Risk factors for multivessel coronary lesion in patients with coronary artery disease and primary hypothyroidism
Background. The association of hypothyroidism with ischemic heart disease (CHD) is an aggravating factor of the course for the main cardiovascular pathology. The data available in the modern literature on the effect of hypothyroidism on the factors of the course of coronary heart disease are cont...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Penza State University Publishing House
2024-11-01
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| Series: | Известия высших учебных заведений. Поволжский регион: Медицинские науки |
| Subjects: | |
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| Summary: | Background. The association of hypothyroidism with ischemic heart disease
(CHD) is an aggravating factor of the course for the main cardiovascular pathology. The
data available in the modern literature on the effect of hypothyroidism on the factors of the
course of coronary heart disease are contradictory. The purpose of this study is a comparative
analysis of laboratory and instrumental data taken into account during coronary artery
disease in patients with and without hypothyroidism and the search for possible associations
of thyroid hormone levels with indicators of the state of the coronary bed. Materials
and methods. 240 patients with coronary heart disease were examined. The study group
consisted of 90 patients with coronary heart disease and hypothyroidism, the comparison
group – patients with coronary heart disease without thyroid pathology ‒ 150. A comprehensive
examination of patients, including coronary angiography, was carried out. The frequency
of cases and characteristics of lesions of the coronary bed, possible associations of
thyroid hormones with factors of progression of atherosclerosis of the coronary arteries
were evaluated. Results. The study revealed significant changes in the lipid spectrum, the
severity of myocardial ischemia according to ECG, as well as the frequency of occurrence
of multivessel lesions of the coronary bed in the group of patients with hypothyroidism and
coronary artery disease compared with patients with coronary artery disease without hypothyroidism.
The identified factors had a statistically significant association with thyroid
hormones in the group of patients with coronary heart disease and hypothyroidism. Conclusions.
The presence of hypothyroidism in patients with coronary artery disease, especially
long-term existing, should be considered as an additional factor in the deterioration of the
coronary bed and the course of coronary artery disease. |
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| ISSN: | 2072-3032 |