Advancing allergic rhinitis research through phenome-wide association studies: Insights from known genetic loci
Background: Allergic rhinitis (AR) is a common chronic respiratory disease that can lead to the development of various other conditions. Although genetic risk loci associated with AR have been reported, the connections between these loci and AR comorbidities or other diseases remain unclear. Methods...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | World Allergy Organization Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1939455124001467 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841526272500432896 |
|---|---|
| author | Xingling Tan, MD Zhouyouyou Xiao, MB Yao Wen, MD Han Liu, MD Wei Yu, MD |
| author_facet | Xingling Tan, MD Zhouyouyou Xiao, MB Yao Wen, MD Han Liu, MD Wei Yu, MD |
| author_sort | Xingling Tan, MD |
| collection | DOAJ |
| description | Background: Allergic rhinitis (AR) is a common chronic respiratory disease that can lead to the development of various other conditions. Although genetic risk loci associated with AR have been reported, the connections between these loci and AR comorbidities or other diseases remain unclear. Methods: This study conducted a phenome-wide association study (PheWAS) using known AR risk loci to explore the impact of known AR risk variants on a broad spectrum of phenotypes. Subsequently, linkage disequilibrium score regression (LDSC) and bidirectional two-sample mendelian randomization (TSMR) analyses were used to further analyze the genetic correlation and causal relationships between significant and potentially related phenotypes and AR. Results: The PheWAS analysis indicated significant associations between asthma, eczema, nasal polyps, hypothyroidism, and AR risk variants. Additionally, potential associations were observed with ulcerative colitis, psoriasis, chalazion, pernicious anemia, glaucoma, multiple sclerosis, arthritis, prostate cancer, varicose veins of lower extremities, and heart attack. LDSC analysis showed that only asthma, eczema, and nasal polyps have significant positive genetic correlations with AR. Furthermore, TSMR analysis revealed causal relationships between AR and asthma, eczema, and nasal polyps. Conclusion: This study highlights the impact of AR risk loci on a variety of diseases. By revealing new associations and shared genetic pathways, our findings provide valuable insights into the pathophysiology of AR and pave the way for more effective targeted interventions to manage AR and its related diseases. |
| format | Article |
| id | doaj-art-598f32b30f7042b1a614016cc72c5ed7 |
| institution | Kabale University |
| issn | 1939-4551 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | World Allergy Organization Journal |
| spelling | doaj-art-598f32b30f7042b1a614016cc72c5ed72025-01-17T04:49:15ZengElsevierWorld Allergy Organization Journal1939-45512025-01-01181101014Advancing allergic rhinitis research through phenome-wide association studies: Insights from known genetic lociXingling Tan, MD0Zhouyouyou Xiao, MB1Yao Wen, MD2Han Liu, MD3Wei Yu, MD4Institute of Life Science, Chongqing Medical University, Chongqing, ChinaDepartment of Audiology and Speech Rehabilitation, Chongqing Medical University, Chongqing, ChinaInstitute of Life Science, Chongqing Medical University, Chongqing, ChinaInstitute of Life Science, Chongqing Medical University, Chongqing, China; Corresponding author. Institute of Life Science, Chongqing Medical University, No.1 Yixueyuan Road, Yuzhong District, Chongqing, 400016, China.Institute of Life Science, Chongqing Medical University, Chongqing, China; Corresponding author. Institute of Life Science, Chongqing Medical University, No.1 Yixueyuan Road, Yuzhong District, Chongqing, 400016, China.Background: Allergic rhinitis (AR) is a common chronic respiratory disease that can lead to the development of various other conditions. Although genetic risk loci associated with AR have been reported, the connections between these loci and AR comorbidities or other diseases remain unclear. Methods: This study conducted a phenome-wide association study (PheWAS) using known AR risk loci to explore the impact of known AR risk variants on a broad spectrum of phenotypes. Subsequently, linkage disequilibrium score regression (LDSC) and bidirectional two-sample mendelian randomization (TSMR) analyses were used to further analyze the genetic correlation and causal relationships between significant and potentially related phenotypes and AR. Results: The PheWAS analysis indicated significant associations between asthma, eczema, nasal polyps, hypothyroidism, and AR risk variants. Additionally, potential associations were observed with ulcerative colitis, psoriasis, chalazion, pernicious anemia, glaucoma, multiple sclerosis, arthritis, prostate cancer, varicose veins of lower extremities, and heart attack. LDSC analysis showed that only asthma, eczema, and nasal polyps have significant positive genetic correlations with AR. Furthermore, TSMR analysis revealed causal relationships between AR and asthma, eczema, and nasal polyps. Conclusion: This study highlights the impact of AR risk loci on a variety of diseases. By revealing new associations and shared genetic pathways, our findings provide valuable insights into the pathophysiology of AR and pave the way for more effective targeted interventions to manage AR and its related diseases.http://www.sciencedirect.com/science/article/pii/S1939455124001467RhinitisAllergicGenetic predisposition to diseaseAsthmaDermatitisAtopic |
| spellingShingle | Xingling Tan, MD Zhouyouyou Xiao, MB Yao Wen, MD Han Liu, MD Wei Yu, MD Advancing allergic rhinitis research through phenome-wide association studies: Insights from known genetic loci World Allergy Organization Journal Rhinitis Allergic Genetic predisposition to disease Asthma Dermatitis Atopic |
| title | Advancing allergic rhinitis research through phenome-wide association studies: Insights from known genetic loci |
| title_full | Advancing allergic rhinitis research through phenome-wide association studies: Insights from known genetic loci |
| title_fullStr | Advancing allergic rhinitis research through phenome-wide association studies: Insights from known genetic loci |
| title_full_unstemmed | Advancing allergic rhinitis research through phenome-wide association studies: Insights from known genetic loci |
| title_short | Advancing allergic rhinitis research through phenome-wide association studies: Insights from known genetic loci |
| title_sort | advancing allergic rhinitis research through phenome wide association studies insights from known genetic loci |
| topic | Rhinitis Allergic Genetic predisposition to disease Asthma Dermatitis Atopic |
| url | http://www.sciencedirect.com/science/article/pii/S1939455124001467 |
| work_keys_str_mv | AT xinglingtanmd advancingallergicrhinitisresearchthroughphenomewideassociationstudiesinsightsfromknowngeneticloci AT zhouyouyouxiaomb advancingallergicrhinitisresearchthroughphenomewideassociationstudiesinsightsfromknowngeneticloci AT yaowenmd advancingallergicrhinitisresearchthroughphenomewideassociationstudiesinsightsfromknowngeneticloci AT hanliumd advancingallergicrhinitisresearchthroughphenomewideassociationstudiesinsightsfromknowngeneticloci AT weiyumd advancingallergicrhinitisresearchthroughphenomewideassociationstudiesinsightsfromknowngeneticloci |