Electrical Acupuncture Efficacy on Inflammatory Pain
Objective:To explore electrical acupuncture (EA) therapy effects on complete freund's adjuvant (CFA) induced inflammatory pain model rats.Methods:A total of 30 SD male rats were randomly divided into normal saline+Sham Electroacupuncture (NS+SE) group, CFA+Sham EA (CFA+SE) group and CFA+Electro...
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Editorial Office of Rehabilitation Medicine
2018-06-01
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| Series: | 康复学报 |
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| Online Access: | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2018.03032 |
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| author | Minghong SUI Jingjing LI Yun XIANG Guojian SHU Dongmei JIN Tiebin YAN |
| author_facet | Minghong SUI Jingjing LI Yun XIANG Guojian SHU Dongmei JIN Tiebin YAN |
| author_sort | Minghong SUI |
| collection | DOAJ |
| description | Objective:To explore electrical acupuncture (EA) therapy effects on complete freund's adjuvant (CFA) induced inflammatory pain model rats.Methods:A total of 30 SD male rats were randomly divided into normal saline+Sham Electroacupuncture (NS+SE) group, CFA+Sham EA (CFA+SE) group and CFA+Electroacupuncture (CFA+EA) group, with 10 rats in each group. Mechanical and thermal allodynia were assessed before and after EA treatment at Day 4 after CFA injection. Dialysate of the rats was collected from the right tibialis anterior muscle by microdialysis at Day 5 from 1.5 hours before the treatment until 1.5 hours after treatment. Adenosine concentration in the dialysate was analyzed by HPLC.Results:At Day 4 after injection of paclitaxel, EA treatment can obviously increase the pain threshold of CFA-induced inflammatory pain rat model. The mechanical allodynia showed that the VonFrey result of the CFA+EA group was significantly decreased (<italic>P</italic><0.05) after treatment, and the PWL results also significantly prolonged (<italic>P</italic><0.05) compared with the NS+SE group and the CFA+SE group.Conclusion:EA can increase rats pain threshold of CFA-induced inflammatory pain, and alleviate inflammatory pain. The alleviate of inflammatory pain might through adenosine increasment in the local tissue fluid around the acupoints. |
| format | Article |
| id | doaj-art-5878a819c78b4acdb1ffce77b129e841 |
| institution | Kabale University |
| issn | 2096-0328 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Editorial Office of Rehabilitation Medicine |
| record_format | Article |
| series | 康复学报 |
| spelling | doaj-art-5878a819c78b4acdb1ffce77b129e8412025-01-14T10:05:05ZengEditorial Office of Rehabilitation Medicine康复学报2096-03282018-06-01283236,4123127409Electrical Acupuncture Efficacy on Inflammatory PainMinghong SUIJingjing LIYun XIANGGuojian SHUDongmei JINTiebin YANObjective:To explore electrical acupuncture (EA) therapy effects on complete freund's adjuvant (CFA) induced inflammatory pain model rats.Methods:A total of 30 SD male rats were randomly divided into normal saline+Sham Electroacupuncture (NS+SE) group, CFA+Sham EA (CFA+SE) group and CFA+Electroacupuncture (CFA+EA) group, with 10 rats in each group. Mechanical and thermal allodynia were assessed before and after EA treatment at Day 4 after CFA injection. Dialysate of the rats was collected from the right tibialis anterior muscle by microdialysis at Day 5 from 1.5 hours before the treatment until 1.5 hours after treatment. Adenosine concentration in the dialysate was analyzed by HPLC.Results:At Day 4 after injection of paclitaxel, EA treatment can obviously increase the pain threshold of CFA-induced inflammatory pain rat model. The mechanical allodynia showed that the VonFrey result of the CFA+EA group was significantly decreased (<italic>P</italic><0.05) after treatment, and the PWL results also significantly prolonged (<italic>P</italic><0.05) compared with the NS+SE group and the CFA+SE group.Conclusion:EA can increase rats pain threshold of CFA-induced inflammatory pain, and alleviate inflammatory pain. The alleviate of inflammatory pain might through adenosine increasment in the local tissue fluid around the acupoints.http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2018.03032inflammatory painmechanical painthermal painelectrical acupuncturecomplete freund's adjuvantadenosine |
| spellingShingle | Minghong SUI Jingjing LI Yun XIANG Guojian SHU Dongmei JIN Tiebin YAN Electrical Acupuncture Efficacy on Inflammatory Pain 康复学报 inflammatory pain mechanical pain thermal pain electrical acupuncture complete freund's adjuvant adenosine |
| title | Electrical Acupuncture Efficacy on Inflammatory Pain |
| title_full | Electrical Acupuncture Efficacy on Inflammatory Pain |
| title_fullStr | Electrical Acupuncture Efficacy on Inflammatory Pain |
| title_full_unstemmed | Electrical Acupuncture Efficacy on Inflammatory Pain |
| title_short | Electrical Acupuncture Efficacy on Inflammatory Pain |
| title_sort | electrical acupuncture efficacy on inflammatory pain |
| topic | inflammatory pain mechanical pain thermal pain electrical acupuncture complete freund's adjuvant adenosine |
| url | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2018.03032 |
| work_keys_str_mv | AT minghongsui electricalacupunctureefficacyoninflammatorypain AT jingjingli electricalacupunctureefficacyoninflammatorypain AT yunxiang electricalacupunctureefficacyoninflammatorypain AT guojianshu electricalacupunctureefficacyoninflammatorypain AT dongmeijin electricalacupunctureefficacyoninflammatorypain AT tiebinyan electricalacupunctureefficacyoninflammatorypain |