HEMATOLOGICAL ABNORMALITIES IN HIV INFECTED INDUVIDUALS IN CORRELATION TO CD4 COUNTS AND ART STATUS.
ABSTRACT BACKGROUND: HIV is now pandemic in India and other countries and is in its exponential phase. This infection though associated with many opportunistic infections and neoplasm, it further complicates with a marked hematological abnormalities. This study aims to determine the magnitude &...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2014-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1776 |
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| Summary: | ABSTRACT
BACKGROUND: HIV is now pandemic in India and other countries and is in its exponential phase. This infection though associated with many opportunistic infections and neoplasm, it further complicates with a marked hematological abnormalities. This study aims to determine the magnitude & severity of hematological abnormalities in HIV infected individuals and also to analyze these abnormalities in correlation with the CD4 counts. We also attempted to compare these hematological abnormalities in patients on ART and those not on ART.
METHODS: The study was conducted for a period of 30 days, on 120 HIV positive cases including both, patients on ART & not on ART. Controls with similar age & sex distribution was set up. The blood samples were collected and processed on automated cell counter & coagulometer. The parameters were analyzed with respect to CD4 count & ART status.
RESULTS: Among the total of 120 HIV cases 77% had anemia, 21% had leucopenia and 5% had thrombocytopenia. The magnitude and severity of Anemia, Leucopenia, Thrombocytopenia and other parameters was found to be more in patients not on ART , when compared to patients on ART. Similarly, the magnitude and severity of most of hematological abnormalities were inversely proportional to the CD4 count in non ART cases but not with cases on ART.
CONCLUSION: The basic hematological parameters can be used as a prospective screening test to assess the severity & progression of HIV infection when CD4 count is not available. These parameters can be used to assess the response to Anti Retroviral treatment. Therefore, these basic hematological investigations readily available at all centers are of great use while treating HIV infected patients.
Key words: Anemia, Leucopenia, Thrombocytopenia, HIV, CD4 Count, ART. |
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| ISSN: | 2035-3006 |