Characterisation of airway disease associated with Sjögren disease
Objective Although airway disease associated with Sjögren’s disease (Sjo-AD) is common, it is poorly studied compared with interstitial lung disease (ILD). In this study, we aimed to assess factors associated with Sjo-AD, the characteristics and prognosis of this manifestation.Methods We performed a...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2024-02-01
|
| Series: | RMD Open |
| Online Access: | https://rmdopen.bmj.com/content/10/1/e003866.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849325000967847936 |
|---|---|
| author | Eric Hachulla Xavier Mariette Jacques-Eric Gottenberg Marie-Pierre Debray Philippe Dieude Alain Saraux Olivier Vittecoq Emanuelle Dernis Raphaele Seror Gaetane Nocturne Cindy Marques Veronique Le Guern Claire Larroche Robin Dhote Pierre-Antoine Juge Anne Laure Fauchais Antoine Beurnier Loïc Meudec |
| author_facet | Eric Hachulla Xavier Mariette Jacques-Eric Gottenberg Marie-Pierre Debray Philippe Dieude Alain Saraux Olivier Vittecoq Emanuelle Dernis Raphaele Seror Gaetane Nocturne Cindy Marques Veronique Le Guern Claire Larroche Robin Dhote Pierre-Antoine Juge Anne Laure Fauchais Antoine Beurnier Loïc Meudec |
| author_sort | Eric Hachulla |
| collection | DOAJ |
| description | Objective Although airway disease associated with Sjögren’s disease (Sjo-AD) is common, it is poorly studied compared with interstitial lung disease (ILD). In this study, we aimed to assess factors associated with Sjo-AD, the characteristics and prognosis of this manifestation.Methods We performed a retrospective multicentric study involving nine centres. We included Sjo-AD patients confirmed by at least one clinician and one CT scan report. Clinical and biological data, pulmonary function test (PFT), and CT scans were collected. A single radiologist specialist in thoracic diseases reviewed CT scans. Sjo-AD patients were compared with Sjo controls without pulmonary involvement, randomly selected after matching for age and disease duration.Results We included 31 Sjo-AD and 62 Sjo controls without pulmonary history. Sjo-AD had a higher disease activity (ESSDAI) compared with controls, even when excluding the pulmonary domain of the score (7 vs 3.8, p<0.05), mainly due to the biological activity. Sjo-AD was multilobar (72%) and associated with signs of both bronchiectasis and bronchiolitis (60%). Obstructive lung disease occurred in 32% at the time of Sjo-AD diagnosis. Overall, PFT was stable after 8.7±7 years follow-up but repeated CT scans showed extended lesions in 41% of cases within 6±3.2 years. No patient developed Sjo-ILD. Sjo-AD progression was independent of the global disease activity.Conclusions Sjo-AD preferentially affects Sjo patients with higher biological activity. It is often characterised as a diffuse disease, affecting both proximal and distal airways, with a slow evolution over time and no progression to Sjo-ILD. |
| format | Article |
| id | doaj-art-59e35ec4f8a84b42a7749e1492c2070e |
| institution | Kabale University |
| issn | 2056-5933 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | RMD Open |
| spelling | doaj-art-59e35ec4f8a84b42a7749e1492c2070e2025-08-20T03:48:31ZengBMJ Publishing GroupRMD Open2056-59332024-02-0110110.1136/rmdopen-2023-003866Characterisation of airway disease associated with Sjögren diseaseEric Hachulla0Xavier Mariette1Jacques-Eric Gottenberg2Marie-Pierre Debray3Philippe Dieude4Alain Saraux5Olivier Vittecoq6Emanuelle Dernis7Raphaele Seror8Gaetane Nocturne9Cindy Marques10Veronique Le Guern11Claire Larroche12Robin Dhote13Pierre-Antoine Juge14Anne Laure Fauchais15Antoine Beurnier16Loïc Meudec17CHU Lille, Département de Médecine Interne et Immunologie Clinique, Centre de Référence des Maladies Auto-Immunes et Auto-Inflammatoires Rares du Nord, Nord-Ouest, Méditerranée et Guadeloupe (CeRAINOM), Lille, FranceDepartment of Rheumatology, Université Paris-Saclay, AP-HP-Hôpital Bicêtre, Paris, FranceImmunologie, Immunopathologie et Chimie Thérapeutique, CNRS UPR 3572, IBMC, Strasbourg, FranceDepartment of Radiology, Hôpital Bichat Claude-Bernard, Assistance Publique-Hôpitaux de Paris, Paris, FranceDepartment of Rheumatology, Hôpital Bichat Claude-Bernard, Assistance Publique-Hôpitaux de Paris, Paris, FranceDepartment of Rheumatology, Hopital Cavale Blanche, Brest, FranceDepartment of Rheumatology, CHU Rouen Normandie, Rouen, FranceRheumatology, Le Mans Hospital, Le Mans, France22 Center for Immunology of Viral Infections and Autoimmune Diseases, INSERM UMR 1184, Université Paris Sud, Université Paris-Saclay, Paris, FranceDepartment of Rheumatology, Hôpital Bicêtre, Le Kremlin-Bicetre, FranceDepartment of Rheumatology, Université Paris-Saclay, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, FranceDepartment