Increased CSN5 expression enhances the sensitivity to lenalidomide in multiple myeloma cells

Increased CSN5 expression enhances the sensitivity to lenalidomide in multiple myeloma cells

Summary: Lenalidomide (LEN) is commonly used as an effective therapeutic agent for multiple myeloma (MM). However, in some patients, primary resistance to LEN is observed, the mechanisms of which remain poorly understood. In this study, we combined a LEN sensitivity assay with proteomics data from 1...

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Bibliographic Details
Main Authors: Takumi Yamamoto, Arisu Furukawa, Yue Zhou, Nobuaki Kono, Shojiro Kitajima, Hiroto Ohguchi, Yawara Kawano, Shingo Ito, Norie Araki, Sumio Ohtsuki, Takeshi Masuda
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
Molecular biology
Cell biology
Cancer
Proteomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224026245
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