrose agar.
Results:
The isolation rate of pulmonary aspergilli was 6.97%. The majority of the respiratory samples received were sputum 900 (87.2%) followed by bronchoalveolar lavage fluid 132 (12.7%). The pulmonary pathology was predominantly seen in the age group of 41–50 years (25%). Male patients (69%) were predominant. The majority of the samples (50%) were from the respiratory medicine ward followed by the respiratory medicine ICU (25%). Aspergillus fumigatus (58%) was the predominant species isolated followed by Aspergillus flavus (25%).
Conclusion:
Isolation of Aspergillus species from patients of pulmonary pathology needs to be correlated clinically to rule out colonization as they may need proper antifungal treatment. Indiscriminate use of antifungals may lead to the emergence of antifungal drug resistance. |
| format | Article |
| id | doaj-art-5a4f8d8c5d4c45b6957a63ea5e5d64bf |
| institution | Kabale University |
| issn | 2589-8302 2589-8310 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Dr. D.Y. Patil Vidyapeeth |
| spelling | doaj-art-5a4f8d8c5d4c45b6957a63ea5e5d64bf2024-12-09T09:31:30ZengWolters Kluwer Medknow PublicationsMedical Journal of Dr. D.Y. Patil Vidyapeeth2589-83022589-83102024-11-011761201120610.4103/mjdrdypu.mjdrdypu_921_23Pulmonary Aspergillosis: An Observation from a Tertiary Care Hospital of Western Uttar PradeshZeba NajPeetam SinghAnita PandeyBackground: Aspergillus is the most frequently occurring fungal infection in immunocompromised patients with a high mortality rate. Invasive pulmonary aspergillosis is the most serious entity on the spectrum of pulmonary aspergillosis. Limited studies on the occurrence of pulmonary aspergillosis from this geographical area prompted us to carry out this study. Materials and Methods: This hospital-based cross-sectional observational study was carried out in the Postgraduate Department of Microbiology of a tertiary care medical teaching hospital in western Uttar Pradesh for one year. A total of 1032 respiratory samples were subjected for isolation and identification of fungal pathogens by direct microscopic examination (KOH mount) and culture on Sabouraud dextrose agar. Results: The isolation rate of pulmonary aspergilli was 6.97%. The majority of the respiratory samples received were sputum 900 (87.2%) followed by bronchoalveolar lavage fluid 132 (12.7%). The pulmonary pathology was predominantly seen in the age group of 41–50 years (25%). Male patients (69%) were predominant. The majority of the samples (50%) were from the respiratory medicine ward followed by the respiratory medicine ICU (25%). Aspergillus fumigatus (58%) was the predominant species isolated followed by Aspergillus flavus (25%). Conclusion: Isolation of Aspergillus species from patients of pulmonary pathology needs to be correlated clinically to rule out colonization as they may need proper antifungal treatment. Indiscriminate use of antifungals may lead to the emergence of antifungal drug resistance.https://journals.lww.com/10.4103/mjdrdypu.mjdrdypu_921_23aspergillosisaspergillusinvasive pulmonary aspergillosispulmonary aspergillosis |
| spellingShingle | Zeba Naj Peetam Singh Anita Pandey Pulmonary Aspergillosis: An Observation from a Tertiary Care Hospital of Western Uttar Pradesh Medical Journal of Dr. D.Y. Patil Vidyapeeth aspergillosis aspergillus invasive pulmonary aspergillosis pulmonary aspergillosis |
| title | Pulmonary Aspergillosis: An Observation from a Tertiary Care Hospital of Western Uttar Pradesh |
| title_full | Pulmonary Aspergillosis: An Observation from a Tertiary Care Hospital of Western Uttar Pradesh |
| title_fullStr | Pulmonary Aspergillosis: An Observation from a Tertiary Care Hospital of Western Uttar Pradesh |
| title_full_unstemmed | Pulmonary Aspergillosis: An Observation from a Tertiary Care Hospital of Western Uttar Pradesh |
| title_short | Pulmonary Aspergillosis: An Observation from a Tertiary Care Hospital of Western Uttar Pradesh |
| title_sort | pulmonary aspergillosis an observation from a tertiary care hospital of western uttar pradesh |
| topic | aspergillosis aspergillus invasive pulmonary aspergillosis pulmonary aspergillosis |
| url | https://journals.lww.com/10.4103/mjdrdypu.mjdrdypu_921_23 |
| work_keys_str_mv | AT zebanaj pulmonaryaspergillosisanobservationfromatertiarycarehospitalofwesternuttarpradesh AT peetamsingh pulmonaryaspergillosisanobservationfromatertiarycarehospitalofwesternuttarpradesh AT anitapandey pulmonaryaspergillosisanobservationfromatertiarycarehospitalofwesternuttarpradesh |