of Internal Medicine, APHP, Paris, FranceDepartment of Internal Medicine, Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris, Bobigny, FranceDepartment of Internal Medicine, Hopital Avicenne, Bobigny, FranceService de Rhumatologie, Hôpital Bichat-Claude Bernard, APHP, Université Paris Cité, Paris, FranceDepartment of Rheumatology, Centre Hospitalier Universitaire de Limoges, Limoges, FranceDepartment of Functional Explorations, Hôpital Bicetre, Assistance Publique-Hôpitaux de Paris, Le Kremlin-Bicetre, FranceDepartment of Rheumatology, Université Paris-Saclay, Hôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Le Kremlin Bicêtre, FranceObjective Although airway disease associated with Sjögren’s disease (Sjo-AD) is common, it is poorly studied compared with interstitial lung disease (ILD). In this study, we aimed to assess factors associated with Sjo-AD, the characteristics and prognosis of this manifestation.Methods We performed a retrospective multicentric study involving nine centres. We included Sjo-AD patients confirmed by at least one clinician and one CT scan report. Clinical and biological data, pulmonary function test (PFT), and CT scans were collected. A single radiologist specialist in thoracic diseases reviewed CT scans. Sjo-AD patients were compared with Sjo controls without pulmonary involvement, randomly selected after matching for age and disease duration.Results We included 31 Sjo-AD and 62 Sjo controls without pulmonary history. Sjo-AD had a higher disease activity (ESSDAI) compared with controls, even when excluding the pulmonary domain of the score (7 vs 3.8, p<0.05), mainly due to the biological activity. Sjo-AD was multilobar (72%) and associated with signs of both bronchiectasis and bronchiolitis (60%). Obstructive lung disease occurred in 32% at the time of Sjo-AD diagnosis. Overall, PFT was stable after 8.7±7 years follow-up but repeated CT scans showed extended lesions in 41% of cases within 6±3.2 years. No patient developed Sjo-ILD. Sjo-AD progression was independent of the global disease activity.Conclusions Sjo-AD preferentially affects Sjo patients with higher biological activity. It is often characterised as a diffuse disease, affecting both proximal and distal airways, with a slow evolution over time and no progression to Sjo-ILD.https://rmdopen.bmj.com/content/10/1/e003866.full |
| spellingShingle | Eric Hachulla Xavier Mariette Jacques-Eric Gottenberg Marie-Pierre Debray Philippe Dieude Alain Saraux Olivier Vittecoq Emanuelle Dernis Raphaele Seror Gaetane Nocturne Cindy Marques Veronique Le Guern Claire Larroche Robin Dhote Pierre-Antoine Juge Anne Laure Fauchais Antoine Beurnier Loïc Meudec Characterisation of airway disease associated with Sjögren disease RMD Open |
| title | Characterisation of airway disease associated with Sjögren disease |
| title_full | Characterisation of airway disease associated with Sjögren disease |
| title_fullStr | Characterisation of airway disease associated with Sjögren disease |
| title_full_unstemmed | Characterisation of airway disease associated with Sjögren disease |
| title_short | Characterisation of airway disease associated with Sjögren disease |
| title_sort | characterisation of airway disease associated with sjogren disease |
| url | https://rmdopen.bmj.com/content/10/1/e003866.full |
| work_keys_str_mv | AT erichachulla characterisationofairwaydiseaseassociatedwithsjogrendisease AT xaviermariette characterisationofairwaydiseaseassociatedwithsjogrendisease AT jacquesericgottenberg characterisationofairwaydiseaseassociatedwithsjogrendisease AT mariepierredebray characterisationofairwaydiseaseassociatedwithsjogrendisease AT philippedieude characterisationofairwaydiseaseassociatedwithsjogrendisease AT alainsaraux characterisationofairwaydiseaseassociatedwithsjogrendisease AT oliviervittecoq characterisationofairwaydiseaseassociatedwithsjogrendisease AT emanuelledernis characterisationofairwaydiseaseassociatedwithsjogrendisease AT raphaeleseror characterisationofairwaydiseaseassociatedwithsjogrendisease AT gaetanenocturne characterisationofairwaydiseaseassociatedwithsjogrendisease AT cindymarques characterisationofairwaydiseaseassociatedwithsjogrendisease AT veroniqueleguern characterisationofairwaydiseaseassociatedwithsjogrendisease AT clairelarroche characterisationofairwaydiseaseassociatedwithsjogrendisease AT robindhote characterisationofairwaydiseaseassociatedwithsjogrendisease AT pierreantoinejuge characterisationofairwaydiseaseassociatedwithsjogrendisease AT annelaurefauchais characterisationofairwaydiseaseassociatedwithsjogrendisease AT antoinebeurnier characterisationofairwaydiseaseassociatedwithsjogrendisease AT loicmeudec characterisationofairwaydiseaseassociatedwithsjogrendisease |