Biomechanical enhancement in rotator cuff repairs: the impact of innovative nanofiber technology
Background: Rotator cuff repair surgeries often face high failure rates, particularly in cases involving tendon degeneration. Traditional repair techniques and devices frequently fail to adequately restore a healthy native enthesis and strong tendon-bone integration. This study investigates the effi...
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Elsevier
2025-01-01
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| Series: | JSES International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666638324003955 |
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| author | James Johnson, PhD Ben Gadomski, PhD Daniel Regan, DVM, PhD, DACVP Jed Johnson, PhD Brad Nelson, MS, PhD, DVM, DACVS Kirk McGilvray, PhD Kevin Labus, PhD Anthony Romeo, MD Jeremiah Easley, DVM, Dipl, ACVS |
| author_facet | James Johnson, PhD Ben Gadomski, PhD Daniel Regan, DVM, PhD, DACVP Jed Johnson, PhD Brad Nelson, MS, PhD, DVM, DACVS Kirk McGilvray, PhD Kevin Labus, PhD Anthony Romeo, MD Jeremiah Easley, DVM, Dipl, ACVS |
| author_sort | James Johnson, PhD |
| collection | DOAJ |
| description | Background: Rotator cuff repair surgeries often face high failure rates, particularly in cases involving tendon degeneration. Traditional repair techniques and devices frequently fail to adequately restore a healthy native enthesis and strong tendon-bone integration. This study investigates the efficacy of a novel, fully synthetic, bioresorbable nanofiber scaffold in restoring the native enthesis and enhancing the biomechanical properties and overall success of rotator cuff repairs, particularly in the context of chronically degenerated tendons. Methods: This study used an ovine model to simulate chronic tendon degeneration with subsequent rotator cuff transection and repair. All repairs were performed using the standard double-row configuration with suture tape; half of the repairs were augmented with the bioresorbable nanofiber scaffold. Nondestructive biomechanical testing was conducted to assess the strength of the repair constructs, followed by histological analysis of all tendon samples to evaluate tissue regeneration and integration at the repair site. Results: Results demonstrated that the scaffold group achieved significantly improved biomechanical properties (peak force, peak stress, equilibrium force, and equilibrium stress) compared to the suture only group, indicating enhanced repair strength and native enthesis restoration. Scaffold samples exhibited significantly decreased cross-sectional areas (ie, less fibrosis) which were similar to healthy tendons. Histological findings indicated the scaffold did not impede re-establishment of Sharpey-like fibers at the tendon insertion. Conclusion: This study provides compelling evidence that the use of a fully synthetic, bioresorbable nanofiber scaffold in rotator cuff repair significantly improves biomechanical outcomes and enthesis regeneration. These improvements were achieved while retaining close to native tendon thickness. The findings suggest that this scaffold represents a significant advancement in rotator cuff repair technology, offering a promising solution to enhance repair strength and quality of bone-tendon integration, especially in challenging cases of tendon degeneration. |
| format | Article |
| id | doaj-art-595e7438e34044dbb0cf5d028a1728a0 |
| institution | Kabale University |
| issn | 2666-6383 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JSES International |
| spelling | doaj-art-595e7438e34044dbb0cf5d028a1728a02025-01-12T05:26:01ZengElsevierJSES International2666-63832025-01-0191116122Biomechanical enhancement in rotator cuff repairs: the impact of innovative nanofiber technologyJames Johnson, PhD0Ben Gadomski, PhD1Daniel Regan, DVM, PhD, DACVP2Jed Johnson, PhD3Brad Nelson, MS, PhD, DVM, DACVS4Kirk McGilvray, PhD5Kevin Labus, PhD6Anthony Romeo, MD7Jeremiah Easley, DVM, Dipl, ACVS8Orthopedic Bioengineering Research Laboratory, Colorado State University, Fort Collins, CO, USA; Corresponding author: James Johnson, PhD, Orthopedic Bioengineering Research Laboratory, Colorado State University, 300 West Drake Street, Fort Collins, CO 