Practical management of oligometastatic gastric cancer
Gastric cancer is one of the types of cancer with a high prevalence of morbidity. The frequency of esophagogastric junction cancer, 5-year survival rates, perioperative adjuvant therapy, and standard chemotherapeutic regimens for gastric cancer vary between Asian countries and the West. Although oli...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | ESMO Gastrointestinal Oncology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949819824000694 |
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| author | Y. Narita K. Muro D. Takahari |
| author_facet | Y. Narita K. Muro D. Takahari |
| author_sort | Y. Narita |
| collection | DOAJ |
| description | Gastric cancer is one of the types of cancer with a high prevalence of morbidity. The frequency of esophagogastric junction cancer, 5-year survival rates, perioperative adjuvant therapy, and standard chemotherapeutic regimens for gastric cancer vary between Asian countries and the West. Although oligometastasis is considered an intermediate state between localized and systemic disease, no standardized definition regarding metastatic organ sites or international consensus in gastric cancer exists. Both local treatment, such as radical surgery and radiotherapy, and systemic chemotherapy can be employed for treating patients with gastric cancer with oligometastatic disease. Recently, evidence for oligometastatic gastric cancer has been accumulated, including findings from several clinical trials conducted in Asian and Western countries, focusing on both organ-specific and non-organ-specific oligometastatic gastric cancer. Here, we review the latest findings on oligometastasis in gastric cancer, including variations in treatment strategies between Western and Asian countries. Further investigation is needed to determine the most favorable practical management strategies for patients with metachronous oligometastasis in gastric cancer, including the use of molecular-targeted agents and immune checkpoint inhibitors. The results of ongoing trials may shed light on the optimal treatment approaches for oligometastatic disease. |
| format | Article |
| id | doaj-art-58e9e25a5cea42e8925655158cebb5a8 |
| institution | Kabale University |
| issn | 2949-8198 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | ESMO Gastrointestinal Oncology |
| spelling | doaj-art-58e9e25a5cea42e8925655158cebb5a82024-12-17T05:02:28ZengElsevierESMO Gastrointestinal Oncology2949-81982024-12-016100108Practical management of oligometastatic gastric cancerY. Narita0K. Muro1D. Takahari2Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, JapanDepartment of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, JapanDepartment of Medical Oncology, Graduate School of Medicine, Gunma University, Maebashi, Japan; Correspondence to: Prof. Daisuke Takahari, Department of Medical Oncology, Graduate School of Medicine, Gunma University, Maebashi, 371-8511, Japan. Tel: +81-27-220-7927; Fax: +81-27-220-8609Gastric cancer is one of the types of cancer with a high prevalence of morbidity. The frequency of esophagogastric junction cancer, 5-year survival rates, perioperative adjuvant therapy, and standard chemotherapeutic regimens for gastric cancer vary between Asian countries and the West. Although oligometastasis is considered an intermediate state between localized and systemic disease, no standardized definition regarding metastatic organ sites or international consensus in gastric cancer exists. Both local treatment, such as radical surgery and radiotherapy, and systemic chemotherapy can be employed for treating patients with gastric cancer with oligometastatic disease. Recently, evidence for oligometastatic gastric cancer has been accumulated, including findings from several clinical trials conducted in Asian and Western countries, focusing on both organ-specific and non-organ-specific oligometastatic gastric cancer. Here, we review the latest findings on oligometastasis in gastric cancer, including variations in treatment strategies between Western and Asian countries. Further investigation is needed to determine the most favorable practical management strategies for patients with metachronous oligometastasis in gastric cancer, including the use of molecular-targeted agents and immune checkpoint inhibitors. The results of ongoing trials may shed light on the optimal treatment approaches for oligometastatic disease.http://www.sciencedirect.com/science/article/pii/S2949819824000694chemotherapygastric canceroligometastasistreatment strategies |
| spellingShingle | Y. Narita K. Muro D. Takahari Practical management of oligometastatic gastric cancer ESMO Gastrointestinal Oncology chemotherapy gastric cancer oligometastasis treatment strategies |
| title | Practical management of oligometastatic gastric cancer |
| title_full | Practical management of oligometastatic gastric cancer |
| title_fullStr | Practical management of oligometastatic gastric cancer |
| title_full_unstemmed | Practical management of oligometastatic gastric cancer |
| title_short | Practical management of oligometastatic gastric cancer |
| title_sort | practical management of oligometastatic gastric cancer |
| topic | chemotherapy gastric cancer oligometastasis treatment strategies |
| url | http://www.sciencedirect.com/science/article/pii/S2949819824000694 |
| work_keys_str_mv | AT ynarita practicalmanagementofoligometastaticgastriccancer AT kmuro practicalmanagementofoligometastaticgastriccancer AT dtakahari practicalmanagementofoligometastaticgastriccancer |