Maladaptive changes in the homeostasis of AEA-TRPV1/CB1R induces pain-related hyperactivity of nociceptors after spinal cord injury

Maladaptive changes in the homeostasis of AEA-TRPV1/CB1R induces pain-related hyperactivity of nociceptors after spinal cord injury

Abstract Background Neuropathic pain resulting from spinal cord injury (SCI) is associated with persistent hyperactivity of primary nociceptors. Anandamide (AEA) has been reported to modulate neuronal excitability and synaptic transmission through activation of cannabinoid type-1 receptors (CB1Rs) a...

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Bibliographic Details
Main Authors: JiaQi Hu, WenYong Fan, Yue Xu, XiaoFei Li, HaoYang Zhang, Shun Li, Lei Xue
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cell & Bioscience
Subjects:
Spinal cord injury
Anandamide
DRG
Action potentials
Hyperexcitability
Online Access:https://doi.org/10.1186/s13578-025-01345-6
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