Functional anatomy and topographical organization of the frontotemporal arcuate fasciculus
Abstract Traditionally, the frontotemporal arcuate fasciculus (AF) is viewed as a single entity in anatomo-clinical models. However, it is unclear if distinct cortical origin and termination patterns within this bundle correspond to specific language functions. We use track-weighted dynamic function...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-12-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-024-07274-3 |
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| _version_ | 1846112259530555392 |
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| author | Gianpaolo Antonio Basile Victor Nozais Angelo Quartarone Andreina Giustiniani Augusto Ielo Antonio Cerasa Demetrio Milardi Majd Abdallah Michel Thiebaut de Schotten Stephanie J. Forkel Alberto Cacciola |
| author_facet | Gianpaolo Antonio Basile Victor Nozais Angelo Quartarone Andreina Giustiniani Augusto Ielo Antonio Cerasa Demetrio Milardi Majd Abdallah Michel Thiebaut de Schotten Stephanie J. Forkel Alberto Cacciola |
| author_sort | Gianpaolo Antonio Basile |
| collection | DOAJ |
| description | Abstract Traditionally, the frontotemporal arcuate fasciculus (AF) is viewed as a single entity in anatomo-clinical models. However, it is unclear if distinct cortical origin and termination patterns within this bundle correspond to specific language functions. We use track-weighted dynamic functional connectivity, a hybrid imaging technique, to study the AF structure and function in two distinct datasets of healthy subjects. Here we show that the AF can be subdivided based on dynamic changes in functional connectivity at the streamline endpoints. An unsupervised parcellation algorithm reveals spatially segregated subunits, which are then functionally quantified through meta-analysis. This approach identifies three distinct clusters within the AF - ventral, middle, and dorsal frontotemporal AF - each linked to different frontal and temporal termination regions and likely involved in various language production and comprehension aspects. Our findings may have relevant implications for the understanding of the functional anatomy of the AF as well as its contribution to linguistic and non-linguistic functions. |
| format | Article |
| id | doaj-art-58e7ff532e374aeba88b2e5b2b8ddd45 |
| institution | Kabale University |
| issn | 2399-3642 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj-art-58e7ff532e374aeba88b2e5b2b8ddd452024-12-22T12:41:51ZengNature PortfolioCommunications Biology2399-36422024-12-017111210.1038/s42003-024-07274-3Functional anatomy and topographical organization of the frontotemporal arcuate fasciculusGianpaolo Antonio Basile0Victor Nozais1Angelo Quartarone2Andreina Giustiniani3Augusto Ielo4Antonio Cerasa5Demetrio Milardi6Majd Abdallah7Michel Thiebaut de Schotten8Stephanie J. Forkel9Alberto Cacciola10Brain Mapping Lab, Department of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of MessinaGroupe d’Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives-UMR 5293, CNRS, CEA, University of BordeauxIRCCS Centro Neurolesi “Bonino Pulejo”IRCCS Centro Neurolesi “Bonino Pulejo”IRCCS Centro Neurolesi “Bonino Pulejo”Institute of Bioimaging and Complex Biological Systems (IBSBC CNR)Brain Mapping Lab, Department of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of MessinaBordeaux Bioinformatics Center (CBiB), IBGC, CNRS, University of BordeauxGroupe d’Imagerie Neurofonctionnelle, Institut des Maladies Neurodégénératives-UMR 5293, CNRS, CEA, University of BordeauxBrain Connectivity and Behaviour Laboratory, Sorbonne UniversitiesBrain Mapping Lab, Department of Biomedical, Dental Sciences and Morphological and Functional Imaging, University of MessinaAbstract Traditionally, the frontotemporal arcuate fasciculus (AF) is viewed as a single entity in anatomo-clinical models. However, it is unclear if distinct cortical origin and termination patterns within this bundle correspond to specific language functions. We use track-weighted dynamic functional connectivity, a hybrid imaging technique, to study the AF structure and function in two distinct datasets of healthy subjects. Here we show that the AF can be subdivided based on dynamic changes in functional connectivity at the streamline endpoints. An unsupervised parcellation algorithm reveals spatially segregated subunits, which are then functionally quantified through meta-analysis. This approach identifies three distinct clusters within the AF - ventral, middle, and dorsal frontotemporal AF - each linked to different frontal and temporal termination regions and likely involved in various language production and comprehension aspects. Our findings may have relevant implications for the understanding of the functional anatomy of the AF as well as its contribution to linguistic and non-linguistic functions.https://doi.org/10.1038/s42003-024-07274-3 |
| spellingShingle | Gianpaolo Antonio Basile Victor Nozais Angelo Quartarone Andreina Giustiniani Augusto Ielo Antonio Cerasa Demetrio Milardi Majd Abdallah Michel Thiebaut de Schotten Stephanie J. Forkel Alberto Cacciola Functional anatomy and topographical organization of the frontotemporal arcuate fasciculus Communications Biology |
| title | Functional anatomy and topographical organization of the frontotemporal arcuate fasciculus |
| title_full | Functional anatomy and topographical organization of the frontotemporal arcuate fasciculus |
| title_fullStr | Functional anatomy and topographical organization of the frontotemporal arcuate fasciculus |
| title_full_unstemmed | Functional anatomy and topographical organization of the frontotemporal arcuate fasciculus |
| title_short | Functional anatomy and topographical organization of the frontotemporal arcuate fasciculus |
| title_sort | functional anatomy and topographical organization of the frontotemporal arcuate fasciculus |
| url | https://doi.org/10.1038/s42003-024-07274-3 |
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