Modulation of the endocannabinoid system by (S)-ketamine in an animal model of depression

Modulation of the endocannabinoid system by (S)-ketamine in an animal model of depression

Ketamine (KET) is recognized as rapid-acting antidepressant, but its mechanisms of action remain elusive. Considering the role of endocannabinoids (eCB) in stress and depression, we investigated if S-KET antidepressant effects involve the regulation of the eCB system using an established rat model o...

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Bibliographic Details
Main Authors: Nicole R. Silva, Shokouh Arjmand, Luana B. Domingos, Adriano M. Chaves-Filho, Melina Mottin, Caroline C. Real, Anna L. Waszkiewicz, Pedro H. Gobira, Alessio Nicola Ferraro, Anne M. Landau, Carolina H. Andrade, Heidi K. Müller, Gregers Wegener, Sâmia R.L. Joca
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Pharmacological Research
Subjects:
S-Ketamine
Flinders sensitive line
Endocannabinoids
Lipidome
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661824004900
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