Asbestos Induces Reduction of Tumor Immunity
Asbestos-related cancers such as malignant mesothelioma and lung cancer are an important issue in the world. There are many conflicts concerning economical considerations and medical evidence for these cancers and much confusion regarding details of the pathological mechanisms of asbestos-induced ca...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/481439 |
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| _version_ | 1841524860388376576 |
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| author | Naoko Kumagai-Takei Megumi Maeda Ying Chen Hidenori Matsuzaki Suni Lee Yasumitsu Nishimura Junichi Hiratsuka Takemi Otsuki |
| author_facet | Naoko Kumagai-Takei Megumi Maeda Ying Chen Hidenori Matsuzaki Suni Lee Yasumitsu Nishimura Junichi Hiratsuka Takemi Otsuki |
| author_sort | Naoko Kumagai-Takei |
| collection | DOAJ |
| description | Asbestos-related cancers such as malignant mesothelioma and lung cancer are an important issue in the world. There are many conflicts concerning economical considerations and medical evidence for these cancers and much confusion regarding details of the pathological mechanisms of asbestos-induced cancers. For example, there is uncertainty concerning the degree of danger of the iron-absent chrysotile compared with iron-containing crocidolite and amosite. However, regarding bad prognosis of mesothelioma, medical approaches to ensure the recognition of the biological effects of asbestos and the pathological mechanisms of asbestos-induced carcinogenesis, as well as clinical trials to detect the early stage of mesothelioma, should result in better preventions and the cure of these malignancies. We have been investigating the immunological effects of asbestos in relation to the reduction of tumor immunity. In this paper, cellular and molecular approaches to clarify the immunological effects of asbestos are described, and all the findings indicate that the reduction of tumor immunity is caused by asbestos exposure and involvement in asbestos-induced cancers. These investigations may not only allow the clear recognition of the biological effects of asbestos, but also present a novel procedure for early detection of previous asbestos exposure and the presence of mesothelioma as well as the chemoprevention of asbestos-related cancers. |
| format | Article |
| id | doaj-art-58a07a9cc929487eaa31a30246f6aefc |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-58a07a9cc929487eaa31a30246f6aefc2025-02-03T05:47:17ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/481439481439Asbestos Induces Reduction of Tumor ImmunityNaoko Kumagai-Takei0Megumi Maeda1Ying Chen2Hidenori Matsuzaki3Suni Lee4Yasumitsu Nishimura5Junichi Hiratsuka6Takemi Otsuki7Department of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, JapanDepartment of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, JapanDepartment of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, JapanDepartment of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, JapanDepartment of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, JapanDepartment of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, JapanDepartment of Radiation Oncology, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, JapanDepartment of Hygiene, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, JapanAsbestos-related cancers such as malignant mesothelioma and lung cancer are an important issue in the world. There are many conflicts concerning economical considerations and medical evidence for these cancers and much confusion regarding details of the pathological mechanisms of asbestos-induced cancers. For example, there is uncertainty concerning the degree of danger of the iron-absent chrysotile compared with iron-containing crocidolite and amosite. However, regarding bad prognosis of mesothelioma, medical approaches to ensure the recognition of the biological effects of asbestos and the pathological mechanisms of asbestos-induced carcinogenesis, as well as clinical trials to detect the early stage of mesothelioma, should result in better preventions and the cure of these malignancies. We have been investigating the immunological effects of asbestos in relation to the reduction of tumor immunity. In this paper, cellular and molecular approaches to clarify the immunological effects of asbestos are described, and all the findings indicate that the reduction of tumor immunity is caused by asbestos exposure and involvement in asbestos-induced cancers. These investigations may not only allow the clear recognition of the biological effects of asbestos, but also present a novel procedure for early detection of previous asbestos exposure and the presence of mesothelioma as well as the chemoprevention of asbestos-related cancers.http://dx.doi.org/10.1155/2011/481439 |
| spellingShingle | Naoko Kumagai-Takei Megumi Maeda Ying Chen Hidenori Matsuzaki Suni Lee Yasumitsu Nishimura Junichi Hiratsuka Takemi Otsuki Asbestos Induces Reduction of Tumor Immunity Clinical and Developmental Immunology |
| title | Asbestos Induces Reduction of Tumor Immunity |
| title_full | Asbestos Induces Reduction of Tumor Immunity |
| title_fullStr | Asbestos Induces Reduction of Tumor Immunity |
| title_full_unstemmed | Asbestos Induces Reduction of Tumor Immunity |
| title_short | Asbestos Induces Reduction of Tumor Immunity |
| title_sort | asbestos induces reduction of tumor immunity |
| url | http://dx.doi.org/10.1155/2011/481439 |
| work_keys_str_mv | AT naokokumagaitakei asbestosinducesreductionoftumorimmunity AT megumimaeda asbestosinducesreductionoftumorimmunity AT yingchen asbestosinducesreductionoftumorimmunity AT hidenorimatsuzaki asbestosinducesreductionoftumorimmunity AT sunilee asbestosinducesreductionoftumorimmunity AT yasumitsunishimura asbestosinducesreductionoftumorimmunity AT junichihiratsuka asbestosinducesreductionoftumorimmunity AT takemiotsuki asbestosinducesreductionoftumorimmunity |