MORC2 is a phosphorylation-dependent DNA compaction machine

MORC2 is a phosphorylation-dependent DNA compaction machine

Abstract The Microrchidia (MORC) family of chromatin-remodelling ATPases is pivotal in forming higher-order chromatin structures that suppress transcription. The exact mechanisms of MORC-induced chromatin remodelling have been elusive. Here, we report an in vitro reconstitution of full-length MORC2,...

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Main Authors: Winnie Tan, Jeongveen Park, Hariprasad Venugopal, Jieqiong Lou, Prabavi Shayana Dias, Pedro L. Baldoni, Kyoung-Wook Moon, Toby A. Dite, Christine R. Keenan, Alexandra D. Gurzau, Joonyoung Lee, Timothy M. Johanson, Andrew Leis, Jumana Yousef, Vineet Vaibhav, Laura F. Dagley, Ching-Seng Ang, Laura D. Corso, Chen Davidovich, Stephin J. Vervoort, Gordon K. Smyth, Marnie E. Blewitt, Rhys S. Allan, Elizabeth Hinde, Sheena D’Arcy, Je-Kyung Ryu, Shabih Shakeel
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60751-z
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