Perforin-2 is dispensable for host defense against Aspergillus fumigatus and Candida albicans

Perforin-2 is dispensable for host defense against Aspergillus fumigatus and Candida albicans

ABSTRACT Myeloid phagocytes are essential for antifungal immunity against pulmonary Aspergillus fumigatus and systemic Candida albicans infections. However, the molecular mechanisms underlying fungal clearance by phagocytes remain incompletely understood. In this study, we investigated the role of P...

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Bibliographic Details
Main Authors: Mariano A. Aufiero, Li-Yin Hung, De'Broski R. Herbert, Tobias M. Hohl
Format: Article
Language:English
Published: American Society for Microbiology 2025-01-01
Series:mSphere
Subjects:
Aspergillus fumigatus
innate immunity
Candida albicans
Perforin
neutrophil
fungi
Online Access:https://journals.asm.org/doi/10.1128/msphere.00803-24
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