Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia: a population-based cross-sectional analysis
Abstract Background An increase in choroid plexus (CP) volume may be associated with cognitive decline in older individuals without dementia. In this study, we aimed to clarify whether CP volume can serve as an imaging marker of cognitive decline, determine how strongly CP volume is associated with...
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BMC
2024-12-01
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| Series: | Fluids and Barriers of the CNS |
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| Online Access: | https://doi.org/10.1186/s12987-024-00601-0 |
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| author | Yosuke Hidaka Mamoru Hashimoto Takashi Suehiro Ryuji Fukuhara Tomohisa Ishikawa Naoko Tsunoda Asuka Koyama Kazuki Honda Yusuke Miyagawa Kazuhiro Yoshiura Seiji Yuuki Naoto Kajitani Shuken Boku Kazunari Ishii Manabu Ikeda Minoru Takebayashi |
| author_facet | Yosuke Hidaka Mamoru Hashimoto Takashi Suehiro Ryuji Fukuhara Tomohisa Ishikawa Naoko Tsunoda Asuka Koyama Kazuki Honda Yusuke Miyagawa Kazuhiro Yoshiura Seiji Yuuki Naoto Kajitani Shuken Boku Kazunari Ishii Manabu Ikeda Minoru Takebayashi |
| author_sort | Yosuke Hidaka |
| collection | DOAJ |
| description | Abstract Background An increase in choroid plexus (CP) volume may be associated with cognitive decline in older individuals without dementia. In this study, we aimed to clarify whether CP volume can serve as an imaging marker of cognitive decline, determine how strongly CP volume is associated with cognitive decline, and explore factors associated with CP volume in older adults. Methods We measured CP volume, brain parenchyma, and cerebrospinal fluid (CSF) spaces associated with disproportionately enlarged subarachnoid space hydrocephalus (DESH), an imaging feature of normal-pressure hydrocephalus, in community-dwelling older adults aged ≥ 65 years without dementia. Results In 1,370 participants, lower Mini-Mental State Examination (MMSE) scores were significantly associated with higher CP volume, even after adjusting for DESH-related CSF space and brain parenchymal volume. CP volume was more strongly associated with MMSE scores than DESH-related CSF space and brain parenchymal volume. History of smoking, white matter hyperintensity, enlarged perivascular spaces, age, body mass index, and diabetes mellitus were also associated with increased CP volume. Conclusions CP volume may be a highly sensitive imaging marker of cognitive decline in community-dwelling older adults without dementia, as it is linked to cognitive decline independently of brain parenchyma and CSF volumes. Our findings emphasize the importance of investigating CP volume increase to maintain cognitive function in older individuals. Accordingly, further longitudinal studies are required. |
| format | Article |
| id | doaj-art-5a178aa8fdf64d4faa859f01612be81d |
| institution | Kabale University |
| issn | 2045-8118 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Fluids and Barriers of the CNS |
| spelling | doaj-art-5a178aa8fdf64d4faa859f01612be81d2024-12-22T12:42:37ZengBMCFluids and Barriers of the CNS2045-81182024-12-0121111010.1186/s12987-024-00601-0Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia: a population-based cross-sectional analysisYosuke Hidaka0Mamoru Hashimoto1Takashi Suehiro2Ryuji Fukuhara3Tomohisa Ishikawa4Naoko Tsunoda5Asuka Koyama6Kazuki Honda7Yusuke Miyagawa8Kazuhiro Yoshiura9Seiji Yuuki10Naoto Kajitani11Shuken Boku12Kazunari Ishii13Manabu Ikeda14Minoru Takebayashi15Department of Psychiatry, Osaka University Graduate School of MedicineDepartment of Neuropsychiatry, Faculty of Medicine, Kindai UniversityDepartment of Psychiatry, Osaka University Graduate School of MedicineDepartment of Psychiatry, Kagoshima University Graduate School of Medical and Dental SciencesDepartment of Psychiatry, Arao Kokoronosato HospitalDepartment of Neuropsychiatry, Faculty of Life Sciences, Kumamoto UniversityFaculty of Social Welfare, Kumamoto Gakuen UniversityDepartment of Geriatric Psychiatry, Mitsugumachi ClinicDepartment of Psychiatry, Kumamoto Seimei HospitalDepartment of Frailty Research, Center for Gerontology and Social Science, National Center for Geriatrics and GerontologyDepartment of Psychiatry, Mashiki HospitalDepartment of Neuropsychiatry, Faculty of Life Sciences, Kumamoto UniversityDepartment of Neuropsychiatry, Faculty of Life Sciences, Kumamoto UniversityDepartment of Radiology, Faculty of Medicine, Kindai UniversityDepartment of Psychiatry, Osaka University Graduate School of MedicineDepartment of Neuropsychiatry, Faculty of Life Sciences, Kumamoto UniversityAbstract Background An increase in choroid plexus (CP) volume may be associated with cognitive decline in older individuals without dementia. In this study, we aimed to clarify whether CP volume can serve as an imaging marker of cognitive decline, determine how strongly CP volume is associated with cognitive decline, and explore factors associated with CP volume in older adults. Methods We measured CP volume, brain parenchyma, and cerebrospinal fluid (CSF) spaces associated with disproportionately enlarged subarachnoid space hydrocephalus (DESH), an imaging feature of normal-pressure hydrocephalus, in community-dwelling older adults aged ≥ 65 years without dementia. Results In 1,370 participants, lower Mini-Mental State Examination (MMSE) scores were significantly associated with higher CP volume, even after adjusting for DESH-related CSF space and brain parenchymal volume. CP volume was more strongly associated with MMSE scores than DESH-related CSF space and brain parenchymal volume. History of smoking, white matter hyperintensity, enlarged perivascular spaces, age, body mass index, and diabetes mellitus were also associated with increased CP volume. Conclusions CP volume may be a highly sensitive imaging marker of cognitive decline in community-dwelling older adults without dementia, as it is linked to cognitive decline independently of brain parenchyma and CSF volumes. Our findings emphasize the importance of investigating CP volume increase to maintain cognitive function in older individuals. Accordingly, further longitudinal studies are required.https://doi.org/10.1186/s12987-024-00601-0Choroid plexusCerebrospinal fluidCognitive impairment |
| spellingShingle | Yosuke Hidaka Mamoru Hashimoto Takashi Suehiro Ryuji Fukuhara Tomohisa Ishikawa Naoko Tsunoda Asuka Koyama Kazuki Honda Yusuke Miyagawa Kazuhiro Yoshiura Seiji Yuuki Naoto Kajitani Shuken Boku Kazunari Ishii Manabu Ikeda Minoru Takebayashi Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia: a population-based cross-sectional analysis Fluids and Barriers of the CNS Choroid plexus Cerebrospinal fluid Cognitive impairment |
| title | Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia: a population-based cross-sectional analysis |
| title_full | Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia: a population-based cross-sectional analysis |
| title_fullStr | Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia: a population-based cross-sectional analysis |
| title_full_unstemmed | Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia: a population-based cross-sectional analysis |
| title_short | Association between choroid plexus volume and cognitive function in community-dwelling older adults without dementia: a population-based cross-sectional analysis |
| title_sort | association between choroid plexus volume and cognitive function in community dwelling older adults without dementia a population based cross sectional analysis |
| topic | Choroid plexus Cerebrospinal fluid Cognitive impairment |
| url | https://doi.org/10.1186/s12987-024-00601-0 |
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