Human Disabled-2 regulates thromboxane A2 signaling for efficient hemostasis in thrombocytopenia

Human Disabled-2 regulates thromboxane A2 signaling for efficient hemostasis in thrombocytopenia

Abstract Understanding platelet protein functions facilitates better assessment of platelet disorders. Megakaryocyte lineage-restricted human Disabled-2 knock-in (hDAB2-KI) mice are generated to delineate the functions of hDab2, a regulator of platelet function, in the control of bleeding associated...

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Main Authors: Hui-Ju Tsai, Ya-Fang Chang, Ya-Ju Hsieh, Jiaan-Der Wang, Chih-Ching Wu, Meng-Ying Ho, Ju-Chien Cheng, Ding-Ping Chen, Hsiang-Rui Liao, Ching-Ping Tseng
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54093-5
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