Population pharmacokinetics of rilpivirine following oral administration and long-acting intramuscular injection in real-world people with HIV

Population pharmacokinetics of rilpivirine following oral administration and long-acting intramuscular injection in real-world people with HIV

BackgroundThe pharmacokinetics of long-acting rilpivirine has mostly been studied in clinical trials, which do not fully address the uncertainties that arise in routine clinical situations.Aims and methodsOur population analysis aims to establish percentile curves for rilpivirine concentrations in p...

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Main Authors: Paul Thoueille, Susana Alves Saldanha, Fabian Schaller, Eva Choong, François Veuve, Aline Munting, Matthias Cavassini, Dominique Braun, Huldrych F. Günthard, Jessy J. Duran Ramirez, Bernard Surial, Hansjakob Furrer, Andri Rauch, Pilar Ustero, Alexandra Calmy, Marcel Stöckle, Caroline Di Benedetto, Enos Bernasconi, Patrick Schmid, Catia Marzolini, François R. Girardin, Thierry Buclin, Laurent A. Decosterd, Monia Guidi
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Pharmacology
Subjects:
rilpivirine
population pharmacokinetics
HIV
NONMEM
long-acting injectable
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1437400/full
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https://www.frontiersin.org/articles/10.3389/fphar.2024.1437400/full

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