Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023
Abstract Zoonotic infections (swine-human) caused by influenza A viruses (IAVs) have been reported and linked to close contact between these species. Here, we describe eight human IAV variant infections (6 mild and 2 severe cases, including 1 death) detected in Paraná, Brazil, during 2020–2023. Geno...
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Nature Portfolio
2024-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-024-53815-z |
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| author | Paola Cristina Resende Dennis M. Junqueira Caroline Tochetto Maria Ogrzewalska Fernando C. Motta Jonathan Lopes Luciana Appolinario Larissa Macedo Braulia Caetano Aline Matos Thauane Silva Elisa Cavalcante Pereira Leticia Ferreira Lima Irina Riediger Maria do Carmo Debur Guilherme Nardi Becker Aline Andrade Acácia Maria Lourenço Francisco Nasr Rosana Aparecida Piler Ana Carolina Dalla Vecchia Walquíria Almeida David Brown Rejane Schaefer Marilda M. Siqueira |
| author_facet | Paola Cristina Resende Dennis M. Junqueira Caroline Tochetto Maria Ogrzewalska Fernando C. Motta Jonathan Lopes Luciana Appolinario Larissa Macedo Braulia Caetano Aline Matos Thauane Silva Elisa Cavalcante Pereira Leticia Ferreira Lima Irina Riediger Maria do Carmo Debur Guilherme Nardi Becker Aline Andrade Acácia Maria Lourenço Francisco Nasr Rosana Aparecida Piler Ana Carolina Dalla Vecchia Walquíria Almeida David Brown Rejane Schaefer Marilda M. Siqueira |
| author_sort | Paola Cristina Resende |
| collection | DOAJ |
| description | Abstract Zoonotic infections (swine-human) caused by influenza A viruses (IAVs) have been reported and linked to close contact between these species. Here, we describe eight human IAV variant infections (6 mild and 2 severe cases, including 1 death) detected in Paraná, Brazil, during 2020–2023. Genomes recovered were closely related to Brazilian swIAVs of three major lineages (1 A.3.3.2/pdm09, 1B/human-like, and H3.1990.5), including three H1N1v, two H1N2v, two H3N2v and one H1v. Five H1v were closely related to pdm09 lineage, one H1v (H1N2v) grouped within 1B.2.3 clade, and the two H3v grouped within a clade composed exclusively of Brazilian H3 swIAV (clade H3.1990.5.1). Internal gene segments were closely related to H1N1pdm09 isolated from pigs. IAV variant rarely result in sustained transmission between people, however the potential to develop such ability is of concern and must not be underestimated. This study brings into focus the need for continuous influenza surveillance and timely risk assessment. |
| format | Article |
| id | doaj-art-5971ba0cd49b43758eb387ff09c2b098 |
| institution | Kabale University |
| issn | 2041-1723 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj-art-5971ba0cd49b43758eb387ff09c2b0982025-01-05T12:35:02ZengNature PortfolioNature Communications2041-17232024-12-0115111210.1038/s41467-024-53815-zZoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023Paola Cristina Resende0Dennis M. Junqueira1Caroline Tochetto2Maria Ogrzewalska3Fernando C. Motta4Jonathan Lopes5Luciana Appolinario6Larissa Macedo7Braulia Caetano8Aline Matos9Thauane Silva10Elisa Cavalcante Pereira11Leticia Ferreira Lima12Irina Riediger13Maria do Carmo Debur14Guilherme Nardi Becker15Aline Andrade16Acácia Maria Lourenço Francisco Nasr17Rosana Aparecida Piler18Ana Carolina Dalla Vecchia19Walquíria Almeida20David Brown21Rejane Schaefer22Marilda M. Siqueira23Laboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências (LVRE), Oswaldo Cruz FoundationPrograma de Pós-Graduação em Ciências Biológicas: Bioquímica Toxicológica, Laboratório de Bioinformática e Evolução Viral, Universidade Federal de Santa Maria (UFSM)Embrapa Suínos e AvesLaboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências (LVRE), Oswaldo Cruz FoundationLaboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências (LVRE), Oswaldo Cruz FoundationLaboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências (LVRE), Oswaldo Cruz FoundationLaboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências (LVRE), Oswaldo Cruz FoundationLaboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências (LVRE), Oswaldo Cruz FoundationLaboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências (LVRE), Oswaldo Cruz FoundationLaboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências (LVRE), Oswaldo Cruz FoundationLaboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências (LVRE), Oswaldo Cruz FoundationLaboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências (LVRE), Oswaldo Cruz FoundationLaboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências (LVRE), Oswaldo Cruz FoundationLaboratório Central do Estado do Paraná (LACEN-PR)Laboratório Central do Estado do Paraná (LACEN-PR)Laboratório Central do Estado do Paraná (LACEN-PR)Laboratório Central do Estado do Paraná (LACEN-PR)Secretaria de Estado da Saúde do Paraná, (SESA/PR)Secretaria de Estado da Saúde do Paraná, (SESA/PR)Secretaria de Estado da Saúde do Paraná, (SESA/PR)Secretaria de Vigilância em Saúde e Ambiente (SVSA), Ministério da SaúdeLaboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências (LVRE), Oswaldo Cruz FoundationEmbrapa Suínos e AvesLaboratório de Vírus Respiratórios, Exantemáticos, Enterovírus e Emergências (LVRE), Oswaldo Cruz FoundationAbstract Zoonotic infections (swine-human) caused by influenza A viruses (IAVs) have been reported and linked to close contact between these species. Here, we describe eight human IAV variant infections (6 mild and 2 severe cases, including 1 death) detected in Paraná, Brazil, during 2020–2023. Genomes recovered were closely related to Brazilian swIAVs of three major lineages (1 A.3.3.2/pdm09, 1B/human-like, and H3.1990.5), including three H1N1v, two H1N2v, two H3N2v and one H1v. Five H1v were closely related to pdm09 lineage, one H1v (H1N2v) grouped within 1B.2.3 clade, and the two H3v grouped within a clade composed exclusively of Brazilian H3 swIAV (clade H3.1990.5.1). Internal gene segments were closely related to H1N1pdm09 isolated from pigs. IAV variant rarely result in sustained transmission between people, however the potential to develop such ability is of concern and must not be underestimated. This study brings into focus the need for continuous influenza surveillance and timely risk assessment.https://doi.org/10.1038/s41467-024-53815-z |
| spellingShingle | Paola Cristina Resende Dennis M. Junqueira Caroline Tochetto Maria Ogrzewalska Fernando C. Motta Jonathan Lopes Luciana Appolinario Larissa Macedo Braulia Caetano Aline Matos Thauane Silva Elisa Cavalcante Pereira Leticia Ferreira Lima Irina Riediger Maria do Carmo Debur Guilherme Nardi Becker Aline Andrade Acácia Maria Lourenço Francisco Nasr Rosana Aparecida Piler Ana Carolina Dalla Vecchia Walquíria Almeida David Brown Rejane Schaefer Marilda M. Siqueira Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023 Nature Communications |
| title | Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023 |
| title_full | Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023 |
| title_fullStr | Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023 |
| title_full_unstemmed | Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023 |
| title_short | Zoonotic transmission of novel Influenza A variant viruses detected in Brazil during 2020 to 2023 |
| title_sort | zoonotic transmission of novel influenza a variant viruses detected in brazil during 2020 to 2023 |
| url | https://doi.org/10.1038/s41467-024-53815-z |
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