Pediatric venous thromboembolism: incidence and patient profile in a single Brazilian institution
Background: As the diagnosis of Pediatric venous thromboembolism has dramatically increased in recent decades, this study aims to evaluate these patients, determining the incidence and describing their biological and clinical characteristics. Methods: An observational, cross-sectional study was cond...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-11-01
|
| Series: | Hematology, Transfusion and Cell Therapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2531137924003183 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846148458834034688 |
|---|---|
| author | Liana Ariel de Siqueira Lira Jorge David Aivazoglou Carneiro Maria do Carmo Menezes Bezerra Duarte |
| author_facet | Liana Ariel de Siqueira Lira Jorge David Aivazoglou Carneiro Maria do Carmo Menezes Bezerra Duarte |
| author_sort | Liana Ariel de Siqueira Lira |
| collection | DOAJ |
| description | Background: As the diagnosis of Pediatric venous thromboembolism has dramatically increased in recent decades, this study aims to evaluate these patients, determining the incidence and describing their biological and clinical characteristics. Methods: An observational, cross-sectional study was conducted at a Brazilian quaternary hospital between January 2022 and February 2023. Under 18-year-old hospitalized patients with a confirmed diagnosis of venous thromboembolism were included, while those with arterial or chronic thrombosis were excluded. Data on biological and clinical characteristics, diagnosis and treatment were evaluated. A descriptive data analysis was performed and the incidence of hospital-associated thrombosis was calculated. Results: Thirty-nine pediatric patients were evaluated. The incidence of hospital-associated thrombosis was 19.9 cases per 10,000 pediatric hospitalizations. Median age at diagnosis was four months (range: 12 days-17 years). Most of the patients (66.7%) were asymptomatic, with venous thromboembolism being diagnosed incidentally. In all cases, at least one risk factor was identified and in 74.6% of cases four or more factors were present. The principal risk factors were the presence of a central venous catheter (89.7%) and infection (89.7%). Thrombogenic comorbidities, particularly congenital heart disease, were present in 48.7% of patients. Conclusions: The incidence of venous thromboembolism found in the present study was lower than rates reported in developed countries. The principal characteristics of this sample were a greater frequency of central venous catheter and infection as risk factors, and the fact that the cases consisted mainly of newborns and individuals with heart disease. |
| format | Article |
| id | doaj-art-590d639d7b734f7dbcc4a9f8a37b46ce |
| institution | Kabale University |
| issn | 2531-1379 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Hematology, Transfusion and Cell Therapy |
| spelling | doaj-art-590d639d7b734f7dbcc4a9f8a37b46ce2024-12-01T05:07:48ZengElsevierHematology, Transfusion and Cell Therapy2531-13792024-11-0146S227S232Pediatric venous thromboembolism: incidence and patient profile in a single Brazilian institutionLiana Ariel de Siqueira Lira0Jorge David Aivazoglou Carneiro1Maria do Carmo Menezes Bezerra Duarte2Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Corresponding author at: Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Rua dos Coelhos, 300, Boa Vista, CEP: 50070-902 Recife, Pernambuco, Brazil.Instituto da Criança, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (FMUSP), São Paulo, SP, BrazilInstituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, BrazilBackground: As the diagnosis of Pediatric venous thromboembolism has dramatically increased in recent decades, this study aims to evaluate these patients, determining the incidence and describing their biological and clinical characteristics. Methods: An observational, cross-sectional study was conducted at a Brazilian quaternary hospital between January 2022 and February 2023. Under 18-year-old hospitalized patients with a confirmed diagnosis of venous thromboembolism were included, while those with arterial or chronic thrombosis were excluded. Data on biological and clinical characteristics, diagnosis and treatment were evaluated. A descriptive data analysis was performed and the incidence of hospital-associated thrombosis was calculated. Results: Thirty-nine pediatric patients were evaluated. The incidence of hospital-associated thrombosis was 19.9 cases per 10,000 pediatric hospitalizations. Median age at diagnosis was four months (range: 12 days-17 years). Most of the patients (66.7%) were asymptomatic, with venous thromboembolism being diagnosed incidentally. In all cases, at least one risk factor was identified and in 74.6% of cases four or more factors were present. The principal risk factors were the presence of a central venous catheter (89.7%) and infection (89.7%). Thrombogenic comorbidities, particularly congenital heart disease, were present in 48.7% of patients. Conclusions: The incidence of venous thromboembolism found in the present study was lower than rates reported in developed countries. The principal characteristics of this sample were a greater frequency of central venous catheter and infection as risk factors, and the fact that the cases consisted mainly of newborns and individuals with heart disease.http://www.sciencedirect.com/science/article/pii/S2531137924003183ThrombosisVenous thromboembolismChildAdolescent |
| spellingShingle | Liana Ariel de Siqueira Lira Jorge David Aivazoglou Carneiro Maria do Carmo Menezes Bezerra Duarte Pediatric venous thromboembolism: incidence and patient profile in a single Brazilian institution Hematology, Transfusion and Cell Therapy Thrombosis Venous thromboembolism Child Adolescent |
| title | Pediatric venous thromboembolism: incidence and patient profile in a single Brazilian institution |
| title_full | Pediatric venous thromboembolism: incidence and patient profile in a single Brazilian institution |
| title_fullStr | Pediatric venous thromboembolism: incidence and patient profile in a single Brazilian institution |
| title_full_unstemmed | Pediatric venous thromboembolism: incidence and patient profile in a single Brazilian institution |
| title_short | Pediatric venous thromboembolism: incidence and patient profile in a single Brazilian institution |
| title_sort | pediatric venous thromboembolism incidence and patient profile in a single brazilian institution |
| topic | Thrombosis Venous thromboembolism Child Adolescent |
| url | http://www.sciencedirect.com/science/article/pii/S2531137924003183 |
| work_keys_str_mv | AT lianaarieldesiqueiralira pediatricvenousthromboembolismincidenceandpatientprofileinasinglebrazilianinstitution AT jorgedavidaivazogloucarneiro pediatricvenousthromboembolismincidenceandpatientprofileinasinglebrazilianinstitution AT mariadocarmomenezesbezerraduarte pediatricvenousthromboembolismincidenceandpatientprofileinasinglebrazilianinstitution |