Utilizing medical thoracoscopy for the diagnosis of B‐cell lymphoma presenting with pleural effusion: A case series
Abstract A third of patients with non‐Hodgkin's lymphoma (NHL) develop pleural effusion during the disease course for various reasons. In most cases, lymphoma‐related pleural effusion is a manifestation of widespread systemic disease, signifying a high tumour burden and therefore, a poorer prog...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | Respirology Case Reports |
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| Online Access: | https://doi.org/10.1002/rcr2.70061 |
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| author | Nai‐Chien Huan Khai Lip Ng Larry Ellee Nyanti Jing Yi Khaw Jiun Hang Lee Nur Husna Mohd Aminudin Dahziela Yunus Nusaibah Azman Maryam Ahmad Sharifuddin Hema Yamini Ramarmuty Kunji Kannan Sivaraman Kannan |
| author_facet | Nai‐Chien Huan Khai Lip Ng Larry Ellee Nyanti Jing Yi Khaw Jiun Hang Lee Nur Husna Mohd Aminudin Dahziela Yunus Nusaibah Azman Maryam Ahmad Sharifuddin Hema Yamini Ramarmuty Kunji Kannan Sivaraman Kannan |
| author_sort | Nai‐Chien Huan |
| collection | DOAJ |
| description | Abstract A third of patients with non‐Hodgkin's lymphoma (NHL) develop pleural effusion during the disease course for various reasons. In most cases, lymphoma‐related pleural effusion is a manifestation of widespread systemic disease, signifying a high tumour burden and therefore, a poorer prognosis. On the other hand, primary pleural lymphomas (PPLs) exhibit exclusive or dominant involvement of serous cavities, without detectable solid tumour masses. PPL is an uncommon disease and is of two types: primary effusion lymphoma (PEL) and diffuse large B‐cell lymphoma associated with chronic inflammation (DLBCL‐CI). PPLs not related to PELs and DLBCL‐CIs are exceedingly rare. Herein, we describe four patients with biopsy proven B‐cell NHL. One had no extra‐pleural involvement at the time of diagnosis, indicating PPL. In all cases, histopathological examination of pleural biopsies obtained via medical thoracoscopy (MT) were crucial in clinching the final diagnosis. Clinicians are alerted to the potential relationship between exudative effusion and NHL as well as the role of MT in the diagnosis of B‐cell NHL. |
| format | Article |
| id | doaj-art-596cb9c0243a4a8e971c4a46f675b5e5 |
| institution | Kabale University |
| issn | 2051-3380 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj-art-596cb9c0243a4a8e971c4a46f675b5e52024-11-26T02:54:34ZengWileyRespirology Case Reports2051-33802024-11-011211n/an/a10.1002/rcr2.70061Utilizing medical thoracoscopy for the diagnosis of B‐cell lymphoma presenting with pleural effusion: A case seriesNai‐Chien Huan0Khai Lip Ng1Larry Ellee Nyanti2Jing Yi Khaw3Jiun Hang Lee4Nur Husna Mohd Aminudin5Dahziela Yunus6Nusaibah Azman7Maryam Ahmad Sharifuddin8Hema Yamini Ramarmuty9Kunji Kannan Sivaraman Kannan10Department of Respiratory Medicine Queen Elizabeth Hospital Kota Kinabalu MalaysiaDepartment of Medicine Melaka Hospital Melaka MalaysiaDepartment of Respiratory Medicine Queen Elizabeth Hospital Kota Kinabalu MalaysiaDepartment of Medicine Melaka Hospital Melaka MalaysiaDepartment of Respiratory Medicine Queen Elizabeth Hospital Kota Kinabalu MalaysiaDepartment of Medicine Melaka Hospital Melaka MalaysiaDepartment of Pathology Queen Elizabeth Hospital Kota Kinabalu MalaysiaDepartment of Pathology Queen Elizabeth Hospital Kota Kinabalu MalaysiaDepartment of Pathology Melaka Hospital Melaka MalaysiaDepartment of Respiratory Medicine Queen Elizabeth Hospital Kota Kinabalu MalaysiaDepartment of Respiratory Medicine Queen Elizabeth Hospital Kota Kinabalu MalaysiaAbstract A third of patients with non‐Hodgkin's lymphoma (NHL) develop pleural effusion during the disease course for various reasons. In most cases, lymphoma‐related pleural effusion is a manifestation of widespread systemic disease, signifying a high tumour burden and therefore, a poorer prognosis. On the other hand, primary pleural lymphomas (PPLs) exhibit exclusive or dominant involvement of serous cavities, without detectable solid tumour masses. PPL is an uncommon disease and is of two types: primary effusion lymphoma (PEL) and diffuse large B‐cell lymphoma associated with chronic inflammation (DLBCL‐CI). PPLs not related to PELs and DLBCL‐CIs are exceedingly rare. Herein, we describe four patients with biopsy proven B‐cell NHL. One had no extra‐pleural involvement at the time of diagnosis, indicating PPL. In all cases, histopathological examination of pleural biopsies obtained via medical thoracoscopy (MT) were crucial in clinching the final diagnosis. Clinicians are alerted to the potential relationship between exudative effusion and NHL as well as the role of MT in the diagnosis of B‐cell NHL.https://doi.org/10.1002/rcr2.70061lymphomamalignant effusionmedical thoracoscopypleural effusion |
| spellingShingle | Nai‐Chien Huan Khai Lip Ng Larry Ellee Nyanti Jing Yi Khaw Jiun Hang Lee Nur Husna Mohd Aminudin Dahziela Yunus Nusaibah Azman Maryam Ahmad Sharifuddin Hema Yamini Ramarmuty Kunji Kannan Sivaraman Kannan Utilizing medical thoracoscopy for the diagnosis of B‐cell lymphoma presenting with pleural effusion: A case series Respirology Case Reports lymphoma malignant effusion medical thoracoscopy pleural effusion |
| title | Utilizing medical thoracoscopy for the diagnosis of B‐cell lymphoma presenting with pleural effusion: A case series |
| title_full | Utilizing medical thoracoscopy for the diagnosis of B‐cell lymphoma presenting with pleural effusion: A case series |
| title_fullStr | Utilizing medical thoracoscopy for the diagnosis of B‐cell lymphoma presenting with pleural effusion: A case series |
| title_full_unstemmed | Utilizing medical thoracoscopy for the diagnosis of B‐cell lymphoma presenting with pleural effusion: A case series |
| title_short | Utilizing medical thoracoscopy for the diagnosis of B‐cell lymphoma presenting with pleural effusion: A case series |
| title_sort | utilizing medical thoracoscopy for the diagnosis of b cell lymphoma presenting with pleural effusion a case series |
| topic | lymphoma malignant effusion medical thoracoscopy pleural effusion |
| url | https://doi.org/10.1002/rcr2.70061 |
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