Change in pericardial fat volume in postmenopausal women with papillary thyroid cancer undergoing thyrotropin suppressive therapy
Abstract Background Despite TSH suppressive therapy improve the prognosis for the patient with differentiated thyroid cancer (DTC), there is an increasing concern regarding the potentially harmful effects of lifelong TSH suppression. Therefore, we aimed to examine the changes in body composition und...
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BMC
2025-01-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | https://doi.org/10.1186/s12902-024-01800-4 |
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| author | Yunkyung Jeon Doohwa Kim Mijin Kim Bo Hyun Kim Kyoungjune Pak Jihyun Kim Keunyoung Kim |
| author_facet | Yunkyung Jeon Doohwa Kim Mijin Kim Bo Hyun Kim Kyoungjune Pak Jihyun Kim Keunyoung Kim |
| author_sort | Yunkyung Jeon |
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| description | Abstract Background Despite TSH suppressive therapy improve the prognosis for the patient with differentiated thyroid cancer (DTC), there is an increasing concern regarding the potentially harmful effects of lifelong TSH suppression. Therefore, we aimed to examine the changes in body composition under TSH suppression in postmenopausal women with DTC. Methods The body composition was assessed by the volumes as following; fat tissues of the epicardium and abdominal visceral and subcutaneous areas; bilateral psoas muscle or thigh muscle. Each volumetric measurements were performed using computed tomography (CT) scans using baseline and follow-up fluorine-18 fluorodeoxyglucose positron emission tomography/CT (18F-FDG PET/CT)s for 2-year follow up period in Pusan National University Hospital, South Korea. Results The 43 patients’ median age was 50.0 years, and median body mass index (BMI) was 23.53 (interquartile range[IQR]: 22.19- 24.92) at the initial 18F-FDG PET/CT. The median follow-up period was 19.24 months (IQR: 17.24–21.79). No significant change in weight or BMI were observed during follow-up. Volumes of fat and muscles was not changed significantly except epicardial fat volume. The epicardial fat volume significantly increased during the follow-up period. The epicardial fat volumes were correlated with visceral fat volume, respectively, however, the changing ratio was only correlated with TSH suppression on multiple regression analysis. Conclusion Both skeletal muscle and abdominal fat volumes did not change, whereas epicardial fat volume increased over less than 2 years of observation under TSH suppressive therapy. Further research is needed for the harmonization of benefits or losses with the optimal TSH concentration in postmenopausal women. |
| format | Article |
| id | doaj-art-581b9f47b299421db0df9dc220e0e242 |
| institution | Kabale University |
| issn | 1472-6823 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Endocrine Disorders |
| spelling | doaj-art-581b9f47b299421db0df9dc220e0e2422025-01-12T12:27:06ZengBMCBMC Endocrine Disorders1472-68232025-01-012511910.1186/s12902-024-01800-4Change in pericardial fat volume in postmenopausal women with papillary thyroid cancer undergoing thyrotropin suppressive therapyYunkyung Jeon0Doohwa Kim1Mijin Kim2Bo Hyun Kim3Kyoungjune Pak4Jihyun Kim5Keunyoung Kim6Division of Endocrinology, Department of Internal Medicine, Pusan National University HospitalDivision of Endocrinology, Department of Internal Medicine, Pusan National University HospitalDivision of Endocrinology, Department of Internal Medicine, Pusan National University HospitalDivision of Endocrinology, Department of Internal Medicine, Pusan National University HospitalDepartment of Nuclear Medicine and Biomedical Research Institute, Pusan National University HospitalDepartment of Nuclear Medicine and Biomedical Research Institute, Pusan National University HospitalDepartment of Nuclear Medicine and Biomedical Research Institute, Pusan National University HospitalAbstract Background Despite TSH suppressive therapy improve the prognosis for the patient with differentiated thyroid cancer (DTC), there is an increasing concern regarding the potentially harmful effects of lifelong TSH suppression. Therefore, we aimed to examine the changes in body composition under TSH suppression in postmenopausal women with DTC. Methods The body composition was assessed by the volumes as following; fat tissues of the epicardium and abdominal visceral and subcutaneous areas; bilateral psoas muscle or thigh muscle. Each volumetric measurements were performed using computed tomography (CT) scans using baseline and follow-up fluorine-18 fluorodeoxyglucose positron emission tomography/CT (18F-FDG PET/CT)s for 2-year follow up period in Pusan National University Hospital, South Korea. Results The 43 patients’ median age was 50.0 years, and median body mass index (BMI) was 23.53 (interquartile range[IQR]: 22.19- 24.92) at the initial 18F-FDG PET/CT. The median follow-up period was 19.24 months (IQR: 17.24–21.79). No significant change in weight or BMI were observed during follow-up. Volumes of fat and muscles was not changed significantly except epicardial fat volume. The epicardial fat volume significantly increased during the follow-up period. The epicardial fat volumes were correlated with visceral fat volume, respectively, however, the changing ratio was only correlated with TSH suppression on multiple regression analysis. Conclusion Both skeletal muscle and abdominal fat volumes did not change, whereas epicardial fat volume increased over less than 2 years of observation under TSH suppressive therapy. Further research is needed for the harmonization of benefits or losses with the optimal TSH concentration in postmenopausal women.https://doi.org/10.1186/s12902-024-01800-4Differentiated thyroid cancerTSH suppressive therapyEpicardial fatMenopauseBody compositionF-18 FDG PET/CT |
| spellingShingle | Yunkyung Jeon Doohwa Kim Mijin Kim Bo Hyun Kim Kyoungjune Pak Jihyun Kim Keunyoung Kim Change in pericardial fat volume in postmenopausal women with papillary thyroid cancer undergoing thyrotropin suppressive therapy BMC Endocrine Disorders Differentiated thyroid cancer TSH suppressive therapy Epicardial fat Menopause Body composition F-18 FDG PET/CT |
| title | Change in pericardial fat volume in postmenopausal women with papillary thyroid cancer undergoing thyrotropin suppressive therapy |
| title_full | Change in pericardial fat volume in postmenopausal women with papillary thyroid cancer undergoing thyrotropin suppressive therapy |
| title_fullStr | Change in pericardial fat volume in postmenopausal women with papillary thyroid cancer undergoing thyrotropin suppressive therapy |
| title_full_unstemmed | Change in pericardial fat volume in postmenopausal women with papillary thyroid cancer undergoing thyrotropin suppressive therapy |
| title_short | Change in pericardial fat volume in postmenopausal women with papillary thyroid cancer undergoing thyrotropin suppressive therapy |
| title_sort | change in pericardial fat volume in postmenopausal women with papillary thyroid cancer undergoing thyrotropin suppressive therapy |
| topic | Differentiated thyroid cancer TSH suppressive therapy Epicardial fat Menopause Body composition F-18 FDG PET/CT |
| url | https://doi.org/10.1186/s12902-024-01800-4 |
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