80523, USA.Orthopedic Bioengineering Research Laboratory, Colorado State University, Fort Collins, CO, USAFlint Animal Cancer Center and Department of Microbiology, Immunology, & Pathology, Fort Collins, CO, USAAtreon Orthopedics, Dublin, OH, USAPreclinical Surgical Research Laboratory, Colorado State University, Fort Collins, CO, USA; USA State University, Fort Collins, CO, USAOrthopedic Bioengineering Research Laboratory, Colorado State University, Fort Collins, CO, USAOrthopedic Bioengineering Research Laboratory, Colorado State University, Fort Collins, CO, USARothman Orthopaedic Institute, New York, NY, USAPreclinical Surgical Research Laboratory, Colorado State University, Fort Collins, CO, USA; USA State University, Fort Collins, CO, USABackground: Rotator cuff repair surgeries often face high failure rates, particularly in cases involving tendon degeneration. Traditional repair techniques and devices frequently fail to adequately restore a healthy native enthesis and strong tendon-bone integration. This study investigates the efficacy of a novel, fully synthetic, bioresorbable nanofiber scaffold in restoring the native enthesis and enhancing the biomechanical properties and overall success of rotator cuff repairs, particularly in the context of chronically degenerated tendons. Methods: This study used an ovine model to simulate chronic tendon degeneration with subsequent rotator cuff transection and repair. All repairs were performed using the standard double-row configuration with suture tape; half of the repairs were augmented with the bioresorbable nanofiber scaffold. Nondestructive biomechanical testing was conducted to assess the strength of the repair constructs, followed by histological analysis of all tendon samples to evaluate tissue regeneration and integration at the repair site. Results: Results demonstrated that the scaffold group achieved significantly improved biomechanical properties (peak force, peak stress, equilibrium force, and equilibrium stress) compared to the suture only group, indicating enhanced repair strength and native enthesis restoration. Scaffold samples exhibited significantly decreased cross-sectional areas (ie, less fibrosis) which were similar to healthy tendons. Histological findings indicated the scaffold did not impede re-establishment of Sharpey-like fibers at the tendon insertion. Conclusion: This study provides compelling evidence that the use of a fully synthetic, bioresorbable nanofiber scaffold in rotator cuff repair significantly improves biomechanical outcomes and enthesis regeneration. These improvements were achieved while retaining close to native tendon thickness. The findings suggest that this scaffold represents a significant advancement in rotator cuff repair technology, offering a promising solution to enhance repair strength and quality of bone-tendon integration, especially in challenging cases of tendon degeneration.http://www.sciencedirect.com/science/article/pii/S2666638324003955Basic Science StudyBiomechanics |
| spellingShingle | James Johnson, PhD Ben Gadomski, PhD Daniel Regan, DVM, PhD, DACVP Jed Johnson, PhD Brad Nelson, MS, PhD, DVM, DACVS Kirk McGilvray, PhD Kevin Labus, PhD Anthony Romeo, MD Jeremiah Easley, DVM, Dipl, ACVS Biomechanical enhancement in rotator cuff repairs: the impact of innovative nanofiber technology JSES International Basic Science Study Biomechanics |
| title | Biomechanical enhancement in rotator cuff repairs: the impact of innovative nanofiber technology |
| title_full | Biomechanical enhancement in rotator cuff repairs: the impact of innovative nanofiber technology |
| title_fullStr | Biomechanical enhancement in rotator cuff repairs: the impact of innovative nanofiber technology |
| title_full_unstemmed | Biomechanical enhancement in rotator cuff repairs: the impact of innovative nanofiber technology |
| title_short | Biomechanical enhancement in rotator cuff repairs: the impact of innovative nanofiber technology |
| title_sort | biomechanical enhancement in rotator cuff repairs the impact of innovative nanofiber technology |
| topic | Basic Science Study Biomechanics |
| url | http://www.sciencedirect.com/science/article/pii/S2666638324003955 |
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