CMV IN HEMATOPOIETIC STEM CELL TRANSPLANTATION
Due to its negative impact in the outcome of stem cell transplant (SCT) and solid organ transplant patients (SOT) CMV has been called “the troll of transplantation”. One of the greatest advances in the management of SCT has been the introduction of the preemptive strategy. Since its introduction, th...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2016-06-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | http://www.mjhid.org/index.php/mjhid/article/view/2606 |
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| _version_ | 1846096473665568768 |
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| author | Rafael de la Camara |
| author_facet | Rafael de la Camara |
| author_sort | Rafael de la Camara |
| collection | DOAJ |
| description | Due to its negative impact in the outcome of stem cell transplant (SCT) and solid organ transplant patients (SOT) CMV has been called “the troll of transplantation”. One of the greatest advances in the management of SCT has been the introduction of the preemptive strategy. Since its introduction, the incidence of the viremia, as expected, remains unchanged but there has been a marked decline in the incidence of early CMV disease. But in spite of the advances in prevention of CMV disease, CMV is still today an important cause of morbidity and mortality. Late CMV disease is still occurring in a significant proportion of patients and the so-called indirect effects of CMV are causing significant morbidity and mortality. Fortunately, there have been several advances in the development of new antivirals, adoptive immunotherapy and DNA-CMV vaccines that might transform the management of CMV in the near future. |
| format | Article |
| id | doaj-art-594d1b2e6fca4694adf0bcc4e62b21e0 |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2016-06-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-594d1b2e6fca4694adf0bcc4e62b21e02025-01-02T06:45:25ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062016-06-0180e2016031e201603110.4084/mjhid.2016.0311618CMV IN HEMATOPOIETIC STEM CELL TRANSPLANTATIONRafael de la Camara0> Hospital de la Princesa > C/Diego de León nº 62 > Madrid 28006 > Spain > > JRCAMARA@telefonica.netDue to its negative impact in the outcome of stem cell transplant (SCT) and solid organ transplant patients (SOT) CMV has been called “the troll of transplantation”. One of the greatest advances in the management of SCT has been the introduction of the preemptive strategy. Since its introduction, the incidence of the viremia, as expected, remains unchanged but there has been a marked decline in the incidence of early CMV disease. But in spite of the advances in prevention of CMV disease, CMV is still today an important cause of morbidity and mortality. Late CMV disease is still occurring in a significant proportion of patients and the so-called indirect effects of CMV are causing significant morbidity and mortality. Fortunately, there have been several advances in the development of new antivirals, adoptive immunotherapy and DNA-CMV vaccines that might transform the management of CMV in the near future.http://www.mjhid.org/index.php/mjhid/article/view/2606Hematopoietic Stem Cell TransplantationCytomegalic Infection |
| spellingShingle | Rafael de la Camara CMV IN HEMATOPOIETIC STEM CELL TRANSPLANTATION Mediterranean Journal of Hematology and Infectious Diseases Hematopoietic Stem Cell Transplantation Cytomegalic Infection |
| title | CMV IN HEMATOPOIETIC STEM CELL TRANSPLANTATION |
| title_full | CMV IN HEMATOPOIETIC STEM CELL TRANSPLANTATION |
| title_fullStr | CMV IN HEMATOPOIETIC STEM CELL TRANSPLANTATION |
| title_full_unstemmed | CMV IN HEMATOPOIETIC STEM CELL TRANSPLANTATION |
| title_short | CMV IN HEMATOPOIETIC STEM CELL TRANSPLANTATION |
| title_sort | cmv in hematopoietic stem cell transplantation |
| topic | Hematopoietic Stem Cell Transplantation Cytomegalic Infection |
| url | http://www.mjhid.org/index.php/mjhid/article/view/2606 |
| work_keys_str_mv | AT rafaeldelacamara cmvinhematopoieticstemcelltransplantation |