Activation of MSK-1 exacerbates neuropathic pain through histone H3 phosphorylation in the rats’ dorsal root ganglia and spinal dorsal horn

Activation of MSK-1 exacerbates neuropathic pain through histone H3 phosphorylation in the rats’ dorsal root ganglia and spinal dorsal horn

The exact mechanism underlies the development of neuropathic pain is not yet completely understood. Mitogen and stress-activated kinase 1 (MSK-1) is an important downstream kinase of the mitogen-activated protein kinase (MAPK). It has been extensively studied in the central nervous system, but wheth...

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Bibliographic Details
Main Authors: Li Wang, Yan Gao, Yiming Qiao, Xueli Wang, Zongyi Liang, Ji-Tian Xu, Liren Li
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Brain Research Bulletin
Subjects:
Neuropathic pain
MSK-1
DRG
Spinal cord
P-H3S10
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923024002697
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