Oxidant-Antioxidant Balance during On-Pump Coronary Artery Bypass Grafting
Backround. The aim of this study was to evaluate the changes in perioperative oxidant-antioxidant balance in ONCABG. Methods. Twenty-three patients were included in this study. Serum total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) values were assessed pre...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/263058 |
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| author | Umit Mentese Orhan Veli Dogan Ibrahim Turan Sefer Usta Emre Dogan Seda Oztas Mentese Selim Demir Tanil Ozer Ahmet Cagri Aykan Ahmet Alver |
| author_facet | Umit Mentese Orhan Veli Dogan Ibrahim Turan Sefer Usta Emre Dogan Seda Oztas Mentese Selim Demir Tanil Ozer Ahmet Cagri Aykan Ahmet Alver |
| author_sort | Umit Mentese |
| collection | DOAJ |
| description | Backround. The aim of this study was to evaluate the changes in perioperative oxidant-antioxidant balance in ONCABG. Methods. Twenty-three patients were included in this study. Serum total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) values were assessed preoperatively, at 20 minutes after aortic clamping and at 30 minutes, 6 hours, and 48 hours after declamping (reperfusion). The patients were divided into 2 groups according to the median aortic cross clamping (XC) time: group 1 (XC time < 42 minutes) and group 2 (XC time ≥ 42 minutes). Results. TOS and OSI values of whole patients at 30 minutes after reperfusion were higher than preoperative values (P=0.045, P=0.015), while perioperative TAS levels of the patients were similar to the preoperative levels (P=0.173). XC time was correlated with TOS levels at 30 minutes after reperfusion (r=0.43, P=0.041). In group 2, TOS and OSI values at 30 minutes after reperfusion were higher than preoperative values (P=0.023, P=0.048), whereas a significant difference was not found in group 1 (P=0.601, P=0.327). Conclusions. Oxidative imbalance and increase in TOS at reperfusion in ONCABG may be associated with XC time. |
| format | Article |
| id | doaj-art-5906cc69bd134b249fdf0655f7687be1 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-5906cc69bd134b249fdf0655f7687be12025-02-03T05:53:02ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/263058263058Oxidant-Antioxidant Balance during On-Pump Coronary Artery Bypass GraftingUmit Mentese0Orhan Veli Dogan1Ibrahim Turan2Sefer Usta3Emre Dogan4Seda Oztas Mentese5Selim Demir6Tanil Ozer7Ahmet Cagri Aykan8Ahmet Alver9Department of Cardiovascular Surgery, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital, 61040 Trabzon, TurkeyDepartment of Cardiovascular Surgery, Faculty of Medicine, Sakarya University, 54180 Sakarya, TurkeyDepartment of Genetic and Bioengineering, Faculty of Engineering and Natural Sciences, Gumushane University, 29100 Gumushane, TurkeyDepartment of Cardiovascular Surgery, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital, 61040 Trabzon, TurkeyDepartment of Cardiovascular Surgery, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital, 61040 Trabzon, TurkeyDepartment of Emergency Medicine, Kanuni Training and Research Hospital, 61290 Trabzon, TurkeyDepartment of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, TurkeyDepartment of Cardiovascular Surgery, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital, 61040 Trabzon, TurkeyDepartment of Cardiology, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital, 61040 Trabzon, TurkeyDepartment of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, TurkeyBackround. The aim of this study was to evaluate the changes in perioperative oxidant-antioxidant balance in ONCABG. Methods. Twenty-three patients were included in this study. Serum total oxidant status (TOS), total antioxidant status (TAS), and oxidative stress index (OSI) values were assessed preoperatively, at 20 minutes after aortic clamping and at 30 minutes, 6 hours, and 48 hours after declamping (reperfusion). The patients were divided into 2 groups according to the median aortic cross clamping (XC) time: group 1 (XC time < 42 minutes) and group 2 (XC time ≥ 42 minutes). Results. TOS and OSI values of whole patients at 30 minutes after reperfusion were higher than preoperative values (P=0.045, P=0.015), while perioperative TAS levels of the patients were similar to the preoperative levels (P=0.173). XC time was correlated with TOS levels at 30 minutes after reperfusion (r=0.43, P=0.041). In group 2, TOS and OSI values at 30 minutes after reperfusion were higher than preoperative values (P=0.023, P=0.048), whereas a significant difference was not found in group 1 (P=0.601, P=0.327). Conclusions. Oxidative imbalance and increase in TOS at reperfusion in ONCABG may be associated with XC time.http://dx.doi.org/10.1155/2014/263058 |
| spellingShingle | Umit Mentese Orhan Veli Dogan Ibrahim Turan Sefer Usta Emre Dogan Seda Oztas Mentese Selim Demir Tanil Ozer Ahmet Cagri Aykan Ahmet Alver Oxidant-Antioxidant Balance during On-Pump Coronary Artery Bypass Grafting The Scientific World Journal |
| title | Oxidant-Antioxidant Balance during On-Pump Coronary Artery Bypass Grafting |
| title_full | Oxidant-Antioxidant Balance during On-Pump Coronary Artery Bypass Grafting |
| title_fullStr | Oxidant-Antioxidant Balance during On-Pump Coronary Artery Bypass Grafting |
| title_full_unstemmed | Oxidant-Antioxidant Balance during On-Pump Coronary Artery Bypass Grafting |
| title_short | Oxidant-Antioxidant Balance during On-Pump Coronary Artery Bypass Grafting |
| title_sort | oxidant antioxidant balance during on pump coronary artery bypass grafting |
| url | http://dx.doi.org/10.1155/2014/263058 |
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