Case Report: Successful treatment of steroid- and ruxolitinib-refractory gastrointestinal acute graft-versus-Host disease with anti-thymocyte globulin

Case Report: Successful treatment of steroid- and ruxolitinib-refractory gastrointestinal acute graft-versus-Host disease with anti-thymocyte globulin

Acute graft-versus-host disease (aGVHD), particularly with gastrointestinal (GI) involvement, remains a life-threatening complication after allogeneic hematopoietic stem cell transplantation (HSCT). Despite corticosteroids and ruxolitinib as first- and second-line therapies, up to 50% of patients de...

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Bibliographic Details
Main Authors: Lulu Zhang, Fan Wu, Huiping Wang, Zhimin Zhai, Lili Tao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
allogeneic hematopoietic stem cell transplant (HSCT)
acute GVHD
gastrointestinal acute GVHD
anti-thymocyte globulin
graft-versus-host
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1610071/full
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