Vitamin D status on remission of relapsing nephrotic syndrome among children at a South Asian tertiary hospital
Abstract Background Vitamin D has a profound role in calcium and phosphorous homeostasis as well as in bone health. On the other hand, steroid plays a significant role of treatment in children with nephrotic syndrome (NS). NS and steroid therapy plays a crucial role in biochemical derangements in ca...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2025-06-01
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| Series: | Egyptian Pediatric Association Gazette |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43054-025-00374-7 |
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| Summary: | Abstract Background Vitamin D has a profound role in calcium and phosphorous homeostasis as well as in bone health. On the other hand, steroid plays a significant role of treatment in children with nephrotic syndrome (NS). NS and steroid therapy plays a crucial role in biochemical derangements in calcium metabolism and vitamin D (25 (OH) D) so children are at risk of vitamin D deficiency. Objective To assess serum 25 (OH) D levels in children with relapsing NS and compare with different types of relapsing NS. Methods This cross sectional study was carried out from October 2023 to March 2024 at the pediatric nephrology department of a tertiary care hospital Dhaka, Bangladesh, a developing country of South Asia. Children aged between 2 and 15 years diagnosed cases of steroid sensitive NS (SSNS), who had history of one or more episodes of relapses with normal renal function and who were on alternate day steroid therapy had enrolled in this study. Patients were excluded if they had proteinuria, severe malnutrition, liver diseases, and malabsorption, or were on treatment with vitamin D and/or calcium and vitamin D supplementation at least in last 2 weeks. 25 (OH) D, and serum calcium, phosphate, parathormone (PTH) and alkaline phosphatase (ALP) were measured. Results A total of 33 children with SSNS mean age was 6.13 ± 3.50 years with mean duration of disease, and cumulative doses of steroids (mg/kg) were 3.26 ± 1.98 years and 636.40 ± 5.56 (mg/kg), respectively. Mean 25 (OH) D level was 13.47 ± 8.80 ng/ml, and 51.51% of study subject had insufficiency, 27.27% had deficiency, and 15.15% patients had severe deficiency. However, in multivariate regression, only serum calcium and phosphate significantly predict 25 (OH) D deficiency (p-value − 0.00 and p = 0.03 respectively and adjusted R 2 = 0.38). Conclusion In this study, majority of children had 25 (OH) D insufficiency, and deficiency was present in one-third of the patients. Serum calcium and inorganic phosphate significantly predict 25(OH) D deficiency. |
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| ISSN: | 2090-9942 |